IL-7R-α binding compounds
IL-7Rα ligands and compounds comprising IL-7Rα ligands are disclosed. The IL-7Rα binding compounds include fusion proteins comprising the IL-7Rα ligands and can act as IL-7R agonists.
1. An IL-7Rα ligand, wherein,
the IL-7Rα ligand binds to the human IL-7Rα subunit with an IC 50 of less than 100 μM; and
the IL-7Rα ligand consists of an amino acid sequence selected from any one of SEQ ID NOS: 402, 407, 582, and 655.
2. The IL-7Rα ligand of claim 1 , wherein the IL-7Rα ligand consists of the amino acid sequence of SEQ ID NO: 402.
3. The IL-7Rα ligand of claim 1 , wherein the IL-7Rα ligand consists of the amino acid sequence of SEQ ID NO: 407.
4. The IL-7Rα ligand of claim 1 , wherein the IL-7Rα ligand consists of the amino acid sequence of SEQ ID NO: 582.
5. The IL-7Rα ligand of claim 1 , wherein the IL-7Rα ligand consists of the amino acid sequence of SEQ ID NO: 655.
6. A compound comprising at least one IL-7Rα ligand of claim 1 .
7. The compound of claim 6 , wherein the compound is selected from a peptide, a conjugate, and a fusion protein.
8. A pharmaceutical composition comprising the IL-7Rα ligand of claim 1 .
9. A pharmaceutical composition comprising the compound of claim 6 .