Microneedle array
An object of the present invention is to provide a microneedle array which is capable of suppressing aggregation of liposomes in a case where a water-soluble polymer is mixed with liposomes during production of the microneedle array and is capable of localizing a drug at a tip of a needle. According to the present invention, provided is a microneedle array including: a sheet; and a plurality of needles which are present on an upper surface of the sheet, in which each needle contains a water-soluble polymer, a drug, a liposome, and a salt, a zeta potential of the liposome is −10 mV or less, the zeta potential is a zeta potential of a liquid obtained by diluting the liposome to 0.1 mg/mL with 10 mmol/L of a phosphoric acid aqueous solution having a pH of 7, and a content of the salt in a portion of each needle which contains the liposome is 2.5 mmol/g or less.
1. A microneedle array comprising:
a sheet; and
a plurality of needles which are present on an upper surface of the sheet,
wherein each needle is formed from a solution which contains a water-soluble polymer, a drug, a liposome, and a salt, and the drug is localized at a tip of the needle,
a zeta potential of the liposome is −10 mV or less,
the zeta potential is a zeta potential of a liquid obtained by diluting the liposome to 0.1 mg/mL with 10 mmol/L of a phosphoric acid aqueous solution having a pH of 7,
a content of the salt in a portion of each needle which contains the liposome is 2.5 mmol/g or less,
the liposome contains an anionic compound,
the anionic compound is at least one selected from the group consisting of phosphatidylglycerol, phosphatidylserine, phosphatidic acid, a lipid containing a polyoxyethylene chain, and a saponin, and
the water-soluble polymer is at least one selected from the group consisting of polyethylene glycol, polyvinylpyrrolidone, dextran, dextrin, hydroxyethyl starch, and a cellulose derivative.
2. The microneedle array according to claim 1 ,
wherein the water-soluble polymer is electrically neutral.
3. The microneedle array according to claim 1 ,
wherein the water-soluble polymer is hydroxyethyl starch, and
the liposome contains phosphatidylcholine and distearoyl phosphatidylglycerol.
4. The microneedle array according to claim 1 ,
wherein the drug is a hormone or a vaccine.
5. The microneedle array according to claim 1 ,
wherein the salt is a salt containing at least one selected from the group consisting of a sodium ion, a potassium ion, an ammonium ion, a lithium ion, and a silver ion.
6. The microneedle array according to claim 1 , wherein the zeta potential of the liposome is from −10 mV to −100 mV.
7. The microneedle array according to claim 1 , wherein the content of the salt in a portion of each needle which contains the liposome is from 0.01 mmol/g to 2.5 mmol/g.
8. The microneedle array according to claim 1 , wherein the zeta potential of the liposome is of a value effective to suppress aggregation of liposomes.
9. The microneedle array according to claim 1 , wherein the zeta potential of the liposome is of a value effective to suppress aggregation of liposomes in a case where a water-soluble polymer is mixed with liposomes during production of the microneedle array.
10. The microneedle array according to claim 1 , wherein the zeta potential of the liposome results in suppressing aggregation of liposomes.
11. The microneedle array according to claim 1 , wherein the zeta potential of the liposome results in suppressing aggregation of liposomes in a case where a water-soluble polymer is mixed with liposomes during production of the microneedle array.
12. A microneedle array comprising:
a sheet; and
a plurality of needles which are present on an upper surface of the sheet,
wherein each needle is formed from a solution which contains a water-soluble polymer, a drug, a liposome, and a salt, and the drug is localized at a tip of the needle,
the zeta potential of the liposome is in a range from −10 mV to −100 mV and is of a value effective to suppress aggregation of liposomes,
the zeta potential is a zeta potential of a liquid obtained by diluting the liposome to 0.1 mg/mL with 10 mmol/L of a phosphoric acid aqueous solution having a pH of 7,
the content of the salt in a portion of each needle which contains the liposome is from 0.01 mmol/g to 2.5 mmol/g,
the liposome contains an anionic compound,
the anionic compound is at least one selected from the group consisting of phosphatidylglycerol, phosphatidylserine, phosphatidic acid, a lipid containing a polyoxyethylene chain, and a saponin, and
the water-soluble polymer is at least one selected from the group consisting of polyethylene glycol, polyvinylpyrrolidone, dextran, dextrin, hydroxyethyl starch, and a cellulose derivative.
13. The microneedle array according to claim 12 , wherein the water-soluble polymer is electrically neutral.
14. The microneedle array according to claim 12 , wherein the water-soluble polymer is hydroxyethyl starch, and the liposome contains phosphatidylcholine and distearoyl phosphatidylglycerol.
15. The microneedle array according to claim 12 , wherein the drug is a hormone or a vaccine.
16. The microneedle array according to claim 12 , wherein the zeta potential of the liposome results in suppressing aggregation of liposomes in a case where a water-soluble polymer is mixed with liposomes during production of the microneedle array.