Dentifrice composition comprising zinc oxide and zinc citrate
Described herein are oral care compositions comprising a combination of zinc oxide and zinc citrate, and methods of preparing and using the same.
1. An oral care composition having synergistic zinc antibacterial effects comprising zinc oxide and zinc citrate
wherein the weight ratio of zinc oxide: zinc citrate is 2:1, and wherein the amount of zinc oxide is 0.5 to 1.5% and the amount of zinc citrate is 0.25 to 0.75%, by weight of composition;
wherein the composition comprises sodium fluoride;
wherein the composition exhibits antibacterial effects measured as reduction in colony forming units after the composition is applied to incubated hydroxyapatite disks, which are incubated for 8 days, collected aseptically, and transferred to a half-strength, pre-reduced, thioglycollate medium; and
wherein the composition further comprises sodium lauryl sulfate.
2. The composition of claim 1 , wherein the amount of zinc oxide is 1% and the amount of zinc citrate is 0.5%.
3. The composition of claim 1 , further comprising an orally acceptable carrier.
4. The composition of claim 1 in the form of a dentifrice.
5. The composition of claim 1 in the form of a toothpaste or tooth gel.
6. The composition of claim 1 , wherein the composition comprises greater than 15%, by weight, free water.
7. A method of treating or preventing a disease or condition of the oral cavity comprising contacting an oral cavity surface of a patient in need thereof with the composition of claim 1 .
8. The method of claim 7 , wherein the disease or condition of the oral cavity is halitosis.
9. A method of reducing or inhibiting biofilm formation in an oral cavity comprising applying a composition according to claim 1 .