IP Library › Granted Patent US 11,278,861
Granted Patent B2
US 11,278,861 · App. 16/900,091 · Granted Mar 22, 2022

Plasmonic assisted systems and methods for interior energy-activation from an exterior source

Inventors: Frederic A. Bourke, Jr. (Aspen, CO); Tuan Vo-Dinh (Durham, NC)
Assignees: IMMUNOLIGHT, LLC; DUKE UNIVERSITY
B01J19/123A23L2/50A23L3/26A23L3/263A23L3/28A23L5/32A61K41/0057A61K41/0066A61L2/0011A61L2/0047A61L2/0076A61L2/082A61L2/088A61L2/10A61L2/16A61M1/3683A61N5/062A61N5/0624A61N5/10B01J19/082B01J19/085B01J19/12B01J19/125B01J19/127B01J19/128B01J23/50B01J23/52B01J31/0275B01J31/2295B01J35/004B01J35/0006B01J35/0013B01J37/0072B01J37/0221C02F1/30C02F1/305C02F1/307C02F1/32C02F1/725C08J3/24C08J3/28C08J7/18C09D201/00C09J5/00C09J201/00C12H1/06G02B5/008G21K5/00A23V2002/00A61L2202/21A61L2202/22A61N2005/0661A61N2005/0662A61N2005/1087A61N2005/1089A61N2005/1098B01J2219/0877B01J2219/0879B01J2219/0892B01J2219/1203B01J2231/005B01J2531/005B01J2531/008B82Y20/00B82Y30/00B82Y40/00C02F1/302C02F2305/10C08J2300/00C09J2301/416Y02W10/37Y10S977/774Y10S977/777Y10S977/896Y10S977/915Y10T156/10
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Quick Facts
Patent No.
US 11,278,861
App. No.
16/900,091
Filed
Jun 12, 2020
Granted
Mar 22, 2022
Kind
B2
Art Unit
1765
USPC
522/1
Abstract

A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.

Claims (45)

1. A sterilization system, comprising:

an initiation energy source configured to apply initiation energy to a medium to be sterilized; and

plasmonics agents disposed in a vicinity of the medium, said plasmonics agent is configured to enhance or modify an energy being transmitted in a vicinity of the plasmonics agent,

wherein the initiation energy interacts with the plasmonics agent to directly or indirectly sterilize the medium.

2. The system of claim 1 , further comprising encapsulated structures including the plasmonics agents.

3. The system of 2 , wherein the encapsulated structures comprise:

a fluidized bed;

re-entrant structures extending into a container holding said medium; or

interior walls of a container holding said medium.

4. The system of 2 , wherein the encapsulated structures comprise energy modulation agents encapsulated with a passivation layer.

5. The system of 2 , wherein the encapsulated structures include sealed tubes including the plasmonics agents.

6. The system of 2 , wherein the encapsulated structures include sealed tubes having the plasmonics agents disposed on an outside of the sealed tube.

7. The system of 1 , wherein the plasmonics agents comprise metal structures.

8. The system of claim 7 , wherein the metal structures comprises at least one of nanospheres, nanorods, nanocubes, nanopyramids, nanoshells, multi-layer nanoshells, and combinations thereof.

9. The system of claim 1 , wherein:

an energy modulation agent is disposed adjacent at least one metal nanoparticle serving as the plasmonics agent;

the energy modulation agent is coated at least partially with a metal serving as the plasmonics agent;

the energy modulation agent includes a magnetic substance; or

the energy modulation agent includes a chemical or biological receptor.

10. The system of claim 1 , wherein:

a metal nanoparticle serving as the plasmonics agent is at least partially covered with the energy modulation agent;

the metal nanoparticle includes a magnetic substance; or

the metal nanoparticle includes a chemical or biological receptor.

11. The system of claim 1 , wherein:

the plasmonics agent comprises a dielectric-metal nanocomposite; or

the plasmonics agent comprises a plurality of differently sized metal nanoparticles disposed in the vicinity of each other as a composite plasmonics agent.

12. The system of claim 1 , wherein the initiation energy is at a higher energy than that produced by an energy modulation agent or is at a lower energy than that produced by the energy modulation agent.

13. The system of claim 1 , further comprising an energy modulation agent including at least one of a sulfide, a telluride, a selenide and an oxide semiconductor.

14. The system of claim 13 , wherein the energy modulation agent comprises Y 2 O 3 ; ZnS; ZnSe; MgS; CaS; Mn, Er ZnSe; Mn, Er MgS; Mn, Er CaS; Mn, Er ZnS; Mn, Yb ZnSe; Mn, Yb MgS; Mn, Yb CaS; Mn, Yb ZnS:Tb 3+ , Er 3+ ; ZnS:Tb 3+ ; Y 2 O 3 :Tb 3+ ; Y 2 O 3 :Tb 3+ , Er3 + ; ZnS:Mn 2+ ; ZnS:Mn,Er 3+ .

15. The system of claim 1 , further comprising an activatable agent included in the medium and selected from psoralens, pyrene cholesteryloleate, acridine, porphyrin, fluorescein, rhodamine, 16-diazorcortisone, ethidium, transition metal complexes of bleomycin, transition metal complexes of deglycobleomycin organoplatinum complexes, alloxazines, vitamin Ks, vitamin L, vitamin metabolites, vitamin precursors, naphthoquinones, naphthalenes, naphthols and derivatives thereof having planar molecular conformations, porphorinporphyrins, dyes and phenothiazine derivatives, coumarins, quinolones, quinones, and anthroquinones.

16. The system of claim 15 , wherein the activatable agent comprises a psoralen, a coumarin, or a derivative thereof.

17. The system of claim 16 , wherein at least one of a cancer cell, a tumor cell, an autoimmune deficiency symptom virus, or a blood-borne germicide is treated by the psoralen, the coumarin, or the derivative thereof.

18. The system of claim 1 , further comprising a container which receives and transmits the initiation energy to fluid products to treat the fluid products.

19. The system of claim 1 , further comprising sealed tubes transmitting light from the initiation energy source into the medium to be sterilized.

20. The system of claim 19 , wherein the plasmonics agents are disposed on a side of the sealed tube in contact with the medium.

21. The system of claim 19 , wherein the initiation energy source comprises a UV light source.

22. The system of claim 19 , wherein the initiation energy source comprises a broad band light source.

23. The system of claim 1 , further comprising energy modulation agents included in a vicinity of the medium, wherein

the initiation energy source comprises a source producing at least one of x-rays, gamma rays, an electron beam, UV radiation, visible light, infrared radiation, microwaves, chemical energy, or radio waves, and

the energy modulation agents convert energy from the initiation energy source into a sterilization light.

24. The system of claim 1 , further comprising energy modulation agents included in a vicinity of the medium, wherein

the initiation energy source comprises a source producing at least one of x-rays, gamma rays, an electron beam, UV radiation, visible light, infrared radiation, microwaves, chemical energy, or radio waves; and

the energy modulation agents convert energy from the initiation energy source into a light which activates at least one photactivatable agent contained in the medium to be sterilized.

25. The system of claim 24 , wherein the at least one photoactivatable agent is selected from psoralens, pyrene cholesteryloleate, acridine, porphyrin, fluorescein, rhodamine, 16-diazorcortisone, ethidium, transition metal complexes of bleomycin, transition metal complexes of deglycobleomycin organoplatinum complexes, alloxazines, vitamin Ks, vitamin L, vitamin metabolites, vitamin precursors, naphthoquinones, naphthalenes, naphthols and derivatives thereof having planar molecular conformations, porphorinporphyrins, dyes and phenothiazine derivatives, coumarins, quinolones, quinones, and anthroquinones.

26. The system of claim 1 , further comprising a magnetic mechanism configured to provide to the medium or collect from the medium the plasmonics agents.

Continuity (10)
Continuation 16238443 · Jan 2, 2019
Continuation 15408003 · Jan 17, 2017
Continuation 14851196 · Sep 11, 2015
Continuation 14245644 · Apr 4, 2014
Continuation 13889925 · May 8, 2013
Continuation 13713931 · Dec 13, 2012
Continuation 12401478 · Mar 10, 2009
Provisional Application 61080140 · Jul 11, 2008
Provisional Application 61035559 · Mar 11, 2008
Related Publication 20200306717A1 · Oct 1, 2020
Cited By (2)
US 12,616,848 US 12,702,861