Heterodimer compositions and methods for the treatment of ocular disorders
Described herein are processable compositions comprising at least one moiety that is processable in its free form. Also described herein are compositions and methods for the treatment of ocular diseases or disorders including glaucoma, blepharitis, ocular inflammation, diabetic macular edema, posterior inflammation, anterior inflammation, macular degeneration (e.g., wet macular degeneration (AMD) or dry AMD), post-cataract surgery, and retinal vein occlusion. Said compositions and methods comprise steroids and prostaglandins which demonstrate anti-inflammatory activity, intraocular pressure (IOP) lowering, and/or other desirable activities. Injection of said compositions in the eye provides therapeutic benefit to patients suffering from ocular disorders.
1. A compound of a structure represented by Formula (VI-C):
or a pharmaceutically acceptable salt thereof,
wherein,
L is a linker; and
PG is a prostaglandin radical.
2. The compound of claim 1 , wherein PG is represented by a structure of Formula (IIA):
wherein:
is a single bond or a double bond;
R 1 and R 3 are OH;
R 2 is hydrogen;
R 4 is alkyl substituted with oxo, —C(═O)OC 1 -C 3 alkyl, —COOH, —CONH 2 , or —CONHC 1 -C 3 alkyl;
R 5 is —O-aryl or arylalkyl; and
R 6 and R 6′ are each independently hydrogen, halogen, or OH.
3. The compound of claim 1 , wherein L is a bond.
4. The compound of claim 1 , wherein L comprises one or more linker group, each linker group being independently selected from the group consisting of alkyl, cycloalkyl, heteroalkyl, and alkoxy, wherein the alkyl, cycloalkyl, heteroalkyl, or alkoxy is optionally substituted.
5. The compound of claim 1 , of the structure:
6. The compound of claim 1 , of the structure:
7. The compound of claim 1 , of the structure:
8. The compound of claim 1 , of the structure:
9. The compound of claim 1 , of the structure:
10. The compound of claim 1 , having of the structure:
11. A pharmaceutical implant comprising at least 50 wt. % of the compound of claim 1 .