Vaccine composition comprising cyclic peptides, antibodies to the cyclic peptides or an anticancer composition comprising the same
The present invention relates to a vaccine composition comprising cyclic peptides of the present invention, antibodies to cyclic peptides, or an anticancer composition comprising them, and the vaccine composition of the present invention exhibit an inhibitory activity for metastasis of cancer. In addition, the antibodies of the present invention bind to the tumor-specific antigen TM4SF5 with high affinity, and significantly inhibit the growth, metastasis and invasion of cancer cells expressing the tumor-specific antigen TM4SF5, and thus can be used for diagnosis, prevention or treatment of various cancers expressing TM4SF5.
1. The antibody against peptides, said peptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOS: 1 and 2 or peptides comprising an amino acid sequence selected from the group consisting of cyclic peptides linked by a disulfide bond between the 3rd cysteine amino acid and the 26th cysteine amino acid in sequences of SEQ ID NO: 1 or SEQ ID NO: 2,
wherein said antibody comprises a heavy chain variable region having a heavy chain complementarity determining region (CDR) amino acid sequence of CDRH1 consisting of the sequence of SEQ ID NO: 3 or SEQ ID NO: 4 of the sequence listing, CDRH2 consisting of the sequence of SEQ ID NO: 5 or SEQ ID NO: 6 of the sequence listing, and CDRH3 consisting of the sequence of SEQ ID NO: 7 or SEQ ID NO: 8 of the sequence listing; and
a light chain variable region having a light chain CDR amino acid sequence of CDRL1 consisting of the sequence of SEQ ID NO: 9 or SEQ ID NO: 10 of the sequence listing, CDRL2 consisting of SEQ ID NO: 11 or SEQ ID NO: 12 of the sequence listing and CDRL3 consisting of SEQ ID NO: 13 or SEQ ID NO: 14.
2. The antibody according to claim 1 , characterized in that the heavy chain variable region has the amino acid sequence of SEQ ID NO:15 or SEQ ID NO:16.
3. The antibody according to claim 1 , characterized in that the light chain variable region has the amino acid sequence of SEQ ID NO:17 or SEQ ID NO:18.