2-hetarylpyrimidine-4-carboxamides as aryl hydrocarbon receptor antagonists

1. A compound of formula (I):

wherein

X is CH;

Y is CR 3 ;

Z is CH;

R 1 is C 2 -C 6 -hydroxyalkyl, wherein said C 2 -C 6 -hydroxyalkyl groups are optionally substituted once with R 7 and optionally one to three times with fluoro, or C 4 -C 6 -cycloalkyl substituted once with hydroxy and optionally one to two times with fluoro, or (C 4 -C 6 -cycloalkyl substituted once with hydroxy)-methyl, or 4-hydroxyoxolan-3-yl, 4-hydroxythiolan-3-yl or 4-hydroxy-1,1-dioxo-1lambda 6 -thiolan-3-yl;

R 2 is chloro, difluoromethyl, trifluoromethyl, or trifluoromethoxy;

R 3 is hydrogen;

R 4 is a group selected from the group consisting of

wherein * indicates the point of attachment of said group with the rest of the molecule;

R 6a is hydrogen or methoxy;

R 6b is hydrogen, methyl, methoxy, or cyano;

R 6c is hydrogen, chloro, methyl, or cyano;

R 6d is hydrogen or methyl;

R 6e is hydrogen, methyl, isobutyl, or cyclopropyl;

R 6f is hydrogen or methyl;

R 6ff is hydrogen or methyl;

R 6g is hydrogen or methyl;

R 6h is hydrogen or methyl;

R 6i is hydrogen or methyl;

R 6k is hydrogen, chloro, or cyano;

R 6m is hydrogen or methyl;

R 7 is cyano, C 3 -C 4 -cycloalkyl, or pyridinyl; or

a polymorph, an enantiomer, a diastereomer, a racemate, a tautomer, an N-oxide, a hydrate, or a solvate, a physiologically acceptable salt, or a solvate of a physiologically acceptable salt thereof.

2. The compound according to claim 1 which is selected from the group consisting of

N-[(2S)-1-hydroxypropan-2-yl]-2-(pyridin-3-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2R)-1-hydroxypropan-2-yl]-2-(pyridin-3-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-(2-hydroxy-2-methylpropyl)-2-(pyridin-3-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2-(pyridin-3-yl)-N-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-(2-hydroxy-2-methylpropyl)-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-(2-hydroxy-2-methylpropyl)-2-(pyridin-3-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidine-4-carboxamide;

N-(2-hydroxy-2-methylpropyl)-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(pyridin-3-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2-(pyridin-3-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(1-methyl-1H-pyrazol-4-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-[(2R)-1-hydroxypropan-2-yl]-2-(1-methyl-1H-pyrazol-4-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2-(1-methyl-1H-pyrazol-4-yl)pyrimidine-4-carboxamide;

N-(2-hydroxy-2-methylpropyl)-2-(6-methoxypyridin-3-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-(2-hydroxy-2-methylpropyl)-2-(thiophen-2-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-(2-hydroxy-2-methylpropyl)-2-(4-methylthiophen-3-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-(2-hydroxy-2-methylpropyl)-2-(thiophen-3-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2-(5-chlorothiophen-2-yl)-N-(2-hydroxy-2-methylpropyl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-(2-hydroxy-2-methylpropyl)-2-(3-methylthiophen-2-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-(2-hydroxy-2-methylpropyl)-2-(1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-(2-hydroxy-2-methylpropyl)-2′-methyl-6-[4-(trifluoromethoxy)phenyl][2,5′-bipyrimidine]-4-carboxamide;

N-(2-hydroxy-2-methylpropyl)-2-(1,2-oxazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2′-cyano-N-(2-hydroxy-2-methylpropyl)-6-[4-(trifluoromethoxy)phenyl][2,5′-bipyrimidine]-4-carboxamide;

N-(2-hydroxy-2-methylpropyl)-2-(3-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2-(1,3-dimethyl-1H-pyrazol-4-yl)-N-(2-hydroxy-2-methylpropyl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2-(1-cyclopropyl-1H-pyrazol-4-yl)-N-(2-hydroxy-2-methylpropyl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2-(6-methoxypyridin-3-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2-(5-cyanothiophen-2-yl)-N-[(2S)-1-hydroxypropan-2-yl]-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2-(4-methylthiophen-3-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2-(thiophen-2-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2-(thiophen-3-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2-(5-chlorothiophen-2-yl)-N-[(2S)-1-hydroxypropan-2-yl]-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2-(3-methylthiophen-2-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2-(1-methyl-1H-pyrazol-5-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[(2S)-1-hydroxypropan-2-yl]-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2-[1-(2-methylpropyl)-1H-pyrazol-4-yl]-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2-(1H-pyrazol-3-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2-(6-cyanopyridin-3-yl)-N-[(2S)-1-hydroxypropan-2-yl]-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2-(6-methylpyridin-3-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2-(4-methoxypyridin-3-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2-(1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2′-methyl-6-[4-(trifluoromethoxy)phenyl][2,5′-bipyrimidine]-4-carboxamide;

2-(1,3-dimethyl-1H-pyrazol-4-yl)-N-[(2S)-1-hydroxypropan-2-yl]-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2-(1-cyclopropyl-1H-pyrazol-4-yl)-N-[(2S)-1-hydroxypropan-2-yl]-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2-(4-methyl-1H-pyrazol-5-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2-(6-methoxypyridin-3-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-2-(5-cyanothiophen-2-yl)-N-(2-hydroxy-2-methylpropyl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2-(4-methylthiophen-3-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2-(thiophen-2-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(thiophen-2-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2-(thiophen-3-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-2-(5-chlorothiophen-2-yl)-N-(2-hydroxy-2-methylpropyl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2-(3-methylthiophen-2-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2-(1-methyl-1H-pyrazol-5-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)[2,5′-bipyrimidine]-4-carboxamide;

6-(4-chlorophenyl)-2-(3,5-dimethyl-1,2-oxazol-4-yl)-N-(2-hydroxy-2-methylpropyl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2-[1-(2-methylpropyl)-1H-pyrazol-4-yl]pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2-(1H-pyrazol-3-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-2-(6-cyanopyridin-3-yl)-N-(2-hydroxy-2-methylpropyl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2-(6-methylpyridin-3-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2-(4-methoxypyridin-3-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2-(1H-pyrazol-4-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2′-methyl[2,5′-bipyrimidine]-4-carboxamide;

6-(4-chlorophenyl)-2′-cyano-N-(2-hydroxy-2-methylpropyl)[2,5′-bipyrimidine]-4-carboxamide;

6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)-2-(3-methyl-1H-pyrazol-4-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-N-(2-hydroxy-2-methylpropyl)pyrimidine-4-carboxamide;

2′-chloro-6-(4-chlorophenyl)-N-(2-hydroxy-2-methylpropyl)[2,5′-bipyrimidine]-4-carboxamide;

6-(4-chlorophenyl)-2-(1-cyclopropyl-1H-pyrazol-4-yl)-N-(2-hydroxy-2-methylpropyl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(6-methoxypyridin-3-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-2-(5-cyanothiophen-2-yl)-N-[(2S)-1-hydroxypropan-2-yl]pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(4-methylthiophen-3-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-2-(5-chlorothiophen-2-yl)-N-[(2S)-1-hydroxypropan-2-yl]pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(3-methylthiophen-2-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(1-methyl-1H-pyrazol-5-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl][2,5′-bipyrimidine]-4-carboxamide;

6-(4-chlorophenyl)-2-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[(2S)-1-hydroxypropan-2-yl]pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-[1-(2-methylpropyl)-1H-pyrazol-4-yl]pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-2-(6-cyanopyridin-3-yl)-N-[(2S)-1-hydroxypropan-2-yl]pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(6-methylpyridin-3-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(4-methoxypyridin-3-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(1H-pyrazol-4-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(3-methyl-1H-pyrazol-4-yl)pyrimidine-4-carboxamide;

6-(4-chlorophenyl)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-N-[(2S)-1-hydroxypropan-2-yl]pyrimidine-4-carboxamide;

2′-chloro-6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl][2,5′-bipyrimidine]-4-carboxamide;

6-(4-chlorophenyl)-2-(1-cyclopropyl-1H-pyrazol-4-yl)-N-[(2S)-1-hydroxypropan-2-yl]pyrimidine-4-carboxamide;

N-[(1R,2R)-2-hydroxycyclobutyl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(1S,2S)-2-hydroxycyclopentyl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2-(1-methyl-1H-pyrazol-4-yl)-N-[1,1,1-trifluoro-3-hydroxy-2-(hydroxymethyl)propan-2-yl]-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(1S,2R)-2-hydroxycyclopentyl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(1S,2S)-2-hydroxycyclohexyl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[1-hydroxy-3-(pyridin-3-yl)propan-2-yl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-(1-cyclobutyl-2-hydroxyethyl)-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2R)-1-fluoro-3-hydroxypropan-2-yl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(1R,2R)-2-hydroxycyclopentyl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(1-hydroxycyclobutyl)methyl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(3R,4S)-4-hydroxy-1,1-dioxo-1 lambda 6 -thiolan-3-yl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(1S)-1-cyclopropyl-2-hydroxyethyl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(3R,4R)-4-hydroxy-1,1-dioxo-1 lambda 6 -thiolan-3-yl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(1S)-1-cyano-2-hydroxyethyl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-3-hydroxy-3-methylbutan-2-yl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(3S,4S)-4-hydroxyoxolan-3-yl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-(3,4-dihydroxybutan-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(3R,4R)-4-hydroxyoxolan-3-yl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-(3,3-difluoro-2-hydroxycyclohexyl)-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(1S,2R)-2-hydroxycyclobutyl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(1-hydroxycyclohexyl)methyl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(1S,2R)-2-hydroxycyclohexyl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2-(1-methyl-1H-pyrazol-4-yl)-N-[(2R)-1,1,1-trifluoro-3-hydroxy-3-methylbutan-2-yl]-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(3S,4R)-4-hydroxythiolan-3-yl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2-(1-methyl-1H-pyrazol-4-yl)-N-[(2R)-1,1,1-trifluoro-3-hydroxypropan-2-yl]-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(1S,2R)-2-hydroxycyclohexyl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2-(1-methyl-1H-pyrazol-4-yl)-N-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

2-(1-methyl-1H-pyrazol-4-yl)-N-(1,1,1-trifluoro-3-hydroxybutan-2-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxypropan-2-yl]-2-(pyridin-3-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidine-4-carboxamide;

N-[(2S)-1-hydroxy-3-methylbutan-2-yl]-2-(1-methyl-1H-pyrazol-4-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

N-[(3S,4R)-4-hydroxyoxolan-3-yl]-2-(pyridin-3-yl)-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide;

6-[4-(difluoromethyl)phenyl]-N-[(2S)-3-hydroxy-3-methylbutan-2-yl]-2-(pyridin-3-yl)pyrimidine-4-carboxamide; and

6-[4-(difluoromethyl)phenyl]-N-(2-hydroxy-2-methylpropyl)-2-(pyridin-3-yl)pyrimidine-4-carboxamide; or

a polymorph, an enantiomer, a diastereomer, a racemate, a tautomer, an N-oxide, a hydrate, or a solvate, a physiologically acceptable salt, or a solvate of a physiologically acceptable salt thereof.

3. A method of preparing a compound of formula (I) according to claim 1 , said method comprising the step of reacting an intermediate compound of formula (VII):

or a salt thereof, wherein X, Y, Z, R 2 and R 4 are as defined for the compound of formula (I) according to claim 1 ,

with a compound of formula (VIII):

H 2 N—R 1    (VIII),

in which R 1 is as defined for the compound of formula (I) according to claim 1 , thereby giving a compound of formula (I):

or a salt thereof, wherein X, Y, Z, R 1 , R 2 and R 4 are as defined for the compound of formula (I) according to claim 1 .

4. A pharmaceutical composition comprising a compound of formula (I) according to claim 1 , or a polymorph, an enantiomer, a diastereomer, a racemate, a tautomer, an N-oxide, a hydrate, or a solvate, a physiologically acceptable salt, or a solvate of a physiologically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.

5. A pharmaceutical combination comprising:

one or more compounds of formula (I) according to claim 1 , or a polymorph, an enantiomer, a diastereomer, a racemate, a tautomer, an N-oxide, a hydrate, or a solvate, a physiologically acceptable salt, or a solvate of a physiologically acceptable salt thereof, and

one or more pharmaceutically active anti cancer compounds or

one or more pharmaceutically active immune checkpoint inhibitors.

6. The compound of claim 1 , or a salt thereof.

7. The compound of claim 2 , or a physiologically acceptable salt thereof.

8. A compound of formula (VII):

or a salt thereof, wherein

X is CH;

Y is CR 3 ;

Z is CH;

R 2 is chloro, difluoromethyl, trifluoromethyl, or trifluoromethoxy;

R 3 is hydrogen;

R 4 is a group selected from the group consisting of

wherein * indicates the point of attachment of said group with the rest of the molecule;

R 6a is hydrogen or methoxy;

R 6b is hydrogen, methyl, methoxy, or cyano;

R 6c is hydrogen, chloro, methyl, or cyano;

R 6d is hydrogen or methyl;

R 6e is hydrogen, methyl, isobutyl, or cyclopropyl;

R 6f is hydrogen or methyl;

R 6ff is hydrogen or methyl;

R 6g is hydrogen or methyl;

R 6h is hydrogen or methyl;

R 6i is hydrogen or methyl;

R 6k is hydrogen, chloro, or cyano; and

R 6m is hydrogen or methyl.

9. A method for treatment of cancer, comprising administering a therapeutically effective amount of a compound of formula (I) according to claim 1 , or a polymorph, an enantiomer, a diastereomer, a racemate, a tautomer, an N-oxide, a hydrate, or a solvate, a physiologically acceptable salt, or a solvate of a physiologically acceptable salt thereof, to a subject in need thereof.

10. The method according to claim 9 , wherein the disease is a liquid tumour or a solid tumour.

11. The method according to claim 10 , wherein the cancer is a solid tumour.