Oxygenator antithrombotic coating and method of manufacture
Hollow fiber membranes in an oxygenator for an extracorporeal blood circulator are coated with an antithrombotic polymeric material. The porous hollow fiber membranes for gas exchange have outer surfaces, inner surfaces forming lumens, opening portions through which the outer surfaces communicate with the inner surfaces in a housing. A blood flow path is outside of the hollow fiber membrane bundle in the housing, between a blood inlet port and a blood outlet port. The coating is obtained by filling the blood flow path with a colloidal solution containing an antithrombotic polymeric compound, and moving the colloid solution between the blood inlet port and the blood outlet port for a time that coats a predetermined amount of antithrombotic polymeric compound on the outer surfaces of the hollow fiber membranes. Other surfaces within the oxygenator contacting the blood flow likewise receive the coating.
1. A method for manufacturing an oxygenator having a housing retaining a hollow fiber membrane bundle, wherein the hollow fiber membrane bundle comprises a plurality of porous hollow fiber membranes for gas exchange which have outer surfaces, inner surfaces forming lumens, and opening portions through which the outer surfaces communicate with the inner surfaces, wherein the oxygenator defines a blood flow path which is outside of the hollow fiber membranes in the housing between a blood inlet port and a blood outlet port, the method comprising:
filling the blood flow path with a colloidal solution containing an antithrombotic polymeric compound; and
moving the colloidal solution along the blood flow path between the blood inlet port and the blood outlet port for a time that coats a predetermined amount of antithrombotic polymeric compound on the outer surfaces of the hollow fiber membranes;
wherein the lumens of the hollow fiber membranes are used as a gas flow path, and carbon dioxide gas is passed through the gas flow path while moving the colloidal solution between the blood inlet port and the blood outlet port.
2. The method for manufacturing an oxygenator according to claim 1 , wherein the colloidal solution is moved alternately back and forth between the blood inlet port and the blood outlet port.
3. The method for manufacturing an oxygenator according to claim 1 , wherein the colloidal solution is circulated by a pump coupled to the blood inlet port and the blood outlet port.
4. The method for manufacturing an oxygenator according to claim 1 , wherein a flow rate of the carbon dioxide gas is 0.5 L/min·m 2 or more and 20 L/min·m 2 or less with respect to a membrane area (m 2 ) of a hollow fiber membrane.
5. The method for manufacturing an oxygenator according to claim 1 , wherein the colloidal solution contains 0.01% by mass or more of an antithrombotic polymeric compound.
6. The method for manufacturing an oxygenator according to claim 1 , wherein the antithrombotic polymeric compound has a structural unit derived from alkoxyalkyl(meth)acrylate represented by the following Formula (I):
wherein R 3 represents a hydrogen atom or a methyl group, R 1 represents an alkylene group having 1 to 4 carbon atoms, and R 2 represents an alkyl group having 1 to 4 carbon atoms.
7. The method for manufacturing an oxygenator according to claim 1 , wherein a weight average molecular weight of the antithrombotic polymeric compound is more than 200,000 and less than 800,000.