IP Library › Granted Patent US 11,305,133
Granted Patent B2
US 11,305,133 · App. 15/937,549 · Granted Apr 19, 2022

Efficient acoustic energy transfer through skull via excitation of Lamb waves

Inventors: Butrus T. Khuri-Yakub (Palo Alto, CA); Kamyar Firouzi (Palo Alto, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University
A61N7/02A61N7/00A61B8/0808A61B8/4483A61B2018/00446A61N2007/0021A61N2007/0026A61N2007/0056A61N2007/0078A61N2007/0082A61N2007/0095G01N2800/52
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Quick Facts
Patent No.
US 11,305,133
App. No.
15/937,549
Granted
Apr 19, 2022
Kind
B2
Abstract

We provide a novel technique for coupling focused ultrasound into the brain. The ultrasound beam can be used for therapy or neuro-modulation. We excite a selected Lamb wave mode in the skull that mode converts into longitudinal waves in the brain. The benefits of our approach is in improved efficiency, reduction in heating of the skull, and the ability to address regions in the brain that are close or far from the skull.

Claims (10)

1. Apparatus for providing acoustic energy to a brain of a patient, the apparatus comprising:

an acoustic transducer configured to excite a selected Lamb wave mode in a skull of the patient via phase matching to the selected Lamb wave mode;

wherein the selected Lamb wave mode excites a longitudinal acoustic wave in the brain;

wherein the acoustic transducer comprises a heating element configured to deliver thermal energy to the skull of the patient, and wherein thermal expansion of the skull of the patient excites the selected Lamb wave mode.

2. The apparatus of claim 1 , wherein the acoustic transducer is configured as a ring to provide focusing of the longitudinal acoustic wave in the brain.

3. The apparatus of claim 1 , wherein the acoustic transducer comprises an electro-mechanical wedge transducer.

4. The apparatus of claim 3 , wherein a wedge angle of the electro-mechanical wedge transducer provides the phase matching to the selected Lamb wave mode.

5. The apparatus of claim 1 , wherein the acoustic transducer comprises an electro-mechanical interdigitated transducer.

6. The apparatus of claim 5 , wherein a periodicity of the electro-mechanical interdigitated transducer provides the phase matching to the selected Lamb wave mode.

7. The apparatus of claim 1 , wherein a pattern of thermal energy provided to the skull of the patient provides the phase matching to the selected Lamb wave mode.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 30, 2018
From: KHURI-YAKUB, BUTRUS T.; FIROUZI, KAMYAR
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 045400/0196 →
Continuity (2)
Provisional Application 62479819 · Mar 31, 2017
Related Publication 20180280735A1 · Oct 4, 2018
Cited By (2)
US 12,623,094 US 12,741,161