Pyridinones and isoquinolinones as inhibitors of the bromodomain BRD9
The present invention encompasses compounds of general formula (I) wherein the groups R 1 to R 9 , X 1 and X 2 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, e.g. cancer, pharmaceutical preparations containing such compounds and their uses as a medicament.
1. Compound
or its salts.
2. A pharmaceutical preparation containing as active substance the compound of claim 1 or a pharmaceutically acceptable salt thereof—optionally in combination with conventional excipients and/or carriers.
3. Compound
or its salts.
4. Compound
or its salts.
5. A pharmaceutical preparation containing as active substance the compound of claim 3 or a pharmaceutically acceptable salt thereof—optionally in combination with conventional excipients and/or carriers.
6. A pharmaceutical preparation containing as active substance the compound of claim 4 or a pharmaceutically acceptable salt thereof—optionally in combination with conventional excipients and/or carriers.