Compounds and methods for treating cancer
This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.
1. A compound according to Formula (II):
or a pharmaceutically acceptable salt thereof,
wherein
R 1 is halo;
X is —(C═O)NR 4 —;
Y is
and
R 2 , R 3 , and R 4 are each independently H or an unsubstituted C 1-6 alkyl.
2. The compound of claim 1 , wherein the compound according to Formula (II) has the structure of Formula (IIa):
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 , wherein R 1 is Cl.
4. The compound of claim 1 , wherein R 4 is H.
5. The compound of claim 1 , wherein R 2 is H and R 3 is CH 3 .
6. The compound of claim 1 , wherein the compound according to Formula (II) is
or a pharmaceutically acceptable salt thereof.
7. A pharmaceutical composition comprising a compound, or a pharmaceutically acceptable salt thereof, according to claim 1 , and a pharmaceutically acceptable carrier.