Ophthalmic composition
The first aspect of the present invention relates to an ophthalmic composition comprising (A) one or more kinds selected from the group consisting of terpenoid, a tocopherol, and a benzyl ammonium compound and a salt thereof, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin. The second aspect of the present invention relates to an ophthalmic composition comprising (A2) a surface active component and (B2) a buffer, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin.
1. An ophthalmic composition comprising terpenoid and a salt thereof, wherein
the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin comprising a cyclic olefin copolymer and polyethylene, wherein:
the cyclic olefin copolymer is a copolymer of norbornene and ethylene,
the polyethylene comprises low-density polyethylene and/or linear low-density polyethylene, and
the content of polyethylene is from 10 to 50% by weight based on a total amount of the resin forming the container.
2. The ophthalmic composition according to claim 1 , wherein the resin forming the container further contains polyethylene.
3. The ophthalmic composition according to claim 1 , further comprising (B) a buffer.
4. The ophthalmic composition according to claim 1 , wherein a content of water is 80 w/v % or more and less than 100 w/v % based on the total amount of the ophthalmic composition.
5. The ophthalmic composition according to claim 1 , wherein a maximum value of light transmittance in a visible light region of wavelengths from 400 to 700 nm of the container formed from the resin containing the cyclic olefin polymer and/or the cyclic olefin copolymer is 50% or more.
6. The ophthalmic composition according to claim 1 , exhibiting suppressed wetting to a resin containing a cyclic olefin.
7. The ophthalmic composition according to claim 1 , wherein the terpenoid is menthol.
8. The ophthalmic composition according to claim 1 , wherein the total content of the terpenoid is from 0.00005 to 1 w/v % based on the total amount of the ophthalmic composition.
9. The ophthalmic composition according to claim 3 , wherein (B) the buffer is selected from the group consisting of boric acid buffers, phosphoric acid buffers, carbonic acid buffers, citric acid buffers, acetic acid buffers, Tris buffers, epsilon aminocaproic acid buffers, and AMPD (2-amino-2-methyl-1,3-propanediol) buffers.
10. The ophthalmic composition according to claim 1 , wherein the container is a container with a composition containment part and a bung hole integrally formed.