IP Library Granted Patent US 11,333,626
Granted Patent B2
US 11,333,626 · App. 16/070,602 · Granted May 17, 2022

Biological sample analysis chip, biological sample analyzer and biological sample analysis method

Inventors: Mayu Aoki (Tokyo, JP); Kenichi Takeda (Tokyo, JP); Kunio Harada (Tokyo, JP)
Assignee: HITACHI, LTD.
G01N27/44791B01L3/502715G01N27/4145B01L2200/027B01L2300/0636B01L2300/0645B01L2400/0421G01N27/447G01N33/54373
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Quick Facts
Patent No.
US 11,333,626
App. No.
16/070,602
Granted
May 17, 2022
Kind
B2
Abstract

A biological sample analysis chip including a first substrate, a membrane disposed on the first substrate, a first liquid tank which is provided with a first electrode, a plurality of second liquid tanks each of which is provided with at least one flow path and a second electrode; and a second substrate disposed below the first substrate, in which the plurality of second liquid tanks are substantially insulated from each other, the membrane disposed on the first substrate is disposed between the first liquid tank and the plurality of second liquid tanks so as to form a portion of the first liquid tank and a portion of the plurality of second liquid tanks, and the second substrate is provided with the at least one flow path and the second electrode so as to form a portion of the plurality of second liquid tanks.

Claims (27)

1. A biological sample analysis chip comprising:

a first substrate;

a membrane disposed on the first substrate;

a first liquid tank which is provided with a first electrode;

a plurality of second liquid tanks each of which is provided with a second electrode;

a second substrate disposed below the first substrate; and

at least one flow path disposed entirely within the second substrate,

wherein the plurality of second liquid tanks are substantially insulated from each other,

wherein the membrane disposed on the first substrate is disposed between the first liquid tank and the plurality of second liquid tanks so as to form a portion of the first liquid tank and a portion of the plurality of second liquid tanks,

wherein the second substrate is provided with a plurality of wirings connected to ach of the second electrode and a plurality of external connection terminals connected to the plurality of wirings,

wherein a first surface of the second substrate facing the membrane forms a portion of the plurality of second liquid tanks,

wherein the at least one flow path disposed entirely within the second substrate extends linearly in a direction intersecting the first surface from the first surface, as an upper boundary, to a second surface of the second substrate opposite to the first surface, as a lower boundary,

wherein the plurality of external connection terminals are arranged in an outer periphery of the second surface of the second substrate, and

wherein the second electrode is disposed above the at least one flow path and is disposed on the first surface of the second substrate.

2. The biological sample analysis chip according to claim 1 , wherein

the membrane is provided with a plurality of pores respectively corresponding to each of the plurality of second liquid tanks.

3. The biological sample analysis chip according to claim 1 , wherein

the at least one flow path is formed of a through hole penetrating the second substrate.

4. The biological sample analysis chip according to claim 1 , wherein

the plurality of wirings include a metal via disposed inside the second substrate.

5. The biological sample analysis chip according to claim 1 , wherein

the second substrate is formed of a printed board having insulating properties.

6. The biological sample analysis chip according to claim 1 , wherein

the first substrate is disposed directly on the second substrate.

7. The biological sample analysis chip according to claim 1 , further comprising:

a support material disposed on the first substrate, wherein

the support material constitutes a portion of the first liquid tank.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 17, 2018
From: AOKI, MAYU; TAKEDA, KENICHI; HARADA, KUNIO
To: HITACHI, LTD.
Reel/Frame 046370/0691 →
Continuity (1)
Related Publication 20190022647A1 · Jan 24, 2019