C5 ketone compositions, and related methods, for therapeutic and performance supplementation
The present disclosure pertains to compositions and methods for the treatment and/or prevention of one or more of obesity, diabetes, metabolic syndrome, Alzheimer's disease, Chronic Fatigue Syndrome (CFS), aging, fibromyalgia, dyslipidemia, hypercholesterolemia, dyslipidemia, Parkinson's disease, migraines, Traumatic Brain Injury (TBI), Attention Deficit Disorder (ADD)/Attention Deficit Hyperactivity Disorder (ADHD), Cancer, Cardiovascular Disease (CVD)/Coronary Artery Disease (CAD), Chronic Pain, neuralgia, depression, amyotrophic lateral sclerosis (ALS), and epilepsy, Insufficient Cellular Energy (ICE) and mitochondrial dysfunction. The present disclosure also pertains to methods for increasing mental and/or physical performance levels and/or decreasing exertion during exercise in a subject by the administration of C5 ketones.
1. A method for aiding in at least one of weight loss or fat loss in an individual, the method comprising:
administering a composition to the individual, wherein the composition comprises 1 to 50 g of β-hydroxypentanoate or a salt thereof, and
wherein administration of the composition aids in at least one of weight loss and/or fat loss in the subject individual.
2. The method of claim 1 wherein the composition further comprises β-ketopentanoate or salt thereof.
3. The method of claim 1 wherein the β-hydroxypentanoate or salt thereof in the composition comprises about 1 to about 20 of β-hydroxypentanoate or salt thereof.
4. The method of claim 1 wherein the composition further comprises at least one other carbon length ketone that is not a C5-ketone.
5. The method of claim 1 wherein the composition further comprises is a C4-ketone.
6. The method of claim 1 wherein administration of the composition decreases blood glucose levels in the individual.
7. The method of claim 1 wherein the composition is formulated as a controlled release formulation or a sustained release formulation.
8. A method for increasing blood ketone levels in an individual, the method comprising:
orally administering a composition comprising about 1 g to about 50 g of at least one of:
β-hydroxypentanoate,
β-hydroxypentanoate salt,
β-ketopentanoate,
or β-ketopentanoate salt;
wherein the composition is administered orally to increase blood ketone levels in the subject.
9. A method for aiding in at least one of weight loss or fat loss in an individual, the method comprising:
orally administering a composition comprising about 1 g to about 50 g of β-ketopentanoate or a salt thereof;
wherein oral administration of the composition aids in at least one of weight loss or fat loss.
10. A composition for at least one of aiding in weight loss, aiding in fat loss, or increasing blood ketone levels in an individual, the composition consisting essentially of:
about 1 g to about 20 g of a C5-ketone or salt thereof, wherein the C5 ketone or salt thereof comprises at least one of β-hydroxypentanoate or β-ketopentanoate, and
optionally, at least one of:
one or more pharmaceutical carriers,
one or more pharmaceutical excipients,
one or more emulsifying agents,
one or more wetting agents,
one or more suspending agents,
one or more diluting agents,
one or more buffering agents,
or one or more release rate impacting agents;
wherein oral administration of the composition aids in at least one of weight loss, aids in fat loss, or increases blood ketone levels in the individual.
11. The method of claim 10 wherein the β-hydroxypentanoate in the composition comprises at least one of a sodium β-hydroxypentanoate salt, calcium β-hydroxypentanoate salt, or magnesium β-hydroxypentanoate salt.
12. The method of claim 1 , wherein administering the composition at least one of increases mental performance levels, or increases physical performance levels, or lowers exertion during exercise in the individual.
13. The method of claim 1 wherein the β-hydroxypentanoate comprises at least one of a sodium β-hydroxypentanoate salt, calcium β-hydroxypentanoate salt, or magnesium β-hydroxypentanoate.
14. The method of claim 1 wherein the β-hydroxypentanoate in the composition comprises β-hydroxypentanoate salts.
15. The method of claim 9 wherein administration of the composition increases blood glucose levels.
16. The method of claim 9 wherein the β-hydroxypentanoate comprises at least one of a sodium β-hydroxypentanoate salt, calcium β-hydroxypentanoate salt, or magnesium β-hydroxypentanoate.
17. The method of claim 9 , wherein the β-ketopentanoate comprises at least one of a sodium β-ketopentanoate salt, calcium β-ketopentanoate salt, or magnesium β-ketopentanoate salt.
18. The method of claim 10 wherein the β-ketopentanoate in the composition comprises at least one of a sodium β-ketopentanoate salt, calcium β-ketopentanoate salt, or magnesium β-ketopentanoate salt.
19. The method of claim 10 wherein the β-hydroxypentanoate consists essentially of R-β-hydroxypentanoate.
20. The method of claim 10 wherein the β-hydroxypentanoate consists essentially of L-β-hydroxypentanoate.