Treatment of disease with relaxin
The present invention relates to relaxin or a homologue or variant thereof for use in a method of treating an inflammatory condition, for example an autoimmune inflammatory condition. The invention also relates to the treatment of an inflammatory condition, for example an autoimmune inflammatory condition comprising administering to a subject in need thereof a relaxin, or a homologue or variant thereof. Such conditions may be CNS conditions or be organ specific.
1. A method of treating traumatic spinal cord injury comprising administering an effective amount of relaxin selected from human relaxin 1 and relaxin 2, a homologue selected from prorelaxin and preprorelaxin or variant thereof to a subject in need thereof, wherein the relaxin, the homologue or the variant thereof is a polypeptide, wherein the variant thereof has at least 95% similarity or identity to the relaxin or the homologue, and wherein administration of the relaxin, the homologue or the variant thereof reduces the levels of IL-6 and IL-17 in the spinal cord and brain, reduces demyelination, preserves neurofilaments, protects neurons, and stops or reverses gliosis.
2. The method according to claim 1 , wherein the method further comprises the administration of estrogen.
3. The method according to claim 1 , wherein the variant thereof has at least 98% similarity or identity to the relaxin or the homologue.