IP Library Granted Patent US 11,344,686
Granted Patent B2
US 11,344,686 · App. 16/937,063 · Granted May 31, 2022

Method of respiratory system treatment

Inventors: Donald M. Pell (St. Petersburg, FL); Frank Caiazzo (Brooksville, FL); Paula Pell (St. Petersburg, FL); Govindan P. Nair (Seminole, FL); Michael P. Spuza (Largo, FL)
Assignee: BN INTELLECTUAL PROPERTIES, INC.
A61M15/0085A61L2/0094A61L2/24A61M11/005A61L2202/14A61L2202/15A61M15/0021A61M2205/0294A61M2205/18A61M2205/3592A61M2205/50A61M2205/581A61M2205/582A61M2205/587A61M2205/8206
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Quick Facts
Patent No.
US 11,344,686
App. No.
16/937,063
Granted
May 31, 2022
Kind
B2
Abstract

A method of treating respiratory system tissue, includes operations of generating a plume of particles of a treating solution from a nebulizer, inhaling particles of the treating solution, delaying exhalation of an inhalation having particles of the treating solution therein, and determining whether a dose of the treating solution has been delivered, wherein the treating solution is a solution of at least 40% ethyl alcohol, by volume.

Claims (39)

1. A method of treating a patient's respiratory system tissue, comprising:

generating a plume of particles of a treating solution from a nebulizer, wherein

the nebulizer generates the plume of particles for a vibrational time period,

the treating solution is a solution of at least 40% ethyl alcohol, by volume, and

the particles comprising the plume of particles have a diameter greater than 10 micrometers (μm)

applying the plume of particles to the patient's respiratory system solely through the patient's nose during an intermediate portion of the patient's inhalation;

pausing the patient's respiration for 3-10 seconds to allow a first volume of the particles to deposit on the patient's respiratory system tissue;

removing an undeposited portion of the particles from the patient's respiratory system by exhalation;

determining whether the first volume of deposited particles comprises a treatment volume sufficient to induce germicidal action on the patient's respiration system tissue; and

if the treatment volume has not been reached, repeating the operations of applying the plume of particles to the patient's respiratory system, pausing the patient's respiration, and removing the undeposited portion of the particles from the patient's respiratory system until the treatment volume has been reached.

2. The method of claim 1 , further comprising

determining whether the treatment volume of the treating solution has been delivered to the patient's respiratory system based on a total of the vibrational time periods used to generate the plume of particles of the treatment solution during the operation of applying the plume of particles to the patient's respiratory system.

3. The method of claim 1 , wherein generating a plume of particles of a treating solution from a nebulizer further comprises generating a plume of particles of a treating solution from a pot-type nebulizer.

4. The method of claim 1 , wherein generating a plume of particles of a treating solution from a nebulizer further comprises generating a plume of particles of a treating solution from an active mesh nebulizer having a vibratable piezoelectric plate therein.

5. The method of claim 1 ,

wherein determining whether the treatment volume of the treating solution has been delivered further comprises monitoring a solution level in a reservoir of a nebulizer, and further comprising halting treatment when the treatment volume of the treating solution has been delivered.

6. The method of claim 5 , wherein determining whether the treatment volume of the treating solution has been delivered further comprises determining that a patient has inhaled at least 1 milliliter (ml) of the treating solution from the nebulizer.

7. The method of claim 1 , wherein determining whether the treatment volume of the treating solution has been delivered further comprises deactivating the nebulizer after not more than five activations of a vibratable piezoelectric plate in the nebulizer.

8. The method of claim 7 , wherein determining whether the treatment volume of the treating solution has been delivered further comprises determining that the not more than five activations of the vibratable piezoelectric plate in the nebulizer have nebulized at least 0.2 milliliter (ml) of the treating solution, and determining that the particles from the not more than five activations have been inhaled by a patient.

9. The method of claim 1 , wherein generating a plume of particles of a treating solution from a nebulizer further comprises generating a plume of particles of a treating solution comprising at least 60% ethyl alcohol, by volume.

10. The method of claim 1 , wherein generating a plume of particles of a treating solution from a nebulizer further comprises generating a plume of particles of a treating solution comprising at least 70% ethyl alcohol, by volume.

11. The method of claim 1 , wherein generating a plume of particles of a treating solution from a nebulizer further comprises generating a plume of particles of a treating solution comprising at least 80% ethyl alcohol, by volume.

12. The method of claim 1 , further comprising:

selecting a portion of the patient's respiratory system for treatment; and

selecting, based on the selected portion of the respiratory system, a nebulizer configured to produce the plume of particles targeting the selected portion of the respiratory system.

13. The method of claim 1 , further comprising

detecting particles on respiratory system tissues; and

regulating inhaling particles of the treating solution by changing inhalation speed.

14. The method of claim 1 , further comprising

detecting irritation in the nasal passages during inhaling the particles; and

regulating inhaling particles of the treating solution by decreasing inhalation speed.

15. The method of claim 1 , further comprising

detecting irritation in the nasal passages during inhaling the particles; and

regulating inhaling particles of the treating solution by increasing inhalation speed.

16. The method of claim 1 , further comprising

detecting irritation in the nasal passages during inhaling the particles; and

regulating particle distribution by changing a duration of inhaling particles of the treating solution.

17. The method of claim 16 , further comprising wherein changing the duration of inhaling the particles further comprises increasing the duration of inhaling the particles.

18. The method of claim 16 , further comprising decreasing the duration of inhaling the particles.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 23, 2020
From: PELL, DONALD M; CAIAZZO, FRANK; PELL, PAULA; NAIR, GOVINDAN P; SPUZA, MICHAEL P
To: BN INTELLECTUAL PROPERTIES, INC.
Reel/Frame 053295/0575 →
Continuity (2)
Continuation In Part 16230992 · Dec 21, 2018
Related Publication 20200353187A1 · Nov 12, 2020
Cited By (1)
US 12,194,037