Pressure-regulating implant and methods of use thereof
Provided is an implant, including a chamber having an interior radius wherein the interior radius has a flange, a cover slip, a cup, a setting member, a securing member, a resistance member, and an opposing member, wherein the cover slip, cup, resisting member, and setting member are attached to one another, the setting member sets on a flange and the securing member secures the setting member to the flange, the resistance member includes a flexibility and a longitudinal axis with a length wherein the flexibility permits modification of the length, and the opposing member sets a minimum length of the longitudinal axis. Also provided is a method of using said implant including affixing the chamber to a skull of a mammal.
1. An implant, comprising
a chamber having an interior radius wherein the interior radius has a flange,
a cover slip, a cup, a setting member, a securing member,
a resistance member, and an opposing member,
wherein the cover slip, cup, resistance member, and setting member are attached to one another and the cup, resistance member, and setting member are on a same side of the cover slip as one another,
the setting member sets on the flange and the securing member secures the setting member to the flange,
the resistance member comprises a flexibility and a longitudinal axis with a length wherein the flexibility permits modification of the length,
the opposing member sets a minimum length of the longitudinal axis, and
the cover slip comprises a window for observing tissue.
2. The implant of claim 1 , wherein the resistance member comprises a hydrogel, one or more springs, silicone, or rubber.
3. The implant of claim 2 , wherein the resistance member comprises one or more springs and the implant further comprises a protective cover between the one or more springs and the cup.
4. The implant of claim 3 wherein the opposing member comprises one or more screws extending from the setting member and abutting the cup or the protective cover.
5. The implant of claim 1 wherein the resistance member comprises a silicone and the silicone comprises a weight ratio of hybrid vinyl-functional siloxane polymer mix (P) to platinum catalyst (C) to silicone-based oil (O) and the weight ratio of P:C:O is 2:10:30.
6. The implant of claim 1 wherein a Young's Modulus of the resistance member is between 0.5-1.0 kPa.
7. The implant of claim 1 further comprising a cap.
8. The implant of claim 1 wherein the opposing member comprises one or more screws extending from the setting member and abutting the cup.
9. The implant of claim 1 wherein an outer radius of the setting member comprises setting member threads and the inner radius comprises chamber threads and the setting member threads mate with the chamber threads.
10. The implant of claim 1 wherein the inner radius comprises slots and an outer radius of the setting member comprises tabs and the setting member tabs mate with the slots.
11. A method of using the implant of claim 1 comprising affixing the chamber to a skull of a mammal.
12. The method of claim 11 wherein the mammal is a primate.
13. The method of claim 11 wherein the chamber is affixed to the skull for at least 6 months.
14. The method of claim 11 wherein the chamber is affixed to the skull for at least 12 months.
15. An implant, comprising
a cover slip, a cup, a setting member, a resistance member, and an opposing member, wherein
the cup, resistance member, and setting member are on a same side of the cover slip as one another,
the resistance member comprises a flexibility and a longitudinal axis with a length and the opposing member sets a minimum length of the longitudinal axis, and
the cover slip comprises a window for observing tissue.
16. The implant of claim 15 , wherein the resistance member comprises a hydrogel, one or more springs, silicone, or rubber.
17. The implant of claim 15 , wherein the resistance member is a hydrogel.
18. The implant of claim 15 wherein the resistance member is one or more springs.
19. The implant of claim 15 , wherein the resistance member is silicone.
20. The implant of claim 15 wherein the opposing member comprises one or more screw having a head and the one or more screws are configured to extend between an inner surface of a bone and an outer surface of the setting member.
21. The implant of claim 20 wherein the setting member is configured to be located between the one or more head and the bone.
22. The implant of claim 20 wherein the one or more head and the setting member are configured to be located on opposite sides of the bone.
23. A method of using the implant of claim 15 comprising implanting the implant in a mammal between a brain and a skull of the mammal.
24. The method of claim 23 wherein the mammal is a primate.
25. The method of claim 23 wherein the implant is implanted for at least 6 months.
26. The method of claim 23 wherein the implant is implanted for at least 12 months.