IP Library › Granted Patent US 11,357,755

Granted Patent B2

US 11,357,755 · App. 17/256,867 · Granted Jun 14, 2022

Compounds for controlling arthropods

Inventors: Joachim Telser (Wuppertal, DE); Ursula Krenz (Leichlingen, DE); Kirsten Boerngen (Cologne, DE); Andreas Turberg (Haan, DE); Klein Sofia (Cologne, DE); Franziska Schmidt (Duesseldorf, DE)

Assignee: Bayer Animal Health GmbH

A61K31/4155 A61K9/0019 A61K31/415 A61P33/14 C07C69/96 C07D231/12

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Quick Facts

Patent No.: US 11,357,755
App. No.: 17/256,867
Granted: Jun 14, 2022
Kind: B2

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USPTO Patent Center↗ Full Patent PDF↗

Abstract

The present invention relates to novel halogen-substituted compounds, to processes for their preparation and to their use for controlling animal pests, in particular arthropods and especially insects and arachnids.

Claims (162)

1. A compound of formula (I)

wherein

Q is O or absent;

L 1 is linear C 2 -C 4 alkanediyl, which is optionally substituted with one or more groups independently selected from the group consisting of halogen, C 1 -C 4 alkyl and C 3 -C 6 cycloalkyl, wherein two C 1 -C 4 -alkyl substituents may form a ring together with the carbon atom to which they are bonded; or

is a moiety (CH 2 ) n —X—(CH 2 ) m wherein

n and m are independently 0, 1 or 2 and

X is C 3 -C 7 -cycloalkanediyl, which is optionally substituted with C 1 -C 4 alkyl; or

L 1 is absent;

with the proviso that in the case of L 1 being absent, Q is also absent;

L 2 is C═O or absent,

L 3 is linear C 1 -C 4 alkanediyl, which is optionally substituted with one or more groups independently selected from the group consisting of C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl and halogen, wherein two C 1 -C 4 -alkyl substituents may form a ring together with the carbon atom to which they are bonded; or

is a group (CH 2 ) n —(CH═CH)—CH 2 ) m , which is optionally substituted with up to 2 groups independently selected from the group consisting of C 1 -C 4 alkyl, C 3 -C 5 cycloalkyl and halogen, wherein

n and m are independently 0, 1 or 2; or

is C 3 -C 7 -cycloalkanediyl, which is optionally substituted with one or more groups independently selected from the group consisting of C 1 -C 4 -alkyl and halogen;

Y is selected from T 1

wherein

R 1 , R 2 and R 3 are each independently selected from the group consisting of hydrogen, halogen, cyano, nitro, linear or branched C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 6 -alkoxy, linear or branched halogen-substituted C 1 -C 6 -alkyl, halogen-substituted C 1 -C 6 -alkoxy, halogen substituted C 3 -C 6 -cycloalkyl, C 1 -C 6 -alkylsulphanyl, C 1 -C 6 -alkylsulphinyl, C 1 -C 6 -alkylsulphonyl, N—C 1 -C 6 -alkylamino, N,N-di-C 1 -C 6 -alkylamino, N—C 1 -C 3 -alkoxy-C 1 -C 4 -alkylamino and 1-pyrrolidinyl

or T 2

wherein

Z 1 and Z 2 are each independently selected from the group consisting of hydrogen, halogen, cyano, nitro, linear or branched C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylcarbonyl, halogen-substituted linear or branched C 1 -C 6 -alkyl, halogen-substituted C 1 -C 6 -alkoxy, halogen substituted C 3 -C 6 -cycloalkyl, C 1 -C 6 -alkylsulphanyl, C 1 -C 6 -alkylsulphinyl, C 1 -C 6 -alkylsulphonyl, N—C 1 -C 6 -alkylamino, N,N-di-C 1 -C 6 -alkylamino, N—C 1 -C 3 -alkoxy-C 1 -C 4 -alkylamino and 1-pyrrolidinyl; and

Z 3 represents hydrogen or linear C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, aryl or hetaryl, which may independently of one another be substituted with 1 to 5 substituents selected from the group consisting of hydroxy, halogen, cyano, nitro, amino, C 1 -C 3 -alkyl, C 1 -C 3 -alkoxy, hydroxycarbonyl, alkoxycarbonyl, alkylcarbamoyl, cycloalkylcarbamoyl and phenyl

or a salt thereof.

2. The compound according to claim 1 , wherein

Q is O;

L 2 is C═O;

L 3 is a group (CH 2 ) n —(CH═CH)—CH 2 ) m , which is optionally substituted with up to 2 groups independently selected from the group consisting of C 1 -C 4 alkyl, C 3 -C 5 cycloalkyl and halogen, wherein

n and m are independently 0, 1 or 2;

or a salt thereof.

3. The according to claim 1 , wherein

Q is O;

L 2 is C═O;

L 3 is a group (CH 2 ) n —(CH═CH)—CH 2 ) m , wherein n and m are 0;

or a salt thereof.

4. The compound according to claim 1 , wherein

Q is O

L 2 is C═O

or a salt thereof.

5. The compound according to claim 1 , wherein

Q is O;

L 2 is absent;

or a salt thereof.

6. The compound according to claim 1 , wherein

L 1 , L 2 and Q are absent;

or a salt thereof.

7. The compound according to claim 1 , wherein one or more of the following conditions apply

Q is O;

and/or

L 1 is linear C 2 -C 4 alkanediyl, which is optionally substituted with one or more C 1 -C 4 alkyl groups, wherein two C 1 -C 4 -alkyl substituents may form a ring together with the carbon atom to which they are bonded

and/or

L 2 is C═O

and/or

n and m are independently 0, 1 or 2

or a salt thereof.

8. The compound according to claim 1 , wherein

Y is selected from T 1

wherein

R 1 , R 2 and R 3 are each independently selected from the group consisting of hydrogen, halogen, linear or branched C 1 -C 3 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 3 -alkoxy, linear or branched halogen-substituted C 1 -C 3 -alkyl, halogen-substituted C 1 -C 3 -alkoxy, halogen substituted C 3 -C 6 -cycloalkyl, and 1-pyrrolidinyl,

or T 2

wherein

Z 1 represents linear or branched C 1 -C 3 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 3 -alkoxy, which may independently of one another be substituted with 1 to 5 substituents selected from the group consisting of hydroxy, halogen, cyano, nitro, C 1 -C 3 -alkyl, and C 1 -C 3 -alkoxy,

Z 2 represents halogen, cyano, nitro, amino, or linear or branched C 1 -C 6 -alkyl, C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -alkylsulphanyl, C 1 -C 6 -alkylsulphinyl, C 1 -C 6 -alkylsulphonyl, which may independently of one another be substituted with 1 to 5 substituents selected from the group consisting of hydroxy, halogen, cyano, nitro, C 1 -C 3 -alkyl, and C 1 -C 3 -alkoxy;

and

Z 3 represents hydrogen or linear or branched C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, aryl or hetaryl, which may independently of one another be substituted with 1 to 5 substituents selected from the group consisting of hydroxy, halogen, cyano, nitro, C 1 -C 3 -alkyl, and C 1 -C 3 -alkoxy;

or a salt thereof.

9. The compound according to claim 1 , wherein

Y is selected from T 1

wherein

R 1 is halogen;

R 2 is linear or branched C 1 -C 3 -alkyl substituted with 1 to 7 halogen; and

R 3 is C 1 -C 3 -alkoxy substituted with 1 to 3 halogen;

or T 2

wherein

Z 1 represents linear or branched C 1 -C 3 -alkyl or C 3 -C 6 -cycloalkyl, substituted with 1 to halogen substituents;

Z 2 represents linear or branched C 1 -C 3 -alkyl substituted with 1 to 3 halogen substituents, or

Z 2 represents nitro, methylsulphanyl, methylsulphinyl, methylsulphonyl, fluorine, chlorine, bromine, iodine; and

Z 3 represents hydrogen or linear or branched C 1 -C 6 -alkyl, linear or branched C 1 -C 6 -alkyl;

or a salt thereof.

10. The compound according to claim 1 , wherein T1 is represented by one of the following groups T1-1, T1-2 or T1-3:

11. A pharmaceutical composition comprising the compound according to claim 1 .

12. The pharmaceutical composition according to claim 11 , further comprising at least one component selected from the group consisting of pharmaceutically acceptable auxiliaries, excipients, solvents and additional pharmaceutically active agents.

13. The pharmaceutical composition according to claim 12 which is formulated for use in subcutaneous or oral application.

14. A method for controlling one or more parasites on animals comprising administering to the animals the compound of claim 1 or a pharmaceutical composition thereof.

15. A process for preparing the compound according to claim 1 comprising reacting a compound (A)

with a group (B)

wherein

PG 1 represents a protecting group or hydrogen to form the compounds according to formula (I), and wherein in cases wherein PG 1 is not hydrogen, deprotection is carried out to form the compounds (I);

wherein the process further comprises preparing the group (B) by

i) reacting a compound (IIa) with a compound (IIIa) to form compound (Va), wherein PG 2 is a protecting group or hydrogen, and wherein in cases wherein PG 2 is not hydrogen (Va) is obtained by selectively cleaving PG 2 :

wherein PG 1 represents a protecting group or hydrogen;

ii) reacting a compound (VI) with compound (IIIb) to form compound (Vb), wherein PG 2 is a protecting group or hydrogen, and wherein in cases wherein PG 2 is not hydrogen (Vb) is obtained by selectively cleaving PG 2 :

and wherein PG 1 represents a protecting group or hydrogen.

16. An intermediate compound according to formula (B),

(B)

wherein

Q is O;

L 2 is C═O;

is a moiety (CH 2 ) n —X—(CH 2 ) m wherein

n and m are independently 0, 1 or 2 and

X is C 3 -C 7 -cycloalkanediyl, which is optionally substituted with C 1 -C 4 alkyl; or

L 1 is absent;

with the proviso that in the case of L 1 being absent, Q is also absent;

n and m are independently 0, 1 or 2; or

is C 3 -C 7 -cycloalkanediyl, which is optionally substituted with one or more groups independently selected from the group consisting of C 1 -C 4 -alkyl and halogen;

PG 1 represents a tert-butyl group

according to formula (C),

wherein

Q is O or absent;

is a moiety (CH 2 ) n —X—(CH 2 ) m wherein

n and m are independently 0, 1 or 2 and

X is C 3 -C 7 -cycloalkanediyl, which is optionally substituted with C 1 -C 4 alkyl; or

L 1 is absent;

with the proviso that in the case of L 1 being absent, Q is also absent;

L 2 is C═O or absent,

n and m are independently 0, 1 or 2; or

is C 3 -C 7 -cycloalkanediyl, which is optionally substituted with one or more groups independently selected from the group consisting of C 1 -C 4 -alkyl and halogen;

Y is selected from T 1

wherein

or T 2

wherein

and wherein PG 1 represents a tert-butyl group.

17. The compound according to claim 7 , wherein n and m are 0.

18. The compound according to claim 8 , wherein

R 1 , R 2 and R 3 are each independently selected from the group consisting of halogen, linear or branched halogen-substituted C 1 -C 3 -alkyl, and halogen-substituted C 1 -C 3 -alkoxy;

Z 1 represents linear or branched C 1 -C 3 -alkyl or C 3 -C 6 -cycloalkyl, which may independently of one another be substituted with 1 to 5 halogen substituents;

Z 2 represents linear or branched C 1 -C 3 -alkyl, which may be substituted with 1 to 5 halogen substituents, optionally with 1 to 3 halogen substituents; and/or

Z 3 represents hydrogen or linear or branched C 1 -C 6 -alkyl which may be substituted with 1 to 5 substituents selected from the group consisting of hydroxy, halogen, C 1 -C 3 -alkyl, and C 1 -C 3 -alkoxy.

19. The compound according to claim 18 , wherein

Z 2 represents trifluormethyl, or

Z 2 represents nitro, methylsulphanyl, methylsulphinyl, methylsulphonyl, fluorine, chlorine, bromine, or iodine.

20. The compound according to claim 9 , wherein Y is T 1

wherein

R 1 is selected from the group consisting of fluorine, bromine or chlorine;

R 2 is linear or branched C 1 -C 3 -alkyl substituted with 1 to 7 fluorine; and/or

R 3 is C 1 -C 3 -alkoxy substituted with 1 to 3 fluorine.

21. The compound according to claim 19 , wherein

R 1 is chlorine;

R 2 is CF 3 , C 2 F 5 or C 3 F 7 ; and/or

R 3 is OCF 3 , O 2 F 5 or OC 3 F 7 .

22. The compound according to claim 9 , wherein Y is T 2

wherein

Z 1 represents trifluoromethyl, 1-chlorocyclopropyl, 1-fluorocyclopropyl or pentafluoroethyl;

Z 2 represents nitro, methylsulphanyl, methylsulphinyl, methylsulphonyl, fluorine, chlorine, bromine, iodine, or linear or branched C 1 -C 3 -alkyl substituted with 1 to 3 fluorine;

and/or

Z 3 represents hydrogen, methyl, ethyl, or n-propyl.

23. The compound according to claim 21 , wherein

Z 1 represents trifluoromethyl or pentafluoroethyl; and/or

Z 2 represents trifluoromethyl.

24. The product according to claim 14 , wherein the parasites are insects or arachnids on companion animals.

Assignments (1)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 14, 2021

From: TELSER, JOACHIM; BOERNGEN, KIRSTEN; KRENZ, URSULA; TURBERG, ANDREAS; KLEIN, SOFIA; SCHMIDT, FRANZISKA

To: BAYER ANIMAL HEALTH GMBH

Reel/Frame 055916/0100 →

Priority Claims (1)

EP 18181950 · Jul 5, 2018 · regional

Continuity (1)

Related Publication 20220008391A1 · Jan 13, 2022