Inorganic-organic composite medical material and method for producing inorganic-organic composite medical material
An inorganic-organic composite medical material includes a two-phase co-continuous structure of an inorganic substance having open pores and an organic polymer filling the open pores, wherein the open pores have an average pore diameter of 1 nm or more and 100 nm or less, and the inorganic substance has a specific surface area of 100 m 2 /g or less.
1. An inorganic-organic composite medical material comprising:
a two-phase co-continuous structure of an inorganic substance having open pores and an organic polymer filling the open pores,
wherein the inorganic substance includes a skeleton, in which particles of a plurality of metal oxide are bonded together and which is metal oxide glass of a continuous three-dimensional network,
the open pores are a space portion formed in a three-dimensional network and defined by the skeleton,
the open pores have an average pore diameter of 1 nm or more and 100 nm or less, and
the inorganic substance has a specific surface area of 100 m 2 /g or less.
2. The inorganic-organic composite medical material according to claim 1 , wherein
the organic polymer is a polymer of an ingredient monomer having an ethylenic unsaturated double bond.
3. A method for producing an inorganic-organic composite medical material, the method comprising the steps of:
dispersing inorganic nanoparticles which are particles of metal oxide in a dispersion medium,
drying the dispersion medium to form a porous precursor having nanopores from the inorganic nanoparticles,
calcining the porous precursor to form an inorganic calcined substance having a skeleton, in which the inorganic nanoparticles are bonded together, and open pores, which are a space portion defined by the skeleton, with an average pore diameter of 1 nm or more and 100 nm or less, and having a specific surface area of 100 m 2 /g or less, and
filling the open pores of the inorganic calcined substance with an organic polymer, thereby producing an inorganic-organic composite medical material having a two-phase co-continuous structure of the inorganic substance having open pores and the organic polymer filling the open pores.
4. The method for producing an inorganic-organic composite medical material according to claim 3 , wherein
in the step of dispersing the inorganic nanoparticles in the dispersion medium,
a water-soluble polymer is blended in the dispersion medium along with the inorganic nanoparticles to disperse the inorganic nanoparticles in the dispersion medium,
in the step of forming the porous precursor,
the dispersion medium is dried to form the porous precursor having nanopores based on the water-soluble polymer from the inorganic nanoparticles and the water-soluble polymer.
5. The method for producing an inorganic-organic composite medical material according to claim 3 , wherein
in the step of forming the inorganic calcined substance,
the porous precursor is calcined at a short calcining time shorter than a calcining time where the inorganic calcined substance is formed into a compact inorganic calcined substance having no open pore.
6. The method for producing an inorganic-organic composite medical material according to claim 5 , wherein
the average pore diameter of the open pores is adjusted to be in the range of 1 nm or more and 100 nm or less by the short calcining time.
7. The method for producing an inorganic-organic composite medical material according to claim 3 , wherein
the step of filling the open pores of the inorganic calcined substance with the organic polymer includes
introducing an ingredient monomer of the organic polymer in the open pores, and
polymerizing the ingredient monomer introduced in the open pores to form the organic polymer.