MDMA treatment to enhance acute emotional effects profile of LSD, psilocybin or other psychedelics

1. A method of enhancing positive therapeutic effects of a psychedelic, including the steps of:

administering an empathogen/entactogen and a psychedelic in a same single oral dosage form to an individual, wherein the empathogen/entactogen induces a positive psychological state in the individual and is administered in a dose of 20-200 mg; and

enhancing a positive response to the psychedelic.

2. The method of claim 1 , wherein the empathogen/entactogen and psychedelic have different release profiles.

3. The method of claim 1 , wherein the psychedelic is chosen from the group consisting of psilocybin, psilocin, lysergic acid diethylamide (LSD), mescaline, dimethyltryptamine (DMT), 2,5-dimethoxy-4-iodoamphetamine (DOI), 2,5-dimethoxy-4-bromoamphetamine (DOB), phenethylamine or tryptamine psychedelics, salts thereof, analogs thereof, prodrugs thereof, and homologues thereof.

4. The method of claim 1 , wherein the psychedelic is LSD and is administered in a dose of 0.05-0.3 mg.

5. The method of claim 1 , wherein the empathogen/entactogen is chosen from the group consisting of 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylendioxyamphetamine (MDA), 3,4,-methylenedioxyethylamphetamine (MDEA), 5,6-methylenedioxy-2-aminoindane (MDAI), mephedrone, methylone, 3-methylmethcathinone (3-MMC), homologues thereof, analogues thereof, and prodrugs thereof.

6. The method of claim 1 , wherein the psychedelic is a short-acting psychedelic.

7. The method of claim 1 , wherein the individual has a psychiatric disorder chosen from the group consisting of depression, anxiety, anxiety related to life-threatening disease, obsessive-compulsive disorder, personality disorder, and addiction.

8. The method of claim 1 , wherein said enhancing step further includes the step of reducing bad drug effects chosen from the group consisting of anxiety, fear, fear of loss of body control, anxious-ego dissolution, disembodiment, fear of impaired thought control, paranoia, panic, negative thoughts, grooming, nadir effects, and combinations thereof.

9. The method of claim 1 , wherein said enhancing step further includes the step of improving good drug effects chosen from the group consisting of drug linking, oceanic boundlessness, experience of unity, spiritual experience, blissful state, insightfulness, connectedness, mystical experiences, mystical-type effects, positive mood, transcendence of time/space, ineffability, well-being, trust, feelings of love, feeling open, peak experience, and combinations thereof.

10. The method of claim 1 , wherein the empathogen/entactogen reduces anxiety up to 6 hours after administration.

11. A composition comprising an empathogen/entactogen and a psychedelic in the same single oral dosage form.

12. The composition of claim 11 , wherein said empathogen/entactogen and said psychedelic have different release profiles.

13. The composition of claim 11 , wherein said empathogen/entactogen is chosen from the group consisting of 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylendioxyamphetamine (MDA), 3,4,-methylenedioxyethylamphetamine (MDEA), 5,6-methylenedioxy-2-aminoindane (MDAI), mephedrone, methylone, 3-methylmethcathinone (3-MMC), homologues thereof, analogues thereof, and prodrugs thereof.

14. The composition of claim 13 , wherein said empathogen/entactogen is MDMA and is present in a dose of 20-200 mg.

15. The composition of claim 11 , wherein said psychedelic is chosen from the group consisting of psilocybin, psilocin, lysergic acid diethylamide (LSD), mescaline, dimethyltryptamine (DMT), 2,5-dimethoxy-4-iodoamphetamine (DOI), 2,5-dimethoxy-4-bromoamphetamine (DOB), phenethylamine or tryptamine psychedelics, salts thereof, analogs thereof, prodrugs thereof, and homologues thereof.

16. The composition of claim 15 , wherein said psychedelic is LSD and is present in a dose of 0.05-0.3 mg.