Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
The present invention relates to combinations comprising a positive allosteric modulator (“PAM”) of metabotropic glutamatergic receptor subtype 2 (“mGluR2”) or a pharmaceutically acceptable salt or a solvate thereof, or an orthosteric agonist of metabotropic glutamatergic receptor subtype 2 compound or a pharmaceutically acceptable salt or a solvate thereof, and a synaptic vesicle protein 2A (“SV2A”) ligand.
1. A method for the treatment of epilepsy comprising administering to a patient in need thereof a therapeutically effective amount of:
(a) a synaptic vesicle protein 2A (“SV2A”) ligand selected from the group consisting of levetiracetam and brivaracetam; and
(b)
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 wherein the SV2A ligand is levetiracetam.
3. The method of claim 1 wherein the SV2A ligand is brivaracetam.
4. The method of claim 1 wherein the SV2A ligand and Compound 6b or a pharmaceutically acceptable salt thereof are administered simultaneously.
5. The method of claim 1 wherein the SV2A ligand and Compound 6b or a pharmaceutically acceptable salt thereof are administered separately.
6. The method of claim 1 wherein the SV2A ligand and Compound 6b or a pharmaceutically acceptable salt thereof are administered sequentially.
7. The method of claim 1 wherein the epilepsy is partial onset seizures or focal onset seizures.
8. The method of claim 1 wherein the epilepsy is myoclonic seizures.
9. The method of claim 1 wherein the epilepsy is primary generalized tonic-clonic seizures.
10. The method of claim 1 wherein the epilepsy is treatment resistant epilepsy.
11. The method of claim 1 , comprising administering to the patient a therapeutically effective amount of (a) the SV2A ligand; and
(b) Compound 6b.
12. The method of claim 11 wherein the SV 2 A ligand is levetiracetam.
13. The method of claim 11 wherein the SV 2 A ligand is brivaracetam.
14. The method of claim 11 wherein the SV 2 A ligand and Compound 6 b or a pharmaceutically acceptable salt thereof are administered simultaneously.
15. The method of claim 11 wherein the SV2A ligand and Compound 6 b or a pharmaceutically acceptable salt thereof are administered separately.
16. The method of claim 11 wherein the SV2A ligand and Compound 6 b or a pharmaceutically acceptable salt thereof are administered sequentially.
17. The method of claim 11 wherein the epilepsy is partial onset seizures or focal onset seizures.
18. The method of claim 11 wherein the epilepsy is myoclonic seizures.
19. The method of claim 11 wherein the epilepsy is primary generalized tonic-clonic seizures.
20. The method of claim 11 wherein the epilepsy is treatment resistant epilepsy.