Brain stimulating device and use thereof
The present invention relates to a brain stimulating device and, particularly, relates to a brain stimulating device comprising: a brainwave measurement unit for outputting a brainwave signal; and a stimulation unit for applying spindle-like stimulation to a brain in accordance with the generation of slow oscillation included in the brainwave signal. The brain stimulating device according to the present invention can reinforce memory or reduce memory deterioration due to dementia. Also, the brain stimulating device according to the present invention can reinforce hippocampus-dependent memory. Further, a portable device according to the present invention can control and monitor the brain stimulating device. Moreover, a method for assessing the performance of the brain stimulating device according to the present invention can assess the performance of the brain stimulating device.
1. A method for enhancing memory, the method comprising:
(a) measuring an EEG signal of a brain; and
(b) applying a spindle-like stimulation to the brain in response to a generation of a slow oscillation included in the EEG signal,
wherein the spindle-like stimulation comprises a spindle component and a slow oscillation component,
wherein the spindle component has an envelope of the slow oscillation component,
wherein the frequency of the spindle component of the spindle-like stimulation is within a frequency range from 11 to 16 Hz, and the frequency of the slow oscillation component of the spindle-like stimulation is less than 1 Hz, and
wherein the slow oscillation component of the spindle-like stimulation is substantially in-phase with the slow oscillation of the EEG signal.
2. The method of claim 1 , wherein the applying the spindle-like stimulation to the brain is performed by a focused ultrasound element.
3. The method of claim 1 , wherein the applying the spindle-like stimulation to the brain comprises:
(i) receiving an input of the EEG signal, and filtering a signal corresponding to a frequency band of the slow oscillation;
(ii) detecting the generation of the slow oscillation from an output of the filtered signal, and outputting a slow oscillation detection signal;
(iii) outputting an up-state signal corresponding to the up-state of the slow oscillation in response to the slow oscillation detection signal;
(iv) generating a stimulation control signal during the output of the up-state signal; and
(v) applying the spindle-like stimulation to the brain in response to the stimulation control signal.