Two-phase oral care whitening compositions
A two-phase oral care whitening composition including a hydrophobic phase and a hydrophilic phase, and methods for oral care whitening teeth with the same are provided. The hydrophobic phase may include a source of hydrogen peroxide and an acyl donor. The hydrophilic phase may include an enzyme that catalyzes the generation of peracetic acid between the source of hydrogen peroxide and the acyl donor. At least one of the hydrophobic phase and the hydrophilic phase may further include at least one surfactant.
1. A two-phase oral care whitening composition, comprising:
a hydrophobic phase comprising a source of hydrogen peroxide; a nonionic surfactant; and an acyl donor; and
a hydrophilic phase comprising an amphoteric surfactant; an enzyme that catalyzes the generation of peracetic acid between the source of hydrogen peroxide and the acyl donor, and
wherein when the hydrophobic phase and the hydrophilic phase are combined the resulting oral care product has a viscosity of from about 75,000 cP to about 200,000 cP.
2. The two-phase oral care whitening composition of claim 1 , wherein the nonionic surfactant is a sorbitan ester.
3. The two-phase oral care whitening composition of claim 1 , wherein the amphoteric surfactant is cocamidopropyl betaine.
4. The two-phase oral care whitening composition of claim 1 , wherein the acyl donor is triacetin.
5. The two-phase oral care whitening composition of claim 1 , wherein the hydrophilic phase further comprises a thickener.
6. The two-phase oral care whitening composition of claim 5 , wherein the thickener is a carboxypolymethylene.
7. The two-phase oral care whitening composition of claim 1 , wherein the source of hydrogen peroxide is a cross-linked polyvinylpyrrolidone (PVP) hydrogen peroxide complex.
8. The two-phase oral care whitening composition of claim 1 , wherein the enzyme has perhydrolytic activity and is configured to generate peracetic acid via enzyme-catalyzed perhydrolysis.
9. The two-phase oral care whitening composition of claim 1 , wherein the enzyme comprises a CE-7 signature motif that aligns with SEQ ID NO: 2, the CE-7 signature motif comprising a) an RGQ motif at positions corresponding to positions 118-120 of SEQ ID NO: 2; b) a GXSQG (SEQ ID NO: 3) motif at positions corresponding to positions 179-183 of SEQ ID NO: 2 and an HE motif at positions corresponding to positions 298-299 of SEQ ID NO:2.
10. The two-phase oral care whitening composition of claim 1 , wherein the enzyme comprises an amino acid sequence comprising a CE-7 signature motif and having at least 80% amino acid sequence identity to SEQ ID NO: 1.
11. The two-phase oral care whitening composition of claim 1 , wherein the enzyme comprises SEQ ID NO: 1.
12. A method for whitening teeth, comprising:
contacting the hydrophobic phase and the hydrophilic phase of the two-phase oral care whitening composition of claim 1 with one another to form a mixture; and
generating peracetic acid from the mixture.
13. The method of claim 12 , further comprising contacting surfaces of the teeth with the peracetic acid generated from the mixture.
14. The method of claim 12 , wherein contacting the surfaces of the teeth with the peracetic acid generated from the mixture comprises disposing the mixture in a dental tray.
15. The method of claim 14 , wherein contacting the surfaces of the teeth with the peracetic acid generated from the mixture further comprises disposing the dental tray about the teeth to contact the peracetic acid with the surfaces of the teeth.
16. The two-phase oral care whitening composition according to claim 1 , wherein when the hydrophobic phase and the hydrophilic phase are combined the resulting oral care product has a viscosity of from about 100,000 cP to about 150,000 cP.