Hydrophilic copolymer and medical device

1. A medical device comprising:

a substrate layer; and

a surface lubricious layer that is formed on at least a part of a surface of the substrate layer, wherein the surface lubricious layer contains a hydrophilic copolymer comprising:

structural units derived from a polymerizable monomer (A) having a sulfobetaine structure;

structural units derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group (—SO 3 H), a sulfuric acid group (—OSO 3 H), a sulfurous acid group (—OSO 2 H), and groups of salts thereof; and

structural units derived from a polymerizable monomer (C) having a photoreactive group,

wherein the polymerizable monomer (B) is represented by the following formula (2):

wherein

R 21 is a hydrogen atom or a methyl group,

Z 2 is an oxygen atom or —NH—,

R 22 is a straight chain or branched chain alkylene group having 1 to 20 carbon atoms, and

X is a group selected from the group consisting of a sulfonic acid group (—SO 3 H), a sulfuric acid group (—OSO 3 H), a sulfurous acid group (—OSO 2 H), and groups of salts thereof.

2. A medical device comprising:

a substrate layer; and

a surface lubricious layer that is formed on at least a part of a surface of the substrate layer, wherein the surface lubricious layer contains a hydrophilic copolymer comprising:

structural units derived from a polymerizable monomer (A) having a sulfobetaine structure;

structural units derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group (—SO 3 H), a sulfuric acid group (—OSO 3 H), a sulfurous acid group (—OSO 2 H), and groups of salts thereof; and

structural units derived from a polymerizable monomer (C) having a photoreactive group,

wherein the surface lubricious layer is bound to the substrate layer via the photoreactive group of the hydrophilic copolymer.

3. The medical device according to claim 1 , which is a catheter, a stent, or a guide wire.

4. The medical device according to claim 1 , wherein the polymerizable monomer (A) is represented by the following formula (1):

wherein

R 11 is a hydrogen atom or a methyl group,

Z 1 is an oxygen atom or —NH—,

R 12 and R 15 are each independently a straight chain or branched chain alkylene group having 1 to 20 carbon atoms, and

R 13 and R 14 are each independently a straight chain or branched chain alkyl group having 1 to 20 carbon atoms.

5. The medical device according to claim 1 , wherein in formula (1):

Z 1 is an oxygen atom,

R 12 and R 15 are each a straight chain alkylene group having 1 to 3 carbon atoms, and

R 13 and R 14 are each independently a methyl group.

6. The medical device according to claim 1 , wherein the polymerizable monomer (A) includes {2-[(meth)acryloyloxy]ethyl}dimethyl-(3-sulfopropyl)ammonium hydroxide, [3-(methacryloylamino)propyl]dimethyl(3-sulfopropyl)ammonium hydroxide, or a combination thereof.

7. The medical device according to claim 1 , wherein in the formula (2):

Z 2 is —NH—,

R 22 is a branched chain alkylene group having 3 to 5 carbon atoms, and

X is a sulfonic acid group or a group of a salt thereof.

8. The medical device according to claim 1 , wherein the photoreactive group is an azide group, a diazo group, a diazirine group, a ketone group, or a quinone group.

9. The medical device according to claim 1 , wherein the polymerizable monomer (C) includes, in addition to the photoreactive group, an ethylenically unsaturated group.

10. The medical device according to claim 2 , wherein the photoreactive group is an azide group, a diazo group, a diazirine group, a ketone group, or a quinone group.

11. The medical device according to claim 2 , wherein the polymerizable monomer (C) includes, in addition to the photoreactive group, an ethylenically unsaturated group.

12. The medical device according to claim 1 , wherein the surface lubricious layer is bound to the substrate layer via the photoreactive group of the hydrophilic copolymer.