IP Library › Granted Patent US 11,379,983
Granted Patent B2
US 11,379,983 · App. 16/623,003 · Granted Jul 5, 2022

Analysis device, analysis program, and analysis method

Inventors: Takuro Saigo (Tokyo, JP); Shoko Yamasaki (Tokyo, JP); Masayuki Murata (Tokyo, JP); Fumi Kano (Tokyo, JP); Yoshiyuki Noguchi (Tokyo, JP)
Assignees: NIKON CORPORATION; THE UNIVERSITY OF TOKYO
G06T7/0016G01N15/1056G06V20/693G06V20/695G06V20/698G01N2015/1006G06T2207/10056G06T2207/30024
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Quick Facts
Patent No.
US 11,379,983
App. No.
16/623,003
Granted
Jul 5, 2022
Kind
B2
Abstract

An analysis device configured to analyze an attribute of a correlation between responses with respect to a stimulus to a first subcellular component that is a subcellular component of a cell and a second subcellular component different from the first subcellular component, the analysis device including an attribute analysis unit that analyzes the attribute of the correlation between the first subcellular component and the second subcellular component based on a first change in a feature value of the second subcellular component with respect to the stimulus in a state a function of the first subcellular component is suppressed and a second change in a feature value of the second subcellular component with respect to the stimulus in a state the function of the first subcellular component is not suppressed.

Claims (33)

1. An analysis device configured to analyze an attribute of a correlation between responses to a stimulus to a first subcellular component that is a subcellular component of a cell and a second subcellular component different from the first subcellular component, the analysis device comprising:

an attribute analysis unit that analyzes the attribute of the correlation between the first subcellular component and the second subcellular component based on a first change in a feature value of the second subcellular component with respect to the stimulus in a state a function of the first subcellular component is suppressed and a second change in the feature value of the second subcellular component with respect to the stimulus in a state the function of the first subcellular component is not suppressed, wherein

a response time with respect to the stimulus of a third change in a feature value of the first subcellular component with respect to the stimulus is identical to a response time with respect to the stimulus of the second change.

2. The analysis device according to claim 1 , wherein the attribute analysis unit analyzes the attribute of the correlation between the first subcellular component and the second subcellular component based on a difference between the first change and the second change.

3. The analysis device according to claim 1 , wherein

the attribute analysis unit analyzes the attribute of the correlation between the first subcellular component and the second subcellular component based on a difference between a variation of the first change and a variation of the second change.

4. An analysis device configured to analyze an attribute of a correlation between responses to a stimulus to a first subcellular component that is a subcellular component of a cell and a second subcellular component different from the first subcellular component, the analysis device comprising:

an attribute analysis unit that analyzes the attribute of the correlation between the first subcellular component and the second subcellular component based on a first change in a feature value of the second subcellular component with respect to the stimulus in a state a function of the first subcellular component is suppressed and a second change in the feature value of the second subcellular component with respect to the stimulus in a state the function of the first subcellular component is not suppressed, wherein

the attribute of the correlation is analyzed based on strength of a correlation between the feature value of the first subcellular component and the feature value of the second subcellular component.

5. An analysis device configured to analyze an attribute of a correlation between responses to a stimulus to a first subcellular component that is a subcellular component of a cell and a second subcellular component different from the first subcellular component, the analysis device comprising:

an attribute analysis unit that analyzes the attribute of the correlation between the first subcellular component and the second subcellular component based on a first change in a feature value of the second subcellular component with respect to the stimulus in a state a function of the first subcellular component is suppressed and a second change in the feature value of the second subcellular component with respect to the stimulus in a state the function of the first subcellular component is not suppressed, wherein

the attribute of the correlation is at least one of (i) an order of activation of the first subcellular component and the second subcellular component due to the stimulus, (ii) a state of activation of the first subcellular component and the second subcellular component due to the stimulus, and (iii) a causal relationship between the first subcellular component and the second subcellular component with respect to the stimulus.

6. The analysis device of claim 1 , wherein

the first change and the second change are each a change over time in the feature value of the second subcellular component with respect to the stimulus.

7. An analysis device configured to analyze an attribute of a correlation between responses to a stimulus to a first subcellular component that is a subcellular component of a cell and a second subcellular component different from the first subcellular component, the analysis device comprising:

an attribute analysis unit that analyzes the attribute of the correlation between the first subcellular component and the second subcellular component based on a first change in a feature value of the second subcellular component with respect to the stimulus in a state a function of the first subcellular component is suppressed and a second change in the feature value of the second subcellular component with respect to the stimulus in a state the function of the first subcellular component is not suppressed, wherein

the first change is calculated based on comparison of instances of the feature value that change in a time-dependent manner with respect to the stimulus.

8. The analysis device according to claim 7 , wherein

the comparison is performed by comparing the instances of (i) the feature value at a predetermined time and (ii) the feature value at a time different from the predetermined time.

9. The analysis device according to claim 7 , wherein

the comparison is performed by comparing at once the instances of feature values each measured after a different elapse of time.

10. A non-transitory computer readable medium storing thereon an analysis program for causing a computer, provided in an analysis device, to perform an analysis method for analyzing an attribute of a correlation between responses with respect to a stimulus to a first subcellular component that is a subcellular component of a cell and a second subcellular component different from the first subcellular component, the analysis method comprising:

an attribute analysis step of analyzing the attribute of the correlation between the first subcellular component and the second subcellular component based on a first change in a feature value of the second subcellular component with respect to the stimulus in a state a function of the first subcellular component is suppressed and a second change in the feature value of the second subcellular component with respect to the stimulus in a state the function of the first subcellular component is not suppressed, wherein

a response time with respect to the stimulus of a third change in a feature value of the first subcellular component with respect to the stimulus is identical to a response time with respect to the stimulus of the second change.

11. A non-transitory computer readable medium storing thereon an analysis program for causing a computer, provided in an analysis device, to perform an analysis method for analyzing an attribute of a correlation between responses with respect to a stimulus to a first subcellular component that is a subcellular component of a cell and a second subcellular component different from the first subcellular component, the analysis method comprising:

an attribute analysis step of analyzing the attribute of the correlation between the first subcellular component and the second subcellular component based on a first change in a feature value of the second subcellular component with respect to the stimulus in a state a function of the first subcellular component is suppressed and a second change in the feature value of the second subcellular component with respect to the stimulus in a state the function of the first subcellular component is not suppressed, wherein

the attribute of the correlation is analyzed based on strength of a correlation between the feature value of the first subcellular component and the feature value of the second subcellular component.

12. A non-transitory computer readable medium storing thereon an analysis program for causing a computer, provided in an analysis device, to perform an analysis method for analyzing an attribute of a correlation between responses with respect to a stimulus to a first subcellular component that is a subcellular component of a cell and a second subcellular component different from the first subcellular component, the analysis method comprising:

an attribute analysis step of analyzing the attribute of the correlation between the first subcellular component and the second subcellular component based on a first change in a feature value of the second subcellular component with respect to the stimulus in a state a function of the first subcellular component is suppressed and a second change in the feature value of the second subcellular component with respect to the stimulus in a state the function of the first subcellular component is not suppressed, wherein

the attribute of the correlation is at least one of (i) an order of activation of the first subcellular component and the second subcellular component due to the stimulus, (ii) a state of activation of the first subcellular component and the second subcellular component due to the stimulus, and (iii) a causal relationship between the first subcellular component and the second subcellular component with respect to the stimulus.

13. A non-transitory computer readable medium storing thereon an analysis program for causing a computer, provided in an analysis device, to perform an analysis method for analyzing an attribute of a correlation between responses with respect to a stimulus to a first subcellular component that is a subcellular component of a cell and a second subcellular component different from the first subcellular component, the analysis method comprising:

an attribute analysis step of analyzing the attribute of the correlation between the first subcellular component and the second subcellular component based on a first change in a feature value of the second subcellular component with respect to the stimulus in a state a function of the first subcellular component is suppressed and a second change in the feature value of the second subcellular component with respect to the stimulus in a state the function of the first subcellular component is not suppressed, wherein

the first change is calculated based on comparison of instances of the feature value that change in a time-dependent manner with respect to the stimulus.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 23, 2021
From: NIKON CORPORATION
To: UNIVERSITY OF TOKYO
Reel/Frame 057256/0901 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 23, 2021
From: MURATA, MASAYUKI; KANO, FUMI; NOGUCHI, YOSHIYUKI
To: NIKON CORPORATION; THE UNIVERSITY OF TOKYO
Reel/Frame 057257/0221 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 16, 2019
From: SAIGO, TAKURO; YAMASAKI, SHOKO
To: NIKON CORPORATION
Reel/Frame 051288/0949 →
Continuity (1)
Related Publication 20200410682A1 · Dec 31, 2020