Gel for treating periocular and/or orbital pathologies and conditions
A method comprising treating a periocular wound in a subject, comprising topically administering to the periocular wound a composition comprising at least one thermoresponsive gel.
1. A thermoresponsive gel comprising:
a copolymer of (a) N-isopropylacrylamide and (b) at least one acrylic monomer or at least one methacrylic monomer, wherein the acrylic monomer is an alkyl acrylate, a co-poly(ethylene glycol) acrylate, or an acrylated γ-butyrolactone, and the methacrylic monomer is 2-hydroxymethacrylate, butyl methacrylate, methyl ether methacrylate, methyl methacrylate, or co-poly(ethylene glycol) methacrylate; and
at least one additional additive selected from a poly(siloxane), a bisacrylamide, a dimethacrylate, chitosan, a chitosan derivative, an alginate, an acrylated polysaccharide, hyaluronan, or a combination thereof.
2. The thermoresponsive gel of claim 1 , wherein the alkyl acrylate is methyl acrylate, ethyl acrylate, butyl acrylate or 2-ethylhexyl acrylate.
3. The thermoresponsive gel of claim 1 , wherein the methacrylic monomer is hydroxyethyl methacrylate, butyl methacrylate, methyl ether methacrylate or methyl methacrylate.
4. The thermoresponsive gel of claim 1 , wherein the acrylic monomer is a co-poly(ethylene glycol) acrylate or the methacrylate monomer is a co-poly(ethylene glycol) methacrylate.
5. The thermoresponsive gel of claim 1 , wherein the acrylic monomer is an acrylated γ-butyrolactone.
6. The thermoresponsive gel of claim 1 , wherein the additional additive is selected from chitosan, a chitosan derivative, an alginate, or a combination thereof.
7. The thermoresponsive gel of claim 1 , further comprising dexamethasone.
8. The thermoresponsive gel of claim 1 , wherein the copolymer is poly(N-isopropylacrylamide-co-ethyl acrylate) copolymer.
9. The thermoresponsive gel of claim 1 , further comprising a therapeutic agent.
10. The thermoresponsive gel of claim 8 , wherein the additional additive is an alginate and further comprising a corticosteroid.
11. The thermoresponsive gel of claim 1 , wherein the additional additive is an acrylated poly(dimethylsiloxane).
12. The thermoresponsive gel of claim 1 , wherein the additional additive is chitosan or a chitosan salt, and wherein the copolymer is present in an amount of 50% to 90% (w/w), and the chitosan or a chitosan salt is present in an amount of 50 to 10% (w/w).
13. The thermoresponsive gel of claim 1 , wherein the additional additive is sodium alginate crosslinked with a divalent salt.
14. The thermoresponsive gel of claim 6 , wherein the copolymer is poly(N-isopropylacrylamide-co-ethyl acrylate) copolymer.
15. A thermoresponsive gel comprising:
a copolymer of (a) N-isopropylacrylamide and (b) at least one acrylic monomer or at least one methacrylic monomer, wherein the acrylic monomer is a co-poly(ethylene glycol) acrylate or an acrylated γ-butyrolactone, or the methacrylate monomer is a co-poly(ethylene glycol) methacrylate; and
at least one additional additive selected from a poly(siloxane), a bisacrylamide, a dimethacrylate, a polysaccharide, or a combination thereof.
16. The thermoresponsive gel of claim 15 , further comprising a therapeutic agent.
17. The thermoresponsive gel of claim 15 , wherein the additional additive is selected from chitosan, a chitosan derivative, an alginate, or a combination thereof.