Nicotine ion pair formulation neutralized with CO2 and process therefor
Nicotine ion pair formulations neutralized with CO 2 are disclosed herein. The nicotine ion pair formulations have the general formula C 10 H 14 N 2 H + CO 2 Sol − , wherein C 10 H 14 N 2 is nicotine and Sol is a solvent. A process of preparing the nicotine ion pair formulations neutralized with CO 2 . is also disclosed herein. An e-liquid comprising a nicotine ion pair formulation neutralized with CO 2 and the use of the e-liquid in a vaporization device are further disclosed herein. Finally, a vaporization device charged with an e-liquid comprising a nicotine ion pair formulation neutralized with CO 2 is disclosed herein.
1. A CO 2 -nicotine ion pair formulation of formula:
C 10 H 14 N 2 H + CO 2 Sol −
wherein C 10 H 14 N 2 is nicotine and Sol is a polar protic solvent.
2. The CO 2 -nicotine ion pair formulation of claim 1 , having the formula:
C 10 H 14 N 2 H + CO 2 C 3 H 7 O 2 −
wherein C 10 H 14 N 2 is nicotine and C 3 H 7 O 2 − is propylene glycoxide.
3. The CO 2 -nicotine ion pair formulation according to claim 1 , further comprising an organic acid.
4. The CO 2 -nicotine ion pair formulation according to claim 3 , wherein the organic acid is at least one of a monocarboxylic acid, a dicarboxylic acid, a polycarboxylic acid, an aromatic acid, a nitroaromatic acid, or a combination of any thereof.
5. The CO 2 -nicotine ion pair formulation of claim 3 , wherein the organic acid is glycolic acid.
6. The CO 2 -nicotine ion pair formulation according to claim 1 , further comprising a carrier.
7. The CO 2 -nicotine ion pair formulation of claim 6 , wherein the carrier comprises at least one of propylene glycol or vegetable glycerin.
8. The CO 2 -nicotine ion pair formulation according to claim 1 , further comprising a flavoring agent.
9. A process of preparing a CO 2 -nicotine ion pair formulation, the process comprising neutralizing nicotine with CO 2 , wherein the nicotine is solvated in a polar protic solvent.
10. The process according to claim 9 , further comprising neutralizing the nicotine with an organic acid.
11. The process according to claim 10 , wherein the organic acid is at least one of a monocarboxylic acid, a dicarboxylic acid, a polycarboxylic acid, an aromatic acid, a nitroaromatic acid, or a combination of any thereof.
12. The process according to claim 10 , wherein the organic acid is glycolic acid.
13. The process according to claim 9 , wherein the solvent comprises propylene glycol.
14. An e-liquid comprising a CO 2 -nicotine ion pair formulation of formula:
C 10 H 14 N 2 H + CO 2 Sol −
wherein C 10 H 14 N 2 is nicotine and Sol is a polar protic solvent.
15. The e-liquid of claim 14 , wherein the CO 2 -nicotine ion pair formulation has the formula:
C 10 H 14 N 2 H + CO 2 C 3 H 7 O 2 −
wherein C 10 H 14 N 2 is nicotine and C 3 H 7 O 2 − is propylene glycoxide.
16. The e-liquid of claim 14 wherein the CO 2 -nicotine ion pair formulation further comprises an organic acid.
17. The e-liquid of claim 16 , wherein the organic acid is at least one of a monocarboxylic acid, a dicarboxylic acid, a polycarboxylic acid, an aromatic acid, a nitroaromatic acid, or a combination of any thereof.
18. A vaporization device comprising the e-liquid of claim 14 .