Non-invasive photonic sensing for monitoring diabetes
The present disclosure relates to a device ( 100 ) for monitoring a biomarker in an exhaled breath, the device ( 100 ) utilising a combination of a sensing element ( 110 ) having a thermochemical reactant ( 120 ) that undergoes a thermochemical reaction with the biomarker and a thermal sensor ( 140 ) positioned to measure a rate of change in temperature caused by the thermochemical reaction. A user interface ( 170 ) is provided for indicating to a user an indicated measure of the biomarker in the exhaled breath, wherein the indicated measure of the biomarker in the exhaled breath is determined from the measured rate of change in temperature.
1. A device for monitoring a biomarker in an exhaled breath, the device comprising:
a sensing element comprising:
a thermochemical reactant that undergoes a thermochemical reaction with the biomarker, and
a sensitivity booster in contact with the thermochemical reactant, wherein the sensitivity booster undergoes a second thermochemical reaction with a product of the reaction between the thermochemical reactant and the biomarker;
a thermal sensor positioned to measure a rate of change in temperature caused by the thermochemical reaction; and
a user interface for indicating to a user an indicated measure of the biomarker in the exhaled breath, wherein the indicated measure of the biomarker in the exhaled breath is determined from the measured rate of change in temperature;
wherein:
the biomarker is a ketone;
the thermochemical reactant is selected from the group consisting of hydroxylamine hydrochloride and O-benzylhydroxylamine hydrochloride; and
the sensitivity booster comprises a metal.
2. The device according to claim 1 , wherein the sensitivity booster is at least one layer on the thermochemical reactant.
3. The device according to claim 1 , wherein the sensitivity booster is dispersed in the thermochemical reactant.
4. The device according to claim 1 , wherein the sensing element comprises a support element for supporting the thermochemical reactant.
5. The device according to claim 1 , wherein the sensing element is mounted in a housing, the housing comprising an inlet for receiving the exhaled breath.
6. The device according to claim 5 , wherein the sensing element is removably mounted in the housing.
7. The device according to claim 1 , wherein the device is configured to receive a predetermined volume of the exhaled breath.
8. The device according to claim 1 , further comprising a flow meter for measuring a flow rate of the exhaled breath into the device.
9. The device according to claim 1 , wherein the biomarker is acetone.
10. The device according to claim 9 , wherein the thermochemical reactant is hydroxylamine hydrochloride.
11. The device according to claim 9 , wherein the sensitivity booster is aluminium.
12. The device according to claim 1 , further comprising processing means for receiving data describing the measured rate of change in temperature and determining from the data the measure of the biomarker in the exhaled breath.
13. The device according to claim 12 , wherein the processing means communicates a determined measure of the biomarker in the exhaled breath to the user interface.
14. The device according to claim 1 , wherein the thermal sensor comprises a temperature dependant colour change material, and wherein the indicated measure of the biomarker in the exhaled breath is based on the colour of the material a predetermined period of time after the exhaled breath is introduced to the device.
15. The device according to claim 1 , wherein the device is configured to receive the exhaled breath from a subject's mouth.
16. The device according to claim 1 , wherein the device is configured to receive the exhaled breath from a subject's nose.
17. The device according to claim 1 , further comprising a reference thermal sensor positioned to measure background temperatures in the device.
18. A method of monitoring a biomarker in an exhaled breath comprising:
contacting the exhaled breath with a sensing element, the sensing element comprising:
a thermochemical reactant that undergoes a thermochemical reaction with the biomarker, and
a sensitivity booster in contact with the thermochemical reactant, wherein the sensitivity booster undergoes a second thermochemical reaction with a product of the reaction between the thermochemical reactant and the biomarker;
measuring with a thermal sensor a rate of change in temperature caused by the thermochemical reaction; and
determining from a measured rate of change in temperature a measure of the biomarker in the exhaled breath;
wherein:
the biomarker is a ketone;
the thermochemical reactant is selected from the group consisting of hydroxylamine hydrochloride and O-benzylhydroxylamine hydrochloride; and the sensitivity booster comprises a metal.