IP Library › Granted Patent US 11,406,321
Granted Patent B2
US 11,406,321 · App. 16/629,249 · Granted Aug 9, 2022

Wearable fluidic system for measuring sweat composition

Inventors: Jeffrey B. Model (Cambridge, MA); Roozbeh Ghaffari (Cambridge, MA); Alexander J. Aranyosi (Cambridge, MA); Stephen P. Lee (Cambridge, MA); Milan S. Raj (Cambridge, MA)
Assignee: Epicore Biosystems, Inc.
A61B5/4266A61B5/002A61B5/0077A61B5/02055A61B5/1034A61B5/14517A61B5/14532A61B5/14539A61B5/14546A61B5/6833A61B5/746G16H20/00A61B5/024A61B10/0064A61B2562/164
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Quick Facts
Patent No.
US 11,406,321
App. No.
16/629,249
Granted
Aug 9, 2022
Kind
B2
Abstract

A sweat sensing device includes a flexible body having a first, outwardly facing surface and a second, skin facing surface and a sweat channel formed in the body, the sweat channel having a first end defining a fluid inlet and a second end. A biochemical assay well formed in the sweat channel and an assay material is disposed in the biochemical assay well, the assay material positioned to react with sweat traveling through the sweat channel and to provide one of a visual indicator and an indicator detectable by a camera and connected processor of the flow of the sweat in the sweat channel.

Claims (28)

1. A sweat sensing device comprising:

a flexible body having a first, outwardly facing surface and a second, skin facing surface;

a first sweat channel formed in the body, the first sweat channel having a first end defining a fluid inlet and a second end, and a biochemical assay well formed in the first sweat channel;

an assay material disposed in the biochemical assay well of the first sweat channel, the assay material positioned to react with sweat traveling through the sweat channel and to provide one of a visual indicator and an indicator detectable by a camera and connected processor of the flow of the sweat in the sweat channel; and

a second sweat channel formed in the body, the second sweat channel including a first end defining a fluid inlet and a second end, a color viewing window formed in the second sweat channel, and a biochemical assay well formed in the second sweat channel between the first end and the color viewing window;

wherein the biochemical assay well of the second sweat channel defines a chloranilate mixing well, the sweat sensing device further including chloranilate disposed in the biochemical assay well, and wherein the chloranilate is suspended in a suspension of one of p-HEMA and polyethylene glycol, the color viewing window positioned to collect sweat that has passed through and reacted with the chloranilate in the biochemical assay well, and to provide one of a visual indicator and an indicator detectable by a camera and connected processor of a color of the sweat and chloranilate in the color viewing window.

2. The sweat sensing device according to claim 1 , wherein the flexible body is formed from three layers of material bonded together, and wherein the sweat channel is formed in an inner layer of the three layers.

3. The sweat sensing device according to claim 1 , wherein the flexible body is formed from five layers of material bonded together, and wherein the sweat channel is formed in one of one of three inner layers of the five layers and a plurality of any of the three inner layers of the five layers.

4. The sweat sensing device according to claim 1 , wherein the second end of the sweat channel defines a fluid outlet.

5. The sweat sensing device according to claim 1 , including a plurality of the second sweat channels, each of the plurality of second sweat channels having a different assay material disposed in its biochemical assay well.

6. The sweat sensing device according to claim 5 , wherein the assay materials are chosen to detect one of physiologic and a biometric condition in the sweat in the second sweat channel, the physiologic and a biometric conditions selected from the group consisting of sweat volume, sweat volume loss, sweat rate, sweat chloride loss, sweat sodium loss, sweat lactate loss, sweat electrolyte loss, sweat metabolite loss, sweat pH, sweat glucose, and foreign chemical and toxin concentrations in the sweat.

7. A sweat monitoring system comprising:

a sweat sensing device configured to be adhered to the skin of a user to collect sweat and detect one of physiologic and a biometric condition selected from the group consisting of sweat volume, sweat volume loss, sweat rate, sweat chloride loss, sweat sodium loss, sweat lactate loss, sweat electrolyte loss, sweat metabolite loss, sweat pH, sweat glucose, and foreign chemical and toxin concentrations in the sweat;

an interactive console station having a connected camera;

wherein the camera of the interactive console station captures an image of the sweat sensing device and generates an output to the user via the interactive console station;

a smartphone having a camera, wherein the smartphone camera captures an image of the sweat sensing device and generates an output to the user via one of the interactive console station and the smartphone display screen;

wherein the image of the sweat sensing device is captured a plurality of times while the sweat sensing device is being worn and adhered to the skin of the user;

wherein a processor in one of the interactive console station and the smartphone uses one or more algorithms to generate the output;

wherein the output is one of a recommendation of a specific formulation of electrolytes, carbohydrates, and fluids to consume to achieve electrolyte and metabolite balance in the user, a recommendation to consume specific nutrients, a recommendation to alter a temperature, a recommendation to alter a level of exertion, an alert to a caregiver, and alert to emergency personnel, a signal that causes the room temperature to change to mitigate risks of one of dehydration and heat injury, a signal that activates a weighing station to measure one of heart rate and body temperature, and a signal that one of dims the lights and turns on a motorized fan in the user's environment;

wherein the output and recommendations communicated to the user via one of the smartphone and the interactive console station;

wherein the sweat sensing device includes a flexible body formed from five layers of material bonded together and having:

a first, outwardly facing surface;

a second, skin facing surface;

a first sweat channel formed in the body, the first sweat channel having a first end defining a fluid inlet and a second end, wherein the first sweat channel is formed in one of one of three inner layers of the five layers and a plurality of any of the three inner layers of the five layers, a biochemical assay well formed in the first sweat channel, and an assay material disposed in the biochemical assay well, the assay material positioned to react with sweat traveling through the sweat channel and to provide one of a visual indicator and an indicator detectable by a camera and connected processor of the flow of the sweat in the sweat channel; and

a second sweat channel formed in the body, the second sweat channel having a first end defining a fluid inlet and a second end, a color viewing window formed in the second sweat channel, a biochemical assay well formed in the second sweat channel between the first end and the color viewing window, and chloranilate disposed in the biochemical assay well, wherein the chloranilate is suspended in a suspension of one of p-HEMA and polyethylene glycol, and wherein the color viewing window is positioned to collect sweat that has passed through and reacted with the chloranilate in the biochemical assay well, and to provide one of a visual indicator and an indicator detectable by a camera and connected processor of a color of the sweat and chloranilate in the color viewing window.

8. The sweat monitoring system according to claim 7 , wherein the sweat monitoring system includes a plurality of the sweat sensing devices configured to be adhered to the skin of a user to collect sweat and detect one of the physiologic and a biometric conditions.

9. The sweat monitoring system according to claim 7 , including a plurality of the second sweat channels, each of the plurality of second sweat channels having a different assay material disposed in its biochemical assay well;

wherein the assay materials are chosen to detect one of physiologic and a biometric condition in the sweat in the second sweat channel, the physiologic and a biometric conditions selected from the group consisting of sweat volume, sweat volume loss, sweat rate, sweat chloride loss, sweat sodium loss, sweat lactate loss, sweat electrolyte loss, sweat metabolite loss, sweat pH, sweat glucose, and foreign chemical and toxin concentrations in the sweat.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 16, 2020
From: MODEL, JEFFREY B.; GHAFFARI, ROOZBEH; ARANYOSI, ALEXANDER J.; LEE, STEPHEN P.; RAJ, MILAN S.
To: EPICORE BIOSYSTEMS, INC.
Reel/Frame 051534/0992 →
Continuity (2)
Provisional Application 62536462 · Jul 25, 2017
Related Publication 20200129112A1 · Apr 30, 2020
Cited By (1)
US 12,376,836