Dosing schedule of a Wnt inhibitor and an anti-PD-1 antibody molecule in combination
The present disclosure relates to the field of pharmacy, particularly to a Wnt inhibitor and a PD-1 inhibitor for use in the treatment of cancer. Specifically, the disclosure relates to a pharmaceutical combination comprising a Wnt inhibitor, or a pharmaceutically acceptable salt thereof, and a PD-1 inhibitor, or a pharmaceutically acceptable salt thereof, for use in the treatment of cancer, to a method for the treatment of cancer that involves administering the combination and to the use of the combination for the manufacture of a medicament for the treatment of cancer.
1. A method of treating cancer comprising the administration of a pharmaceutical combination comprising (i) 2-(2′,3-dimethyl-[2,4′-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide, or a pharmaceutically acceptable salt thereof, and (ii) anti-PD-1 antibody molecule or a pharmaceutically acceptable salt thereof, wherein (a) (i) is administered daily on days 1 to 15, or days 1 to 16, of each cycle for up to 4 cycles, or (b) (i) is administered daily during days 1 to 8 of each cycle for up to 4 cycles, (ii) is administered at least once per cycle, and wherein each cycle is 28 days or 30 days.
2. The method of treating cancer according to claim 1 , wherein (i) is administered during the first cycle only or wherein (i) is administered during 4 cycles only.
3. The method of treating cancer according to claim 1 , wherein each cycle is 28 days.
4. The method of treating cancer according to claim 1 , wherein (i) is administered twice daily.
5. The method of treating cancer according to claim 4 , wherein (i) is administered at 12-hour intervals.
6. The method of treating cancer according to claim 1 , wherein the daily dose of (i) is 2.5 mg/day, 5 mg/day, 7.5 mg/day, 10 mg/day, 20 mg/day, 40 mg/day, 80 mg/day, 120 mg/day, or 180 mg/day.
7. The method of treating cancer according to claim 6 , wherein the daily dose of (i) is 2.5 mg/day, 5 mg/day, or 10 mg/day.
8. The method of treating cancer according to claim 7 , wherein the daily dose of (i) is 10 mg/day.
9. The method of treating cancer according to claim 1 , wherein (ii) is administered every 2 weeks or every 4 weeks in a cycle.
10. The method of treating cancer according to claim 9 , wherein (ii) is administered, every 4 weeks.
11. The method of treating cancer according to claim 1 , wherein (ii) is PDR-001, or a pharmaceutical salt thereof.
12. The method of treating cancer according to claim 11 , wherein (ii) is administered intravenously in a single dose of 300 to 400 mg/day.
13. The method of treating cancer according to claim 12 , wherein the single dose is 400 mg/day.
14. The method of treating cancer according to claim 1 , wherein (a) 2.5 mg/day of (i) is administered on days 1-8 or (b) 2.5 mg/day of (i) is administered on days 1-15; and 400 mg/day of (ii) is administered once every 4 weeks for up to 4 cycles.
15. The method of treating cancer according to claim 14 , wherein 2.5 mg/day of (i) is administered during cycle 1 only and 400 mg/day of (ii) is administered every 4 weeks.
16. The method of treating cancer according to claim 1 , wherein (a) 5 mg/day of (i) is administered on days 1-8, or (b) 5 mg/day of (i) is administered on days 1-15; and 400 mg/day of (ii) is administered once every 4 weeks for up to 4 cycles.
17. The method of treating cancer according to claim 16 , wherein 5 mg/day of (i) is administered during cycle 1 only and 400 mg/day of (ii) is administered every 4 weeks.
18. The method of treating cancer according to claim 1 , wherein (a) 10 mg/day of (i) is administered daily on days 1-8 or (b) 10 mg/day of (i) is administered on days 1-15; and 400 mg/day of (ii) is administered every 4 weeks for up to 4 cycles.
19. The method of treating cancer according to claim 18 , wherein 10 mg/day of (i) is administered during cycle 1 only and 400 mg/day of (ii) is administered every 4 weeks.
20. The method of treating cancer according to claim 1 , wherein (ii) is administered continuously every 4 weeks.
21. The method for the treatment of cancer according to claim 1 wherein the cancer is triple-negative breast cancer (TNBC), head and neck squamous cell carcinoma, pancreatic cancer, gastrointestinal cancer, colorectal cancer, squamous cell cancer of the lung, squamous cell cancer of the esophagus, squamous cell cancer of the cervix or melanoma.
22. The method for the treatment of cancer according to claim 21 , wherein the cancer is triple-negative breast cancer (TNBC), pancreatic cancer or melanoma.
23. The method for the treatment of cancer according to claim 1 , wherein (i) and (ii) are synergistically active at reducing bone resorption.
24. The method for the treatment of cancer according to claim 1 , wherein (i) 2-(2′,3-dimethyl-[2,4′-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide, or a pharmaceutically acceptable salt thereof, is administered orally or intravenously.