Membrane lipid coated viral nanoparticles and method of use
Disclosed is a nanoparticle comprising an inner core comprising a virus; and an outer surface comprising a cellular membrane derived from a cell, and process of making thereof. The virus is an oncolytic virus and cellular membrane is derived from for example red blood cells.
1. A process of making a nanoparticle comprising combining an inner core comprising a single virus, and an outer surface comprising a cellular membrane derived from a blood cell, an adipocyte, a stem cell, an endothelial cell, an exosome, a secretory vesicle or a synaptic vesicle in a non-salt water solution; applying sonication to said mixture to form a nanoparticle comprising said inner core coated with said outer surface.
2. The process of claim 1 , where said non-salt water solution is a sugar solution.
3. The process of claim 2 , wherein said sugar solution is sucrose, or dextrose containing solution.
4. The process of claim 1 wherein said virus is an oncolytic virus.
5. The process of claim 4 , wherein said oncolytic virus is herpesvirus; vaccinia virus; reovirus; adenovirus; measles virus, parvovirus, or combinations thereof.
6. The process of claim 4 wherein said virus is adenovirus.
7. The process of claim 1 wherein said blood cell is red blood cell, white blood cell, or platelet.
8. The process of claim 1 wherein said blood cell is red blood cell.