Multifunctional cytoprotectant for treatment of pathogenic processes mediated by oxidative stress and toxic electrophiles
Methods, filters and compositions are disclosed for treating toxicity due to oxidative stress and toxic electrophiles.
1. A compound having the structure:
wherein R 1 is alkyl, cycloalkyl, or
R 2 is NH 2 , NHCOR 3 , NH-alkyl, SH, S-alkyl, or S-aryl, or
wherein R 3 is hydrogen or alkyl;
or a tautomer, a geometric isomer, an optical isomer, a racemate, or a pharmaceutically acceptable salt thereof.
2. A pharmacological composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.
3. A formulation of a compound of claim 1 , wherein the compound is present in an amount effective to increase the viability of an organ for transplantation.
4. A composition comprising a compound of claim 1 for treating toxicity associated with a therapeutic agent, wherein the composition comprises a therapeutically effective amount of the compound.
5. A filter comprising a compound of claim 1 for reducing toxicity associated with an environmental agent or toxin, wherein the filter comprises a therapeutically effective amount of the compound.
6. The compound of claim 1 , wherein any alkyl is independently C1-C6 alkyl.
7. The compound of claim 1 , wherein any alkyl is independently C1-C3 alkyl.
8. A compound having the structure:
or a tautomer; a geometric isomer, an optical isomer; a racemate, or a pharmaceutically acceptable salt thereof.
9. The compound of claim 1 , wherein the cycloalkyl is independently substituted with one or more of ═O, OH, halogen, CH 3 or NH 2 .
10. The compound of claim 1 , wherein any alkyl is a branched alkyl or an unbranched alkyl.