Prophylactic or therapeutic agent for pulmonary hypertension comprising unsaturated 5-membered heterocycle-containing compound
The present invention provides a preventive or therapeutic agent for pulmonary hypertension, including a compound represented by the following formula (I) or a salt thereof: where: —A— represents —NH—, —S—, or —O—; R 1 and R 2 are identical to or different from each other, and each represent a hydrogen atom or an alkyl group; R 3 represents a hydrogen atom, a halogen atom, or an alkyl group; R 4 represents a hydrogen atom or an alkyl group; R 5 represents a hydrogen atom or an alkyl group; R 6 and R 7 are identical to or different each other, and each represent a hydrogen atom, a halogen atom, or an alkyl group; and R 6 and R 7 may form an unsaturated hydrocarbon six-membered ring together with a carbon atom to which R 6 is bonded and a carbon atom to which R 7 is bonded.
1. A method of preventing or treating pulmonary hypertension, comprising administering an effective dose of a compound represented by the following formula (I) or a salt thereof to a patient in need of the prevention or treatment of pulmonary hypertension:
where: —A— represents —NH—, —S—, or —O—; R 1 and R 2 are identical to or different from each other, and each represent a hydrogen atom or an alkyl group; R 3 represents a hydrogen atom, a halogen atom, or an alkyl group; R 4 represents a hydrogen atom or an alkyl group; R 5 represents a hydrogen atom or an alkyl group; R 6 and R 7 are identical to or different from each other, and each represent a hydrogen atom, a halogen atom, or an alkyl group; and R 6 and R 7 may form an unsaturated hydrocarbon six-membered ring together with a carbon atom to which R 6 is bonded and a carbon atom to which R 7 is bonded.
2. The method according to claim 1 , wherein —A— represents —NH—.
3. The method according to claim 1 , wherein R 1 and R 4 both represent hydrogen atoms.
4. The method according to claim 1 , wherein R 5 represents a hydrogen atom.
5. The method according to claim 1 , wherein R 6 and R 7 each represent a hydrogen atom or a halogen atom, and at least one thereof represents a halogen atom.
6. The method according to claim 1 , wherein R 3 represents a halogen atom or an alkyl group.
7. The method according to claim 1 , wherein R 2 represents a hydrogen atom or an alkyl group.
8. The method according to claim 1 ,
wherein —A— represents —NH—,
wherein R 1 , R 4 , and R 5 all represent hydrogen atoms,
wherein R 2 represents a hydrogen atom or an alkyl group,
wherein R 3 represents a halogen atom or an alkyl group, and
wherein R 6 and R 7 each represent a hydrogen atom or a halogen atom, and at least one thereof represents a halogen atom.
9. The method according to claim 1 , wherein R 2 represents a linear alkyl group having 4 or more carbon atoms.
10. The method according to claim 1 , wherein R 2 represents a linear alkyl group having 7 or more carbon atoms.
11. The method according to claim 1 , wherein the patient has pulmonary hypertension.
12. A method of preventing or treating pulmonary hypertension, comprising orally administering an effective dose of a compound represented by the following formula (I) or a salt thereof:
where: —A— represents —NH—, —S—, or —O—; R 1 and R 2 are identical to or different from each other, and each represent a hydrogen atom or an alkyl group; R 3 represents a hydrogen atom, a halogen atom, or an alkyl group; R 4 represents a hydrogen atom or an alkyl group; R 5 represents a hydrogen atom or an alkyl group; R 6 and R 7 are identical to or different from each other, and each represent a hydrogen atom, a halogen atom, or an alkyl group; and R 6 and R 7 may form an unsaturated hydrocarbon six-membered ring together with a carbon atom to which R 6 is bonded and a carbon atom to which R 7 is bonded.