Cryogenic, kinetically active formulations and systems for their dispensing
A cryogenic, kinetically active formulation in a pressurized package; the package; and a method of making the formulation and the package.
1. A cryogenic, kinetically active formulation expelled from a pressurized package, the formulation comprises one or more active agents, which one or more active agents in the formulation is mixed at high speed under controlled temperature and pressure with one or more liquid refrigerants prior to being filled under pressure into said package and expelled from said package;
wherein said one or more liquid refrigerants are added in sufficient amounts to be dispersed in the formulation;
wherein said pressurized package is under sufficient pressure suitable to maintain the one or more liquid refrigerants dispersed in the formulation; and wherein said pressurized package is under sufficient pressure to expel said formulation as a foamlike, cryogenic, kinetically active formulation upon application of external force on said formulation in said package; wherein said one or more liquid refrigerants are non-flammable liquid refrigerants, wherein the one or more non-flammable liquid refrigerants comprise 1,1,1,3,3-Pentafluoropropane (Honeywell HFC-245FA), and either or both trans-1,3,3,3-Tetrafluoroprop-1-ene (Honeywell Solstice 1234ZE), 1-Chloro-3,3,3-trifluoropropene (Honeywell Solstice 1233ZD), wherein the one or more non-flammable liquid refrigerants are about 40% of the formulation.
2. The formulation of claim 1 , wherein at least some of the refrigerants are liquid and the liquid refrigerants are solubilized in the formulation and small micro-pockets of liquid propellants are captured in the formulation.
3. The formulation of claim 1 , wherein said formulation is for topical application.
4. The formulation of claim 1 , wherein the one or more active agents are pain reduction products or skin tighteners.
5. The formulation of claim 1 , wherein the package does not need to be shaken vigorously or at all to expel said formulation as a foamlike, cryogenic, kinetically active formulation upon application of external force on said formulation in said package.
6. The formulation of claim 1 , wherein said package is a bag on valve (BOV) pressurized assembly, comprising a two-way fill/dispensing valve, an attached internal high barrier bag affixed to said valve, and rigid container adapted to holding positive pressure affixed to the valve.
7. The formulation of claim 6 , wherein said container is glass, barrier resin, metal/alloy, or another material capable of holding positive pressure.
8. The formulation of claim 6 , wherein the BOV pressurized assembly expels the formulation in a metered dispensing system.