IP Library › Granted Patent US 11,472,705
Granted Patent B2
US 11,472,705 · App. 16/352,741 · Granted Oct 18, 2022

Nitric oxide releasing compositions

Inventors: Gilly Regev (Vancouver, CA); Christopher C. Miller (North Vancouver, CA)
Assignee: SaNOtize Research and Development Corp.
C01B21/24A61K47/02A61K47/12C01P2006/12C01P2006/14
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Quick Facts
Patent No.
US 11,472,705
App. No.
16/352,741
Granted
Oct 18, 2022
Kind
B2
Abstract

Nitric oxide (NO) generating compositions can include a nitrite component, an acidifying component, and a support material configured to carry one of the nitrite component and the acidifying agent. In some examples, the support material can minimize NO generation prior to addition of an activating amount of a suitable solvent.

Claims (11)

1. A particulate composition, comprising: a blend of a nitrite component and an acidifying agent, wherein the acidifying agent is carried by a calcined support material, and the nitrite component is not carried by a support material.

2. The particulate composition of claim 1 , wherein the nitrite component comprises sodium nitrite, potassium nitrite, barium nitrite, calcium nitrite, nitrite orotate, amyl nitrite, magnesium nitrite, or a combination thereof.

3. The particulate composition of claim 1 , wherein the acidifying agent comprises ascorbic acid, ascorbyl palmitate, salicylic acid, malic acid, lactic acid, citric acid, formic acid, benzoic acid, tartaric acid, hydrochloric acid, sulfuric acid, phosphoric acid, or a combination thereof.

4. The particulate composition of claim 1 , wherein the support material comprises carbon black, activated carbon, a metal oxide, a silica, a silicate, a metal phosphate, or a combination thereof.

5. The particulate composition of claim 1 , wherein the support material has a surface area of at least 0.1 meters squared per gram (m 2 /g).

6. The particulate composition of claim 1 , wherein the support material has a pore volume of at least 0.01 cubic centimeters per gram (cc/g).

7. The particulate composition of claim 1 , wherein the nitrite component and the acidifying agent are present in the particulate composition at a weight ratio of from about 1:2 to about 2:1.

8. The particulate composition of claim 1 , wherein the support material is present in the particulate composition at a weight ratio of from about 0.05:1 to about 10:1 with the nitrite component or the acidifying agent.

9. The particulate composition of claim 1 , wherein the nitrite component is present in the particulate composition in an amount of from about 0.05 wt % to about 99.5 wt %.

10. The particulate composition of claim 1 , wherein the acidifying agent is present in the particulate composition in an amount of from about 0.05 wt % to about 99.5 wt %.

11. The particulate composition of claim 1 , wherein the support material is present in the particulate composition in an amount of from about 0.05 wt % to about 99.5 wt %.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 4, 2020
From: REGEV, GILLY; MILLER, CHRISTOPHER C.
To: SANOTIZE RESEARCH AND DEVELOPMENT CORP.
Reel/Frame 051715/0504 →
Continuity (2)
Provisional Application 62642536 · Mar 13, 2018
Related Publication 20190367366A1 · Dec 5, 2019
Cited By (1)
US 12,252,398