SSAO inhibitors and use thereof

1. A compound of Formula (Ia) or (Ib):

or a pharmaceutically acceptable salt, solvate, stereoisomer, or tautomer thereof, wherein:

each X is independently Cl or F;

p is 0, 1, 2, or 3;

L is absent, —O—, (C 1 -C 4 ) alkylene, substituted (C 1 -C 4 ) alkylene, —O—(C 1 -C 4 ) alkylene, substituted —O—(C 1 -C 4 ) alkylene, (C 1 -C 4 ) alkylene-O—, or substituted (C 1 -C 4 ) alkylene-O—, wherein the substituted (C 1 -C 4 ) alkylene, substituted —O—(C 1 -C 4 ) alkylene, or substituted (C 1 -C 4 ) alkylene-O— is substituted with one or more L 1 ;

each L 1 is independently (C 1 -C 4 ) alkyl, F, or CF 3 ; or two L 1 , together with the atom to which they are attached, form a 3- to 5-membered cycloalkyl ring;

each R 1 is independently H, F, methyl, ethyl, or CF 3 ;

A 1 is CR 5′ ;

R 5′ is H, (C 1 -C 4 ) alkyl, (C 1 -C 4 ) alkoxy, hydroxy, or cyano;

A 2 and A 2′ are each independently absent, CH 2 , CHR 5 , C(R 5 ) 2 , NH, NR 5 , or O, provided that at least one of A 2 and A 2′ is not absent and that A 2 -A 2′ is not O—O, O—NH, O—NR 5 , NH—O, NH—NH, NH—NR 5 , NR 5 —O, NR 5 —NH, or NR 5 —NR 5 ;

A 3 is CH 2 , CHR 5 , C(R 5 ) 2 , NH, NR 5 , or O when m is 0, or CH or CR 5 when m is 1 or 2, provided that A 2 -A 3 is not O—O, O—NH, O—NR 5 , NH—O, NH—NH, NH—NR 5 , NR 5 —O, NR 5 —NH, or NR 5 —NR 5 ;

m is 0, 1, or 2;

n is 1 or 2;

R 2′ is

(C 1 -C 4 ) alkyl substituted with one or more (C 1 -C 4 ) alkoxy,

(C 1 -C 4 ) alkoxy, NR 3 C(O)R 4 , C(O)NR 3 R 4 , or

heterocyclyl comprising one or two 3- to 6-membering rings and 1 to 3 heteroatoms selected from N and O, wherein the heterocyclyl is optionally substituted with one or more R 5 ;

R 3 is H, methyl, or ethyl;

R 4 is (C 1 -C 4 ) alkyl or (C 3 -C 10 ) cycloalkyl optionally substituted with one or more R 8 ; or

R 3 and R 4 , together with atom(s) to which they are attached, form a 3- to 6-membered ring optionally comprising one additional heteroatom selected from N and O and optionally substituted with one or more R 5 ;

each R 5 is independently (C 1 -C 4 ) alkyl, (C 1 -C 4 ) alkoxy, hydroxy, cyano, oxo, C(O)R 7 , C(O)NR 7 R 7′ , NR 3 C(O)R 7 , NR 3 S(O) 2 R 4 , S(O) 2 R 4 , (C 1 -C 4 ) alkyl substituted with one or more hydroxy or R 6 , (C 3 -C 10 ) cycloalkyl optionally substituted with one or more hydroxy or R 6 , or heterocyclyl comprising one or two 3- to 6-membering rings and 1 to 3 heteroatoms selected from N and O and optionally substituted with one or more hydroxy or R 6 ; or two R 5 , together with the atom or atoms to which they are attached, form a 3- to 5-membered saturated or 5- or 6-membered aromatic ring optionally comprising 1 or 2 heteroatoms selected from N and 0;

each R 6 is independently NR 3 C(O)R 7 or C(O)NR 3 R 7 ;

each R 7 is independently

OH, (C 1 -C 4 ) alkoxy, (C 1 -C 6 ) alkyl optionally substituted with one or more (C 1 -C 4 ) alkoxy, CF 3 , F, or (C 3 -C 10 ) cycloalkyl,

(C 3 -C 10 ) cycloalkyl optionally substituted with one or more R 8 , or

phenyl optionally substituted with one or more R 8

each R 7′ is independently H, methyl, or ethyl; or

R 7 and R 7′ , together with the atom to which they are attached, form a 3- to 6-membered ring optionally comprising one additional heteroatom selected from N and O and optionally substituted with one or more R 8 ; or

R 3 and R 7 , together with atom(s) to which they are attached, form a 3- to 6-membered ring optionally comprising one additional heteroatom selected from N and O and optionally substituted with one or more R 8 ; and

each R 8 is independently (C 1 -C 4 ) alkyl, (C 1 -C 4 ) alkoxy, CF 3 , OH, or F.

2. The compound of claim 1 , wherein the compound is of Formula (Ia′), (Ia2), (Ia2′), (Ia3), (Ia3′), or (Ib′):

or a pharmaceutically acceptable salt, solvate, stereoisomer, or tautomer thereof.

3. The compound of claim 1 , wherein L is absent, —O—, (C 1 -C 2 ) alkylene, substituted (C 1 -C 2 ) alkylene, (C 1 -C 2 ) alkylene-O—, or substituted (C 1 -C 2 ) alkylene-O—.

4. The compound of claim 1 , wherein each L 1 is independently methyl or two L 1 , together with the atom to which they are attached, form a cyclopropyl ring.

5. The compound of claim 1 , wherein each R 1 is H.

6. The compound of claim 1 , wherein

is selected from:

wherein W, W 1 and W 2 are each independently CH 2 , CHR 5 , C(R 5 ) 2 , O, NH, or NR 5 , each optionally substituted with one or more R 5 .

7. The compound of claim 1 , wherein R 3 and R 4 , together with atom(s) to which they are attached, form a 3- to 6-membered ring optionally comprising one additional heteroatom selected from N and O and optionally substituted with one or more R 5 .

8. The compound of claim 1 , wherein at least one R 5 is (C 1 -C 4 ) alkyl, (C 1 -C 4 ) alkoxy, hydroxy, cyano, oxo, C(O)R 7 , C(O)NR 7 R 7′ , NR 3 C(O)R 7 , NR'S(O) 2 R 4 , S(O) 2 R 4 , or (C 1 -C 4 ) alkyl substituted with one or more hydroxy or R 6 .

9. The compound of claim 1 , wherein at least one R 5 is (C 3 -C 10 ) cycloalkyl optionally substituted with one or more hydroxy or R 6 , or heterocyclyl comprising one or two 3- to 6-membering rings and 1 to 3 heteroatoms selected from N and O and optionally substituted with one or more hydroxy or R 6 ; or two R 5 , together with the atom or atoms to which they are attached, form a 3- to 5-membered saturated or 5- or 6-membered aromatic ring optionally comprising 1 or 2 heteroatoms selected from N and O.

10. The compound of claim 1 , wherein at least one R 7 is (C 1 -C 4 ) alkoxy, (C 1 -C 6 ) alkyl optionally substituted with one or more (C 1 -C 4 ) alkoxy, CF 3 , F, or (C 3 -C 10 ) cycloalkyl.

11. The compound of claim 1 , wherein at least one R 7 is (C 3 -C 10 ) cycloalkyl or phenyl optionally substituted with one or more R 8 .

12. The compound of claim 1 , wherein R 7 and R 7′ , together with atom(s) to which they are attached, form a 3- to 6-membered ring optionally comprising one additional heteroatom selected from N and O and optionally substituted with one or more R 8 .

13. The compound of claim 1 , wherein R 3 and R 7 , together with atom(s) to which they are attached, form a 3- to 6-membered ring optionally comprising one additional heteroatom selected from N and O and optionally substituted with one or more R 8 .

14. The compound of claim 1 , wherein at least one R 8 is (C 1 -C 4 ) alkyl or (C 1 -C 4 ) alkoxy.

15. The compound of claim 1 , wherein X is F.

16. A compound selected from

(E)-3-fluoro-2-((4-(((tetrahydro-2H-pyran-4-yl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-2-((4-(((5,5-dimethyl-1,4-dioxan-2-yl)methyl)sulfonyl)phenoxy)methyl)-3-fluoroprop-2-en-1-amine,

(S,E)-2-((4-(((5,5-dimethyl-1,4-dioxan-2-yl)methyl)sulfonyl)phenoxy)methyl)-3-fluoroprop-2-en-1-amine,

(R,E)-2-((4-(((5,5-dimethyl-1,4-dioxan-2-yl)methyl)sulfonyl)phenoxy)methyl)-3-fluoroprop-2-en-1-amine,

(E)-3-fluoro-2-((4-(((4-methyltetrahydro-2H-pyran-4-yl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-3-fluoro-2-((3-fluoro-4-(((tetrahydro-2H-pyran-4-yl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-3-fluoro-2-((3-fluoro-4-(((4-methyltetrahydro-2H-pyran-4-yl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-2-((3-chloro-4-(((tetrahydro-2H-pyran-4-yl)methyl)sulfonyl)phenoxy)methyl)-3-fluoroprop-2-en-1-amine,

(E)-3-fluoro-2-((2-fluoro-4-(((tetrahydro-2H-pyran-4-yl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)tetrahydro-2H-pyran-4-ol,

(E)-3-fluoro-2-((4-(((4-methoxytetrahydro-2H-pyran-4-yl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)tetrahydro-2H-pyran-4-carbonitrile,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)-2-fluorophenyl)sulfonyl)methyl)tetrahydro-2H-pyran-4-carbonitrile,

(1r,4r)-4-(((4-(((E)-2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)cyclohexan-1-ol,

(1s,4s)-4-(((4-(((E)-2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)cyclohexan-1-ol,

(E)-N-(1-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)cyclopropyl)cyclopropanecarboxamide,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-ol,

(E)-1-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)cyclopropan-1-ol,

(E)-3-fluoro-2-((4-((((1r,4r)-4-methoxycyclohexyl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-3-fluoro-2-((4-((((1s,4s)-4-methoxycyclohexyl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(R,E)-3-fluoro-2-((4-(((tetrahydrofuran-3-yl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(S,E)-3-fluoro-2-((4-(((tetrahydrofuran-3-yl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(S,E)-3-fluoro-2-((4-(((tetrahydrofuran-2-yl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(R,E)-3-fluoro-2-((4-(((tetrahydrofuran-2-yl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-3-fluoro-2-((4-((3-methoxy-2-(methoxymethyl)propyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-3-fluoro-2-((4-((((tetrahydro-2H-pyran-4-yl)oxy)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methoxy)piperidin-1-yl)(cyclopentyl)methanone,

(E)-3-fluoro-2-((4-((methoxymethyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-3-fluoro-2-((4-(((2-methoxyethoxy)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-3-fluoro-2-((4-((((tetrahydro-2H-pyran-4-yl)methoxy)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-3-fluoro-2-((4-((((4-methyltetrahydro-2H-pyran-4-yl)methoxy)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-4-((((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methoxy)methyl)tetrahydro-2H-pyran-4-carbonitrile,

(E)-1-(4-((((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methoxy)methyl)-4-methylpiperidin-1-yl)-2-methylpropan-1-one,

(E)-1-(4-((((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methoxy)methyl)-4-methylpiperidin-1-yl)-2,2-dimethylpropan-1-one,

(E)-(4-((((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methoxy)methyl)piperidin-1-yl)(1-(trifluoromethyl)cyclopropyl)methanone,

(E)-2-((4-((((1,3-dimethoxypropan-2-yl)oxy)methyl)sulfonyl)phenoxy)methyl)-3-fluoroprop-2-en-1-amine,

(E)-1-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)piperidin-1-yl)-2-methylpropan-1-one,

(E)-3-fluoro-2-((4-(((1-(methylsulfonyl)piperidin-4-yl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)piperidin-1-yl)(4-fluorophenyl)methanone,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)piperidin-1-yl)(3-fluorobicyclo[1.1.1]pentan-1-yl)methanone,

(E)-1-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)piperidin-1-yl)-2,2-dimethylpropan-1-one,

(E)-1-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)piperidin-1-yl)-3,3-dimethylbutan-1-one,

(E)-adamantan-1-yl(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)piperidin-1-yl)methanone

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)piperidin-1-yl)(cyclopropyl)methanone,

(E)-N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)phenyl)isobutyramide,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)phenyl)(pyrrolidin-1-yl)methanone,

(E)-(3-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)phenyl)(pyrrolidin-1-yl)methanone,

(E)-1-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)piperidin-1-yl)-2-cyclopropylethan-1-one,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)piperidin-1-yl)(1-(trifluoromethyl)cyclopropyl)methanone,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)piperidin-1-yl)(cyclobutyl)methanone,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)piperidin-1-yl)(3,3-difluorocyclobutyl)methanone,

(E)-1-(3-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)azetidin-1-yl)-2-methylpropan-1-one,

(E)-1-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-4-methylpiperidin-1-yl)-2-methylpropan-1-one,

(E)-1-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-4-methylpiperidin-1-yl)-2,2-dimethylpropan-1-one,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-4-methylpiperidin-1-yl)(1-(trifluoromethyl)cyclopropyl)methanone,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-4-methylpiperidin-1-yl)(1-methylcyclobutyl)methanone,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-4-methylpiperidin-1-yl)(1-methylcyclopropyl)methanone,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)-2-fluorophenyl)sulfonyl)methyl)piperidin-1-yl)(cyclopentyl)methanone,

(E)-1-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)-2-fluorophenyl)sulfonyl)methyl)piperidin-1-yl)-3,3,3-trifluoropropan-1-one,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)-2-chlorophenyl)sulfonyl)methyl)piperidin-1-yl)(cyclopropyl)methanone,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)(pyrrolidin-1-yl)methanone,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N,N-dimethylbicyclo[2.2.2]octane-1-carboxamide,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)(4,4-difluoropiperidin-1-yl)methanone,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-cyclobutylbicyclo[2.2.2]octane-1-carboxamide,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-(2,2,2-trifluoroethyl)bicyclo[2.2.2]octane-1-carboxamide,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-(cyclopropylmethyl)bicyclo[2.2.2]octane-1-carboxamide,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-(1-methylcyclopropyl)bicyclo[2.2.2]octane-1-carboxamide,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-(2-isopropoxyethyl)bicyclo[2.2.2]octane-1-carboxamide,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-(3,3-difluorocyclobutyl)bicyclo[2.2.2]octane-1-carboxamide,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-(tert-butyl)bicyclo[2.2.2]octane-1-carboxamide,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)(azetidin-1-yl)methanone,

(E)-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)(3,3-difluoroazetidin-1-yl)methanone,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-cyclopropyl-N-methylbicyclo[2.2.2]octane-1-carboxamide,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N,N-diethylbicyclo[2.2.2]octane-1-carboxamide,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-cyclopropylbicyclo[2.2.2]octane-1-carboxamide,

(E)-N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)cyclopropanecarboxamide,

(E)-N-(3-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[1.1.1]pentan-1-yl)pivalamide,

(E)-N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)-N-methylcyclopropanecarboxamide,

(E)-N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)-3,3,3-trifluoropropanamide,

(E)-N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)isobutyramide,

(E)-N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)cyclopropanesulfonamide,

(E)-2-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)isothiazolidine 1,1-dioxide,

(E)-1-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)-3-methylpyrrolidin-2-one,

(E)-N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)-2,2-difluorocyclopropane-1-carboxamide,

(E)-N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)-1-(trifluoromethyl)cyclopropane-1-carboxamide,

(E)-N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)-1-fluorocyclopropane-1-carboxamide,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octane-1-carbonitrile,

N-((1r,4r)-4-(((4-(((E)-2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)cyclohexyl)cyclopropanecarboxamide,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-cyclobutyl-2-(trifluoromethyl)benzamide,

(E)-N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)pivalamide,

(E)-N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)-1-methylcyclopropane-1-carboxamide,

(E)-N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)cyclobutanecarboxamide,

(R,E)-1-(3-((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)-2-methylpropyl)pyrrolidin-2-one,

(S,E)-1-(3-((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)-2-methylpropyl)pyrrolidin-2-one,

(E)-3-((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)-N-isopropyl-N,2,2-trimethylpropanamide,

(E)-N-(3-((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)-2,2-dimethylpropyl)-N-methylisobutyramide,

(E)-N-(3-((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)-2-methylpropyl)-N-ethylisobutyramide,

(E)-N-(3-((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)-2,2-dimethylpropyl)-N-ethylisobutyramide,

(E)-1-(3-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)pyrrolidin-1-yl)-2-methylpropan-1-one,

(E)-(3-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)piperidin-1-yl)(cyclopentyl)methanone,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-1-isopropylpyridin-2 (1H)-one,

(E)-6-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-2-isopropylpyridazin-3 (2H)-one,

(E)-3-fluoro-2-((4-(((2-(pyrrolidin-1-yl)pyrimidin-5-yl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(R,E)-1-(3-((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)-2-methylpropyl)piperidin-2-one,

(S,E)-1-(3-((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)-2-methylpropyl)piperidin-2-one,

(E)-1-((1-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)cyclopropyl)methyl)piperidin-2-one,

(E)-1-(2-((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)ethyl)piperidin-2-one,

(S,E)-1-(1-((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)propan-2-yl)piperidin-2-one,

(R,E)-2-(3-((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)-2-methylpropyl)-2-azaspiro[4.4]nonan-1-one,

(S,E)-2-(3-((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)-2-methylpropyl)-2-azaspiro[4.4]nonan-1-one,

(E)-1-(3-((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)-2-methylpropyl)-5,5-dimethylpyrrolidin-2-one,

(R,E)-3-fluoro-2-((4-((2-methyl-3-morpholinopropyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(S,E)-3-fluoro-2-((4-((2-methyl-3-morpholinopropyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-3-fluoro-2-((3-fluoro-4-((2-methyl-3-morpholinopropyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-2-((4-((2,2-dimethyl-3-morpholinopropyl)sulfonyl)phenoxy)methyl)-3-fluoroprop-2-en-1-amine,

(E)-3-fluoro-2-((4-(((1-(morpholinomethyl)cyclopropyl)methyl)sulfonyl)phenoxy)methyl)prop-2-en-1-amine,

(E)-1-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)pyrrolidin-2-one,

(E)-2-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)isoindolin-1-one,

(E)-1-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-3,4-dihydroquinolin-2 (1H)-one,

(E)-1′-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)spiro[cyclopropane-1,3′-indolin]-2′-one,

(E)-1-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)pyridin-2 (1H)-one,

(E)-N-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-methylisobutyramide,

(E)-1-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-5,5-dimethylpyrrolidin-2-one,

(E)-1-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)-2-chlorophenyl)sulfonyl)methyl)-5,5-dimethylpyrrolidin-2-one,

(E)-1-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-3,3-dimethylpyrrolidin-2-one,

(E)-1-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-4,4-dimethylpyrrolidin-2-one,

(E)-2-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-2-azaspiro[4.4]nonan-1-one,

(E)-2-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)-2-fluorophenyl)sulfonyl)methyl)-2-azaspiro[4.4]nonan-1-one,

(E)-1-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)piperidin-2-one,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)morpholin-3-one,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)-2-fluorophenyl)sulfonyl)methyl)morpholin-3-one,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-5,5-dimethylmorpholin-3-one,

(E)-1-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-4-pivaloylpiperazin-2-one,

(E)-1-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-4-(1-methylcyclobutane-1-carbonyl)piperazin-2-one,

(E)-1-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-4-isopropylpiperazin-2-one,

(5r,8r)-8-(((4-(((E)-2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-2-isopropyl-2-azaspiro[4.5]decan-1-one,

(5s,8s)-8-(((4-(((E)-2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-2-isopropyl-2-azaspiro[4.5]decan-1-one,

(E)-3-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-cyclobutylbicyclo[1.1.1]pentane-1-carboxamide,

(Z)—N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)cyclopropanecarboxamide,

(Z)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-cyclobutylbicyclo[2.2.2]octane-1-carboxamide,

(Z)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-(tert-butyl)bicyclo[2.2.2]octane-1-carboxamide,

(Z)—N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octan-1-yl)pivalamide,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-cyclobutylbicyclo[2.2.1]heptane-1-carboxamide,

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)-N-isopropylcyclohexane-1-carboxamide,

(E)-N-(4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.1]heptan-1-yl)pivalamide, and

(E)-4-(((4-((2-(aminomethyl)-3-fluoroallyl)oxy)phenyl)sulfonyl)methyl)bicyclo[2.2.2]octane-1-carboxylic acid,

or a pharmaceutically acceptable salt, solvate, stereoisomer, or tautomer thereof.

17. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt, solvate, stereoisomer, or tautomer thereof, and a pharmaceutically acceptable diluent, excipient or carrier.

18. A method of modulating SSAO or treating a SSAO-mediated disorder, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt, solvate, stereoisomer, or tautomer thereof, wherein the SSAO-mediated disorder is liver inflammation, liver fibrosis, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, or stroke.

19. The compound of claim 16 , wherein the compound is selected from the group consisting of:

or a pharmaceutically acceptable salt, solvate, stereoisomer, or tautomer thereof.

20. The compound of claim 1 , wherein m is 1 or 2.

21. The compound of claim 1 , wherein m and n are each 2.

22. The compound of claim 6 , wherein

is selected from: