IP Library › Granted Patent US 11,478,549
Granted Patent B2
US 11,478,549 · App. 17/140,782 · Granted Oct 25, 2022

Compositions and methods for treatment of pre-cancerous skin lesions

Inventors: Lynn Cornelius (St. Louis, MO); Shadmehr Demehri (St. Louis, MO); Raphael Kopan (St. Louis, MO)
Assignee: Washington University
A61K45/06A61K31/513A61K31/59A61K31/593C07D243/04A61K2300/00
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Quick Facts
Patent No.
US 11,478,549
App. No.
17/140,782
Granted
Oct 25, 2022
Kind
B2
Abstract

The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.

Claims (8)

1. A method to treat a squamous cell carcinoma, the method comprising topically administering to the squamous cell carcinoma a composition comprising a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.

2. The method of claim 1 , wherein the TSLP inducer is calcipotriol.

3. The method of claim 1 , wherein the cytotoxic agent is 5-fluorouracil (5-FU).

4. The method of claim 3 , wherein the composition comprises about 2% to about 5% 5-FU.

5. The method of claim 2 , wherein the composition comprises about 0.002% to about 0.005% calcipotriol.

6. The method of claim 1 , wherein the squamous cell carcinoma is squamous cell carcinoma in situ (SCCIS).

7. The method of claim 1 , wherein the composition is administered twice a day for 4 to 6 days.

8. The method of claim 1 , wherein the squamous cell carcinoma is reduced in size by 50% or greater.

Assignments (2)
CONFIRMATORY LICENSE Recorded Oct 26, 2023
From: WASHINGTON UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065380/0433 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 11, 2021
From: CORNELIUS, LYNN ANNE; DEMEHRI, SHADMEHR; KOPAN, RAPHAEL
To: WASHINGTON UNIVERSITY
Reel/Frame 054873/0698 →
Continuity (3)
Continuation 15510443
Provisional Application 62048586 · Sep 10, 2014
Related Publication 20210128732A1 · May 6, 2021