Organic electroluminescent materials and devices
Iridium complexes comprising three different bidentate ligands and their use in OLEDs to enhance the device efficiency and lifetime are disclosed. The complexes have a structure of the formula Ir(L A )(L B )(L C ), where ligand L A is selected from a variety of structures, ligand L B has the structure and L C has the structure In these structures, rings A, B, C, and D are each independently a 5 or 6-membered carbocyclic or heterocyclic ring; R 1 , R 2 , R 3 , R A , R B , R C , and R D can be any of a variety of substituents, and Z 1 and Z 2 are each independently C or N.
1. A compound having a formula Ir(L A )(L B )(L C );
wherein the ligand L A and the ligand L B are each independently selected from the group consisting of:
wherein the ligand L C is
wherein rings C and D are each independently a 5 or 6-membered carbocyclic or heterocyclic ring;
wherein R 1 , R 1a , R 1b , R 2 , R 2′ , R 3 , R C , and R D each independently represents mono, to a maximum possible number of substitutions, or no substitution;
wherein X 1 to X 12 , Z 1 and Z 2 are each independently C or N;
wherein Y 1 is selected from the group consisting of O, S, Se, and Ge;
wherein X is selected from the group consisting of BR′, NR′, PR′, O, S, Se, C═O, S═O, SO 2 , CR′R″, SiR′R″, and GeR′R″;
wherein L A , L B , and L C are different from each other, and can be connected to each other to form multidentate ligand;
wherein, when present, at least one substituent R 2′ comprises aryl or heteroaryl and can be further substituted by one or more moieties selected from the group consisting of deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof;
wherein R 1 , R 1a , R 1b , R 2 , R 2′ , R 3 , R A , R B , R C , R D , R′, and R″ are each independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof;
wherein any two or more substituents among possible ring forming substituents are optionally joined or fused into a ring;
wherein R 1a , R 1b , R 2 , R 2′ , R 3 , R A , R C , R D , R′, and R″ are possible ring forming substituents;
wherein (a) at least four of R 1 , R 2 , and R 2′ comprises a moiety selected from the group consisting of alkyl, cycloalkyl, aryl and heteroaryl,
(b) at least three of R 1 , R 2 , and R 2′ comprises alkyl, cycloalkyl, aryl, or heteroaryl, with at least one of R 1 , R 2 , and R 2′ comprising cycloalkyl, aryl, or heteroaryl,
(c)(i) L A and L B are both selected from the croup consisting of
(ii) at least three of R 1 , R 2 , and R 3 comprise alkyl, cycloalkyl, aryl, or heteroaryl, and (iii) exactly one of X 5 to X 10 is N, or at least one X is selected from the group consisting of BR′, NR′, PR′, Se, C═O, S═O, SO2, CR′R″, SiR′R″, or GeR′R″, or
(d) any combination of (a), (b), or (c);
wherein:
if Z 1 is C or Ring B is a five-membered carbocyclic or heterocyclic ring, then R B is one of the possible ring forming substituents, and
if Z 1 is N, then (i) at least one R B comprises aryl or heteroaryl and the R B substituents are not joined or fused into a ring, or (ii) at least one R A or R B comprises cycloalkyl; and
wherein:
if Z 2 is C or Ring D is a five-membered carbocyclic or heterocyclic ring, then R D is one of the possible ring forming substituents, and
if Z 2 is N, then R D substituents are not joined or fused into a ring.
2. The compound of claim 1 , wherein the ring A and C is benzene, and the ring is pyridine.
3. The compound of claim 1 , wherein the rings C and D are each independently selected from the group consisting of phenyl, pyridine, imidazole, and imidazole derived carbene.
4. The compound of claim 1 , wherein Z 2 is N.
5. The compound of claim 1 , wherein at least one X is selected from the group consisting of NR′, O, CR′R″, and SiR′R″.
6. The compound of claim 1 , wherein at least four of R 1 , R 2 , and R 2′ comprises a moiety selected from the group consisting of alkyl, cycloalkyl, aryl and heteroaryl.
7. The compound of claim 1 , wherein at least one of L A , L B , and L C is selected from the group consisting of:
where i in Ai is 1 to 192 and 194 to 212 and the substituents in L a Ai to L k Ai are defined as,
L a Ai to
L k Ai,
where
i is
R 1a
R 1b
R 2
R 3a
R 3b
R 3c
1.
H
H
H
H
H
H
2.
H
CH3
H
H
H
H
3.
H
CD3
H
H
H
H
4.
H
C2H5
H
H
H
H
5.
H
CD2CH3
H
H
H
H
6.
H
CHMe2
H
H
H
H
7.
H
CDMe2
H
H
H
H
8.
H
H
H
H
H
9.
H
H
H
H
H
10.
H
H
H
H
H
11.
H
H
H
H
H
12.
H
H
H
H
H
13.
H
H
H
H
H
14.
H
H
H
H
H
15.
H
H
H
H
H
16.
H
H
H
H
H
17.
H
CH2CMe3
H
H
H
H
18.
H
CD2CMe3
H
H
H
H
19.
H
H
H
H
H
20.
H
H
H
H
H
21.
CH3
H
H
H
H
H
22.
CD3
H
H
H
H
H
23.
C2H5
H
H
H
H
H
24.
CD2CH3
H
H
H
H
H
25.
CHMe2
H
H
H
H
H
26.
CDMe2
H
H
H
H
H
27.
H
H
H
H
H
28.
H
H
H
H
H
29.
H
H
H
H
H
30.
H
H
H
H
H
31.
H
H
H
H
H
32.
H
H
H
H
H
33.
H
H
H
H
H
34.
H
H
H
H
H
35.
H
H
H
H
H
36.
CH2CMe3
H
H
H
H
H
37.
CD2CMe3
H
H
H
H
H
38.
H
H
H
H
H
39.
H
H
H
H
H
40.
CD3
CH3
H
H
H
H
41.
CD3
CD3
H
H
H
H
42.
CD3
C2H5
H
H
H
H
43.
CD3
CD2CH3
H
H
H
H
44.
CD3
CHMe2
H
H
H
H
45.
CD3
CDMe2
H
H
H
H
46.
CD3
H
H
H
H
47.
CD3
H
H
H
H
48.
CD3
H
H
H
H
49.
CD3
H
H
H
H
50.
CD3
H
H
H
H
51.
CD3
H
H
H
H
52.
CD3
H
H
H
H
53.
CD3
H
H
H
H
54.
CD3
H
H
H
H
55.
CD3
CH2CMe3
H
H
H
H
56.
CD3
CD2CMe3
H
H
H
H
57.
CH2CH3
CD3
H
H
H
H
58.
CD2CD3
CD3
H
H
H
H
59.
C2H5
CD3
H
H
H
H
60.
CD2CH3
CD2CD3
H
H
H
H
61.
CHMe2
CD3
H
H
H
H
62.
CDMe2
CD3
H
H
H
H
63.
CD3
H
H
H
H
64.
CD3
H
H
H
H
65.
CD3
H
H
H
H
66.
CD3
H
H
H
H
67.
CD3
H
H
H
H
68.
CD3
H
H
H
H
69.
CD3
H
H
H
H
70.
CD3
H
H
H
H
71.
CD3
H
H
H
H
72.
CH2CMe3
CD3
H
H
H
H
73.
CD2CMe3
CD3
H
H
H
H
74.
H
H
CD3
H
H
H
75.
H
CH3
CD3
H
H
H
76.
H
CD3
CD3
H
H
H
77.
H
C2H5
CD3
H
H
H
78.
H
CD2CH3
CD3
H
H
H
79.
H
CHMe2
CD3
H
H
H
80.
H
CDMe2
CD3
H
H
H
81.
H
CD3
H
H
H
82.
H
CD3
H
H
H
83.
H
CD3
H
H
H
84.
H
CD3
H
H
H
85.
H
CD3
H
H
H
86.
H
CD3
H
H
H
87.
H
CD3
H
H
H
88.
H
1-Ad
CD3
H
H
H
89.
H
CD3
H
H
H
90.
H
CH2CMe3
CD3
H
H
H
91.
H
CD2CMe3
CD3
H
H
H
92.
H
CD3
H
H
H
93.
H
CD3
H
H
H
94.
H
2-Ad
CD3
H
H
H
95.
H
H
CD3
H
H
CD3
96.
H
CH3
CD3
H
H
CD3
97.
H
CD3
CD3
H
H
CD3
98.
H
C2H5
CD3
H
H
CD3
99.
H
CD2CH3
CD3
H
H
CD3
100.
H
CHMe2
CD3
H
H
CD3
101.
H
CDMe2
CD3
H
H
CD3
102.
H
CD3
H
H
CD3
103.
H
CD3
H
H
CD3
104.
H
CD3
H
H
CD3
105.
H
CD3
H
H
CD3
106.
H
CD3
H
H
CD3
107.
H
CD3
H
H
CD3
108.
H
CD3
H
H
CD3
109.
H
1-Ad
CD3
H
H
CD3
110.
H
CD3
H
H
CD3
111.
H
CH2CMe3
CD3
H
H
CD3
112.
H
CD2CMe3
CD3
H
H
CD3
113.
H
CD3
H
H
CD3
114.
H
CD3
H
H
CD3
115.
H
2-Ad
CD3
H
H
H
116.
H
H
CD3
H
H
H
117.
H
CH3
CD3
H
H
H
118.
H
CD3
CD3
H
H
H
119.
H
C2H5
CD3
H
H
H
120.
H
CD2CH3
CD3
H
H
H
121.
H
CHMe2
CD3
H
H
H
122.
H
CDMe2
CD3
H
H
H
123.
H
CD3
H
H
H
124.
H
CD3
H
H
H
125.
H
CD3
H
H
H
126.
H
CD3
H
H
H
127.
H
CD3
H
H
H
128.
H
CD3
H
H
H
129.
H
CD3
H
H
H
130.
H
1-Ad
CD3
H
H
H
131.
H
CD3
H
H
H
132.
H
CH2CMe3
CD3
H
H
H
133.
H
CD2CMe3
CD3
H
H
H
134.
H
CD3
H
H
H
135.
H
CD3
H
H
H
136.
H
2-Ad
CD3
H
H
H
137.
H
H
H
H
CD3
H
138.
H
CH3
H
H
CD3
H
139.
H
CD3
H
H
CD3
H
140.
H
C2H5
H
H
CD3
H
141.
H
CD2CH3
H
H
CD3
H
142.
H
CHMe2
H
H
CD3
H
143.
H
CDMe2
H
H
CD3
H
144.
H
H
H
CD3
H
145.
H
H
H
CD3
H
146.
H
H
H
CD3
H
147.
H
H
H
CD3
H
148.
H
H
H
CD3
H
149.
H
H
H
CD3
H
150.
H
H
H
CD3
H
151.
H
H
H
CD3
H
152.
H
H
H
CD3
H
153.
H
CH2CMe3
H
H
CD3
H
154.
H
CD2CMe3
H
H
CD3
H
155.
H
H
H
CD3
H
156.
H
H
H
CD3
H
157.
H
H
H
CD3
H
H
158.
H
CH3
H
CD3
H
H
159.
H
CD3
H
CD3
H
H
160.
H
C2H5
H
CD3
H
H
161.
H
CD2CH3
H
CD3
H
H
162.
H
CHMe2
H
CD3
H
H
163.
H
CDMe2
H
CD3
H
H
164.
H
H
CD3
H
H
165.
H
H
CD3
H
H
166.
H
H
CD3
H
H
167.
H
H
CD3
H
H
168.
H
H
CD3
H
H
169.
H
H
CD3
H
H
170.
H
H
CD3
H
H
171.
H
H
CD3
H
H
172.
H
H
CD3
H
H
173.
H
CH2CMe3
H
CD3
H
H
174.
H
CD2CMe3
H
CD3
H
H
175.
H
H
CD3
H
H
176.
H
H
CD3
H
H
177.
CD3
Ph
H
H
H
H
178.
CD3
H
H
H
H
179.
CD3
H
H
H
H
180.
CD3
H
H
H
H
181.
H
Ph
H
H
H
H
182.
H
H
H
H
H
183.
H
H
H
H
H
184.
H
H
H
H
H
185.
CD3
Ph
CD3
H
H
H
186.
CD3
CD3
H
H
H
187.
CD3
CD3
H
H
H
188.
CD3
CD3
H
H
H
189.
H
Ph
CD3
H
H
H
190.
H
CD3
H
H
H
191.
H
CD3
H
H
H
192.
H
CD3
H
H
H
193.
H
H
H
H
H
H
194.
H
CH3
H
H
H
H
195.
H
CD3
H
H
H
H
196.
H
C2H5
H
H
H
H
197.
H
CD2CH3
H
H
H
H
198.
H
CHMe2
H
H
H
H
199.
H
CDMe2
H
H
H
H
200.
H
H
H
H
H
201.
H
H
H
H
H
202.
H
H
H
H
H
203.
H
H
H
H
H
204.
H
H
H
H
H
205.
H
H
H
H
H
206.
H
H
H
H
H
207.
H
H
H
H
H
208.
H
H
H
H
H
209.
CD3
CD3
H
H
CD3
H
210.
H
CD3
H
CD3
H
CD3
211.
CD3
H
CD3
H
H
H
212.
CD3
H
CD3
H
H
and L i , wherein L i is wherein for each i from 1 to 1462, R B1 , R B2 , R B3 , and R B4 are defined as follows for each i:
i in Li
R B1
R B2
R B3
R B4
R B5
1.
H
H
H
H
H
2.
CH 3
H
H
H
H
3.
H
CH 3
H
H
H
4.
H
H
CH 3
H
H
5.
CH 3
CH 3
H
CH 3
H
6.
CH 3
H
CH 3
H
H
7.
CH 3
H
H
CH 3
H
8.
H
CH 3
CH 3
H
H
9.
H
CH 3
H
CH 3
H
10.
H
H
CH 3
CH 3
H
11.
CH 3
CH 3
CH 3
H
H
12.
CH 3
CH 3
H
CH 3
H
13.
CH 3
H
CH 3
CH 3
H
14.
H
CH 3
CH 3
CH 3
H
15.
CH 3
CH 3
CH 3
CH 3
H
16.
CH 2 CH 3
H
H
H
H
17.
CH 2 CH 3
CH 3
H
CH 3
H
18.
CH 2 CH 3
H
CH 3
H
H
19.
CH 2 CH 3
H
H
CH 3
H
20.
CH 2 CH 3
CH 3
CH 3
H
H
21.
CH 2 CH 3
CH 3
H
CH 3
H
22.
CH 2 CH 3
H
CH 3
CH 3
H
23.
CH 2 CH 3
CH 3
CH 3
CH 3
H
24.
H
CH 2 CH 3
H
H
H
25.
CH 3
CH 2 CH 3
H
CH 3
H
26.
H
CH 2 CH 3
CH 3
H
H
27.
H
CH 2 CH 3
H
CH 3
H
28.
CH 3
CH 2 CH 3
CH 3
H
H
29.
CH 3
CH 2 CH 3
H
CH 3
H
30.
H
CH 2 CH 3
CH 3
CH 3
H
31.
CH 3
CH 2 CH 3
CH 3
CH 3
H
32.
H
H
CH 2 CH 3
H
H
33.
CH 3
H
CH 2 CH 3
H
H
34.
H
CH 3
CH 2 CH 3
H
H
35.
H
H
CH 2 CH 3
CH 3
H
36.
CH 3
CH 3
CH 2 CH 3
H
H
37.
CH 3
H
CH 2 CH 3
CH 3
H
38.
H
CH 3
CH 2 CH 3
CH 3
H
39.
CH 3
CH 3
CH 2 CH 3
CH 3
H
40.
CH(CH 3 ) 2
H
H
H
H
41.
CH(CH 3 ) 2
CH 3
H
CH 3
H
42.
CH(CH 3 ) 2
H
CH 3
H
H
43.
CH(CH 3 ) 2
H
H
CH 3
H
44.
CH(CH 3 ) 2
CH 3
CH 3
H
H
45.
CH(CH 3 ) 2
CH 3
H
CH 3
H
46.
CH(CH 3 ) 2
H
CH 3
CH 3
H
47.
CH(CH 3 ) 2
CH 3
CH 3
CH 3
H
48.
H
CH(CH 3 ) 2
H
H
H
49.
CH 3
CH(CH 3 ) 2
H
CH 3
H
50.
H
CH(CH 3 ) 2
CH 3
H
H
51.
H
CH(CH 3 ) 2
H
CH 3
H
52.
CH 3
CH(CH 3 ) 2
CH 3
H
H
53.
CH3
CH(CH 3 ) 2
H
CH 3
H
54.
H
CH(CH 3 ) 2
CH 3
CH 3
H
55.
CH 3
CH(CH 3 ) 2
CH 3
CH 3
H
56.
H
H
CH(CH 3 ) 2
H
H
57.
CH 3
H
CH(CH 3 ) 2
H
H
58.
H
CH 3
CH(CH 3 ) 2
H
H
59.
H
H
CH(CH 3 ) 2
CH 3
H
60.
CH 3
CH 3
CH(CH 3 ) 2
H
H
61.
CH 3
H
CH(CH 3 ) 2
CH 3
H
62.
H
CH 3
CH(CH 3 ) 2
CH 3
H
63.
CH 3
CH 3
CH(CH 3 ) 2
CH 3
H
64.
CH 2 CH(CH 3 ) 2
H
H
H
H
65.
CH 2 CH(CH 3 ) 2
CH 3
H
CH 3
H
66.
CH 2 CH(CH 3 ) 2
H
CH 3
H
H
67.
CH 2 CH(CH 3 ) 2
H
H
CH 3
H
68.
CH 2 CH(CH 3 ) 2
CH 3
CH 3
H
H
69.
CH 2 CH(CH 3 ) 2
CH 3
H
CH 3
H
70.
CH 2 CH(CH 3 ) 2
H
CH 3
CH 3
H
71.
CH 2 CH(CH 3 ) 2
CH 3
CH 3
CH 3
H
72.
H
CH 2 CH(CH 3 ) 2
H
H
H
73.
CH 3
CH 2 CH(CH 3 ) 2
H
CH 3
H
74.
H
CH 2 CH(CH 3 ) 2
CH 3
H
H
75.
H
CH 2 CH(CH 3 ) 2
H
CH 3
H
76.
CH 3
CH 2 CH(CH 3 ) 2
CH 3
H
H
77.
CH 3
CH 2 CH(CH 3 ) 2
H
CH 3
H
78.
H
CH 2 CH(CH 3 ) 2
CH 3
CH 3
H
79.
CH 3
CH 2 CH(CH 3 ) 2
CH 3
CH 3
H
80.
H
H
CH 2 CH(CH 3 ) 2
H
H
81.
CH 3
H
CH 2 CH(CH 3 ) 2
H
H
82.
H
CH 3
CH 2 CH(CH 3 ) 2
H
H
83.
H
H
CH 2 CH(CH 3 ) 2
CH 3
H
84.
CH 3
CH 3
CH 2 CH(CH 3 ) 2
H
H
85.
CH 3
H
CH 2 CH(CH 3 ) 2
CH 3
H
86.
H
CH 3
CH 2 CH(CH 3 ) 2
CH 3
H
87.
CH 3
CH 3
CH 2 CH(CH 3 ) 2
CH 3
H
88.
C(CH 3 ) 3
H
H
H
H
89.
C(CH 3 ) 3
CH 3
H
CH 3
H
90.
C(CH 3 ) 3
H
CH 3
H
H
91.
C(CH 3 ) 3
H
H
CH 3
H
92.
C(CH 3 ) 3
CH 3
CH 3
H
H
93.
C(CH 3 ) 3
CH 3
H
CH 3
H
94.
C(CH 3 ) 3
H
CH 3
CH 3
H
95.
C(CH 3 ) 3
CH 3
CH 3
CH 3
H
96.
H
C(CH 3 ) 3
H
H
H
97.
CH 3
C(CH 3 ) 3
H
CH 3
H
98.
H
C(CH 3 ) 3
CH 3
H
H
99.
H
C(CH 3 ) 3
H
CH 3
H
100.
CH 3
C(CH 3 ) 3
CH 3
H
H
101.
CH 3
C(CH 3 ) 3
H
CH 3
H
102.
H
C(CH 3 ) 3
CH 3
CH 3
H
103.
CH 3
C(CH 3 ) 3
CH 3
CH 3
H
104.
H
H
C(CH 3 ) 3
H
H
105.
CH 3
H
C(CH 3 ) 3
H
H
106.
H
CH 3
C(CH 3 ) 3
H
H
107.
H
H
C(CH 3 ) 3
CH 3
H
108.
CH 3
CH 3
C(CH 3 ) 3
H
H
109.
CH 3
H
C(CH 3 ) 3
CH 3
H
110.
H
CH 3
C(CH 3 ) 3
CH 3
H
111.
CH 3
CH 3
C(CH 3 ) 3
CH 3
H
112.
CH 2 C(CH 3 ) 3
H
H
H
H
113.
CH 2 C(CH 3 ) 3
CH 3
H
CH 3
H
114.
CH 2 C(CH 3 ) 3
H
CH 3
H
H
115.
CH 2 C(CH 3 ) 3
H
H
CH 3
H
116.
CH 2 C(CH 3 ) 3
CH 3
CH 3
H
H
117.
CH 2 C(CH 3 ) 3
CH 3
H
CH 3
H
118.
CH 2 C(CH 3 ) 3
H
CH 3
CH 3
H
119.
CH 2 C(CH 3 ) 3
CH 3
CH 3
CH 3
H
120.
H
CH 2 C(CH 3 ) 3
H
H
H
121.
CH 3
CH 2 C(CH 3 ) 3
H
CH 3
H
122.
H
CH 2 C(CH 3 ) 3
CH 3
H
H
123.
H
CH 2 C(CH 3 ) 3
H
CH 3
H
124.
CH 3
CH 2 C(CH 3 ) 3
CH 3
H
H
125.
CH 3
CH 2 C(CH 3 ) 3
H
CH 3
H
126.
H
CH 2 C(CH 3 ) 3
CH 3
CH 3
H
127.
CH 3
CH 2 C(CH 3 ) 3
CH 3
CH 3
H
128.
H
H
CH 2 C(CH 3 ) 3
H
H
129.
CH 3
H
CH 2 C(CH 3 ) 3
H
H
130.
H
CH 3
CH 2 C(CH 3 ) 3
H
H
131.
H
H
CH 2 C(CH 3 ) 3
CH 3
H
132.
CH 3
CH 3
CH 2 C(CH 3 ) 3
H
H
133.
CH 3
H
CH 2 C(CH 3 ) 3
CH 3
H
134.
H
CH 3
CH 2 C(CH 3 ) 3
CH 3
H
135.
CH 3
CH 3
CH 2 C(CH 3 ) 3
CH 3
H
136.
H
H
H
H
137.
CH 3
H
CH 3
H
138.
H
CH 3
H
H
139.
H
H
CH 3
H
140.
CH 3
CH 3
H
H
141.
CH 3
H
CH 3
H
142.
H
CH 3
CH 3
H
143.
CH 3
CH 3
CH 3
H
144.
H
H
H
H
145.
CH 3
H
CH 3
H
146.
H
CH 3
H
H
147.
H
H
CH 3
H
148.
CH 3
CH 3
H
H
149.
CH 3
H
CH 3
H
150.
H
CH 3
CH 3
H
151.
CH 3
CH 3
CH 3
H
152.
H
H
H
H
153.
CH 3
H
H
H
154.
H
CH 3
H
H
155.
H
H
CH 3
H
156.
CH 3
CH 3
H
H
157.
CH 3
H
CH 3
H
158.
H
CH 3
CH 3
H
159.
CH 3
CH 3
CH 3
H
160.
H
H
H
H
161.
CH 3
H
CH 3
H
162.
H
CH 3
H
H
163.
H
H
CH 3
H
164.
CH 3
CH 3
H
H
165.
CH 3
H
CH 3
H
166.
H
CH 3
CH 3
H
167.
CH 3
CH 3
CH 3
H
168.
H
H
H
H
169.
CH 3
H
CH 3
H
170.
H
CH 3
H
H
171.
H
H
CH 3
H
172.
CH 3
CH 3
H
H
173.
CH 3
H
CH 3
H
174.
H
CH 3
CH 3
H
175.
CH 3
CH 3
CH 3
H
176.
H
H
H
H
177.
CH 3
H
H
H
178.
H
CH 3
H
H
179.
H
H
CH 3
H
180.
CH 3
CH 3
H
H
181.
CH 3
H
CH 3
H
182.
H
CH 3
CH 3
H
183.
CH 3
CH 3
CH 3
H
184.
H
H
H
H
185.
CH 3
H
CH 3
H
186.
H
CH 3
H
H
187.
H
H
CH 3
H
188.
CH 3
CH 3
H
H
189.
CH 3
H
CH 3
H
190.
H
CH 3
CH 3
H
191.
CH 3
CH 3
CH 3
H
192.
H
H
H
H
193.
CH 3
H
CH 3
H
194.
H
CH 3
H
H
195.
H
H
CH 3
H
196.
CH 3
CH 3
H
H
197.
CH 3
H
CH 3
H
198.
H
CH 3
CH 3
H
199.
CH 3
CH 3
CH 3
H
200.
H
H
H
H
201.
CH 3
H
H
H
202.
H
CH 3
H
H
203.
H
H
CH 3
H
204.
CH 3
CH 3
H
H
205.
CH 3
H
CH 3
H
206.
H
CH 3
CH 3
H
207.
CH 3
CH 3
CH 3
H
208.
H
H
H
H
209.
CH 3
H
CH 3
H
210.
H
CH 3
H
H
211.
H
H
CH 3
H
212.
CH 3
CH 3
H
H
213.
CH 3
H
CH 3
H
214.
H
CH 3
CH 3
H
215.
CH 3
CH 3
CH 3
H
216.
H
H
H
H
217.
CH 3
H
CH 3
H
218.
H
CH 3
H
H
219.
H
H
CH 3
H
220.
CH 3
CH 3
H
H
221.
CH 3
H
CH 3
H
222.
H
CH 3
CH 3
H
223.
CH 3
CH 3
CH 3
H
224.
H
H
H
H
225.
CH 3
H
H
H
226.
H
CH 3
H
H
227.
H
H
CH 3
H
228.
CH 3
CH 3
H
H
229.
CH 3
H
CH 3
H
230.
H
CH 3
CH 3
H
231.
CH 3
CH 3
CH 3
H
232.
H
H
H
H
233.
CH 3
H
CH 3
H
234.
H
CH 3
H
H
235.
H
H
CH 3
H
236.
CH 3
CH 3
H
H
237.
CH 3
H
CH 3
H
238.
H
CH 3
CH 3
H
239.
CH 3
CH 3
CH 3
H
240.
H
H
H
H
241.
CH 3
H
CH 3
H
242.
H
CH 3
H
H
243.
H
H
CH 3
H
244.
CH 3
CH 3
H
H
245.
CH 3
H
CH 3
H
246.
H
CH 3
CH 3
H
247.
CH 3
CH 3
CH 3
H
248.
H
H
H
H
249.
CH 3
H
H
H
250.
H
CH 3
H
H
251.
H
H
CH 3
H
252.
CH 3
CH 3
H
H
253.
CH 3
H
CH 3
H
254.
H
CH 3
CH 3
H
255.
CH 3
CH 3
CH 3
H
256.
H
H
H
H
257.
CH 3
H
CH 3
H
258.
H
CH 3
H
H
259.
H
H
CH 3
H
260.
CH 3
CH 3
H
H
261.
CH 3
H
CH 3
H
262.
H
CH 3
CH 3
H
263.
CH 3
CH 3
CH 3
H
264.
H
H
H
H
265.
CH 3
H
CH 3
H
266.
H
CH 3
H
H
267.
H
H
CH 3
H
268.
CH 3
CH 3
H
H
269.
CH 3
H
CH 3
H
270.
H
CH 3
CH 3
H
271.
CH 3
CH 3
CH 3
H
272.
H
H
H
H
273.
CH 3
H
H
H
274.
H
CH 3
H
H
275.
H
H
CH 3
H
276.
CH 3
CH 3
H
H
277.
CH 3
H
CH 3
H
278.
H
CH 3
CH 3
H
279.
CH 3
CH 3
CH 3
H
280.
CH(CH 3 ) 2
H
CH 2 CH 3
H
H
281.
CH(CH 3 ) 2
H
CH(CH 3 ) 2
H
H
282.
CH(CH 3 ) 2
H
CH 2 CH(CH 3 ) 2
H
H
283.
CH(CH 3 ) 2
H
C(CH 3 ) 3
H
H
284.
CH(CH 3 ) 2
H
CH 2 C(CH 3 ) 3
H
H
285.
CH(CH 3 ) 2
H
H
H
286.
CH(CH 3 ) 2
H
H
H
287.
CH(CH 3 ) 2
H
H
H
288.
CH(CH 3 ) 2
H
H
H
289.
CH(CH 3 ) 2
H
H
H
290.
CH(CH 3 ) 2
H
H
H
291.
C(CH 3 ) 3
H
CH 2 CH 3
H
H
292.
C(CH 3 ) 3
H
CH(CH 3 ) 2
H
H
293.
C(CH 3 ) 3
H
CH 2 CH(CH 3 ) 2
H
H
294.
C(CH 3 ) 3
H
C(CH 3 ) 3
H
H
295.
C(CH 3 ) 3
H
CH 2 C(CH 3 ) 3
H
H
296.
C(CH 3 ) 3
H
H
H
297.
C(CH 3 ) 3
H
H
H
298.
C(CH 3 ) 3
H
H
H
299.
C(CH 3 ) 3
H
H
H
300.
C(CH 3 ) 3
H
H
H
301.
C(CH 3 ) 3
H
H
H
302.
CH 2 C(CH 3 ) 3
H
CH 2 CH 3
H
H
303.
CH 2 C(CH 3 ) 3
H
CH(CH 3 ) 2
H
H
304.
CH 2 C(CH 3 ) 3
H
CH 2 CH(CH 3 ) 2
H
H
305.
CH 2 C(CH 3 ) 3
H
C(CH 3 ) 3
H
H
306.
CH 2 C(CH 3 ) 3
H
CH 2 C(CH 3 ) 3
H
H
307.
CH 2 C(CH 3 ) 3
H
CH 2 CH 2 CF 3
H
H
308.
CH 2 C(CH 3 ) 3
H
CH 2 C(CH 3 ) 2 CF 3
H
H
309.
CH 2 C(CH 3 ) 3
H
H
H
310.
CH 2 C(CH 3 ) 3
H
H
H
311.
CH 2 C(CH 3 ) 3
H
H
H
312.
CH 2 C(CH 3 ) 3
H
H
H
313.
CH 2 C(CH 3 ) 3
H
H
H
314.
CH 2 C(CH 3 ) 3
H
H
H
315.
H
CH 2 CH 3
H
H
316.
H
CH(CH 3 ) 2
H
H
317.
H
CH 2 CH(CH 3 ) 2
H
H
318.
H
C(CH 3 ) 3
H
H
319.
H
CH 2 C(CH 3 ) 3
H
H
320.
H
H
H
321.
H
H
H
322.
H
H
H
323.
H
H
H
324.
H
H
H
325.
H
H
H
326.
H
CH 2 CH 3
H
H
327.
H
CH(CH 3 ) 2
H
H
328.
H
CH 2 CH(CH 3 ) 2
H
H
329.
H
C(CH 3 ) 3
H
H
330.
H
CH 2 C(CH 3 ) 3
H
H
331.
H
H
H
332.
H
H
H
333.
H
H
H
334.
H
H
H
335.
H
H
H
336.
H
H
H
337.
H
CH 2 CH(CH 3 ) 2
H
H
338.
H
C(CH 3 ) 3
H
H
339.
H
CH 2 C(CH 3 ) 3
H
H
340.
H
H
H
341.
H
H
H
342.
H
H
H
343.
H
H
H
344.
H
H
H
345.
H
H
H
346.
H
CH 2 CH(CH 3 ) 2
H
H
347.
H
C(CH 3 ) 3
H
H
348.
H
CH 2 C(CH 3 ) 3
H
H
349.
H
H
H
350.
H
H
H
351.
H
H
H
352.
H
H
H
353.
H
H
H
354.
H
H
H
355.
H
CH 2 CH(CH 3 ) 2
H
H
356.
H
C(CH 3 ) 3
H
H
357.
H
CH 2 C(CH 3 ) 3
H
H
358.
H
H
H
359.
H
H
H
360.
H
H
H
361.
H
H
H
362.
H
H
H
363.
H
H
H
364.
H
H
H
H
H
365.
CD 3
H
H
H
H
366.
H
CD 3
H
H
H
367.
H
H
CD 3
H
H
368.
CD 3
CD 3
H
CD 3
H
369.
CD 3
H
CD 3
H
H
370.
CD 3
H
H
CD 3
H
371.
H
CD 3
CD 3
H
H
372.
H
CD 3
H
CD 3
H
373.
H
H
CD 3
CD 3
H
374.
CD 3
CD 3
CD 3
H
H
375.
CD 3
CD 3
H
CD 3
H
376.
CD 3
H
CD 3
CD 3
H
377.
H
CD 3
CD 3
CD 3
H
378.
CD 3
CD 3
CD 3
CD 3
H
379.
CD 2 CH 3
H
H
H
H
380.
CD 2 CH 3
CD 3
H
CD 3
H
381.
CD 2 CH 3
H
CD 3
H
H
382.
CD 2 CH 3
H
H
CD 3
H
383.
CD 2 CH 3
CD 3
CD 3
H
H
384.
CD 2 CH 3
CD 3
H
CD 3
H
385.
CD 2 CH 3
H
CD 3
CD 3
H
386.
CD 2 CH 3
CD 3
CD 3
CD 3
H
387.
H
CD 2 CH 3
H
H
H
388.
CH 3
CD 2 CH 3
H
CD 3
H
389.
H
CD 2 CH 3
CD 3
H
H
390.
H
CD 2 CH 3
H
CD 3
H
391.
CD 3
CD 2 CH 3
CD 3
H
H
392.
CD 3
CD 2 CH 3
H
CD 3
H
393.
H
CD 2 CH 3
CD 3
CD 3
H
394.
CD 3
CD 2 CH 3
CD 3
CD 3
H
395.
H
H
CD 2 CH 3
H
H
396.
CD 3
H
CD 2 CH 3
H
H
397.
H
CD 3
CD 2 CH 3
H
H
398.
H
H
CD 2 CH 3
CD 3
H
399.
CD 3
CD 3
CD 2 CH 3
H
H
400.
CD 3
H
CD 2 CH 3
CD 3
H
401.
H
CD 3
CD 2 CH 3
CD 3
H
402.
CD 3
CD 3
CD 2 CH 3
CD 3
H
403.
CD(CH 3 ) 2
H
H
H
H
404.
CD(CH 3 ) 2
CD 3
H
CD 3
H
405.
CD(CH 3 ) 2
H
CD 3
H
H
406.
CD(CH 3 ) 2
H
H
CD 3
H
407.
CD(CH 3 ) 2
CD 3
CD 3
H
H
408.
CD(CH 3 ) 2
CD 3
H
CD 3
H
409.
CD(CH 3 ) 2
H
CD 3
CD 3
H
410.
CD(CH 3 ) 2
CD 3
CD 3
CD 3
H
411.
H
CD(CH 3 ) 2
H
H
H
412.
CD 3
CD(CH 3 ) 2
H
CD 3
H
413.
H
CD(CH 3 ) 2
CD 3
H
H
414.
H
CD(CH 3 ) 2
H
CD 3
H
415.
CD 3
CD(CH 3 ) 2
CD 3
H
H
416.
CD 3
CD(CH 3 ) 2
H
CD 3
H
417.
H
CD(CH 3 ) 2
CD 3
CD 3
H
418.
CD 3
CD(CH 3 ) 2
CD 3
CD 3
H
419.
H
H
CD(CH 3 ) 2
H
H
420.
CD 3
H
CD(CH 3 ) 2
H
H
421.
H
CD 3
CD(CH 3 ) 2
H
H
422.
H
H
CD(CH 3 ) 2
CD 3
H
423.
CD 3
CD 3
CD(CH 3 ) 2
H
H
424.
CD 3
H
CD(CH 3 ) 2
CD 3
H
425.
H
CD 3
CD(CH 3 ) 2
CD 3
H
426.
CD 3
CD 3
CD(CH 3 ) 2
CD 3
H
427.
CD(CD 3 ) 2
H
H
H
H
428.
CD(CD 3 ) 2
CD 3
H
CD 3
H
429.
CD(CD 3 ) 2
H
CD 3
H
H
430.
CD(CD 3 ) 2
H
H
CD 3
H
431.
CD(CD 3 ) 2
CD 3
CD 3
H
H
432.
CD(CD 3 ) 2
CD 3
H
CD 3
H
433.
CD(CD 3 ) 2
H
CD 3
CD 3
H
434.
CD(CD 3 ) 2
CD 3
CD 3
CD 3
H
435.
H
CD(CD 3 ) 2
H
H
H
436.
CD 3
CD(CD 3 ) 2
H
CD 3
H
437.
H
CD(CD 3 ) 2
CD 3
H
H
438.
H
CD(CD 3 ) 2
H
CD 3
H
439.
CD 3
CD(CD 3 ) 2
CD 3
H
H
440.
CD 3
CD(CD 3 ) 2
H
CD 3
H
441.
H
CD(CD 3 ) 2
CD 3
CD 3
H
442.
CD 3
CD(CD 3 ) 2
CD 3
CD 3
H
443.
H
H
CD(CD 3 ) 2
H
H
444.
CD 3
H
CD(CD 3 ) 2
H
H
445.
H
CD 3
CD(CD 3 ) 2
H
H
446.
H
H
CD(CD 3 ) 2
CD 3
H
447.
CD 3
CD 3
CD(CD 3 ) 2
H
H
448.
CD 3
H
CD(CD 3 ) 2
CD 3
H
449.
H
CD 3
CD(CD 3 ) 2
CD 3
H
450.
CD 3
CD 3
CD(CD 3 ) 2
CD 3
H
451.
CD 2 CH(CH 3 ) 2
H
H
H
H
452.
CD 2 CH(CH 3 ) 2
CD 3
H
CD 3
H
453.
CD 2 CH(CH 3 ) 2
H
CD 3
H
H
454.
CD 2 CH(CH 3 ) 2
H
H
CD 3
H
455.
CD 2 CH(CH 3 ) 2
CD 3
CD 3
H
H
456.
CD 2 CH(CH 3 ) 2
CD 3
H
CD 3
H
457.
CD 2 CH(CH 3 ) 2
H
CD 3
CD 3
H
458.
CD 2 CH(CH 3 ) 2
CD 3
CD 3
CD 3
H
459.
H
CD 2 CH(CH 3 ) 2
H
H
H
460.
CD 3
CD 2 CH(CH 3 ) 2
H
CD 3
H
461.
H
CD 2 CH(CH 3 )2
CD 3
H
H
462.
H
CD 2 CH(CH 3 )2
H
CD 3
H
463.
CD 3
CD 2 CH(CH 3 ) 2
CD 3
H
H
464.
CD 3
CD 2 CH(CH 3 ) 2
H
CD 3
H
465.
H
CD 2 CH(CH 3 ) 2
CD 3
CD 3
H
466.
CD 3
CD 2 CH(CH 3 ) 2
CD 3
CD 3
H
467.
H
H
CD 2 CH(CH 3 ) 2
H
H
468.
CD 3
H
CD 2 CH(CH 3 ) 2
H
H
469.
H
CD 3
CD 2 CH(CH 3 ) 2
H
H
470.
H
H
CD 2 CH(CH 3 ) 2
CD 3
H
471.
CD 3
CD 3
CD 2 CH(CH 3 ) 2
H
H
472.
CD 3
H
CD 2 CH(CH 3 ) 2
CD 3
H
473.
H
CD 3
CD 2 CH(CH 3 ) 2
CD 3
H
474.
CD 3
CD 3
CD 2 CH(CH 3 ) 2
CD 3
H
475.
CD 2 C(CH 3 ) 3
H
H
H
H
476.
CD 2 C(CH 3 ) 3
CD 3
H
CD 3
H
477.
CD 2 C(CH 3 ) 3
H
CD 3
H
H
478.
CD 2 C(CH 3 ) 3
H
H
CD 3
H
479.
CD 2 C(CH 3 ) 3
CD 3
CD 3
H
H
480.
CD 2 C(CH 3 ) 3
CD 3
H
CD 3
H
481.
CD 2 C(CH 3 ) 3
H
CD 3
CD 3
H
482.
CD 2 C(CH 3 ) 3
CH 3
CD 3
CD 3
H
483.
H
CD 2 C(CH 3 ) 3
H
H
H
484.
CD 3
CD 2 C(CH 3 ) 3
H
CD 3
H
485.
H
CD 2 C(CH 3 ) 3
CD 3
H
H
486.
H
CD 2 C(CH 3 ) 3
H
CD 3
H
487.
CD 3
CD 2 C(CH 3 ) 3
CD 3
H
H
488.
CD 3
CD 2 C(CH 3 ) 3
H
CD 3
H
489.
H
CD 2 C(CH 3 ) 3
CD 3
CD 3
H
490.
CD 3
CD 2 C(CH 3 ) 3
CD 3
CD 3
H
491.
H
H
CD 2 C(CH 3 ) 3
H
H
492.
CD 3
H
CD 2 C(CH 3 ) 3
H
H
493.
H
CD 3
CD 2 C(CH 3 ) 3
H
H
494.
H
H
CD 2 C(CH 3 ) 3
CD 3
H
495.
CD 3
CD 3
CD 2 C(CH 3 ) 3
H
H
496.
CD 3
H
CD 2 C(CH 3 ) 3
CD 3
H
497.
H
CD 3
CD 2 C(CH 3 ) 3
CD 3
H
498.
CD 3
CD 3
CD 2 C(CH 3 ) 3
CD 3
H
499.
H
H
H
H
500.
CD 3
H
CD 3
H
501.
H
CD 3
H
H
502.
H
H
CD 3
H
503.
CD 3
CD 3
H
H
504.
CD 3
H
CD 3
H
505.
H
CD 3
CD 3
H
506.
CD 3
CD 3
CD 3
H
507.
H
H
H
H
508.
CD 3
H
CD 3
H
509.
H
CD 3
H
H
510.
H
H
CD 3
H
511.
CD 3
CD 3
H
H
512.
CD 3
H
CD 3
H
513.
H
CD 3
CD 3
H
514.
CD 3
CD 3
CD 3
H
515.
H
H
H
H
516.
CD 3
H
H
H
517.
H
CD 3
H
H
518.
H
H
CD 3
H
519.
CD 3
CD 3
H
H
520.
CD 3
H
CD 3
H
521.
H
CD 3
CD 3
H
522.
CD 3
CD 3
CD 3
H
523.
H
H
H
H
524.
CD 3
H
CD 3
H
525.
H
CD 3
H
H
526.
H
H
CD 3
H
527.
CD 3
CD 3
H
H
528.
CD 3
H
CD 3
H
529.
H
CD 3
CD 3
H
530.
CD 3
CD 3
CD 3
H
531.
H
H
H
H
532.
CH 3
H
CD 3
H
533.
H
CD 3
H
H
534.
H
H
CD 3
H
535.
CD 3
CD 3
H
H
536.
CD 3
H
CD 3
H
537.
H
CD 3
CD 3
H
538.
CH 3
CD 3
CD 3
H
539.
H
H
H
H
540.
CD 3
H
H
H
541.
H
CD 3
H
H
542.
H
H
CD 3
H
543.
CD 3
CD 3
H
H
544.
CD 3
H
CD 3
H
545.
H
CD 3
CD 3
H
546.
CD 3
CD 3
CD 3
H
547.
H
H
H
H
548.
CD 3
H
CD 3
H
549.
H
CD 3
H
H
550.
H
H
CD 3
H
551.
CD 3
CD 3
H
H
552.
CD 3
H
CD 3
H
553.
H
CD 3
CD 3
H
554.
CD 3
CD 3
CD 3
H
555.
H
H
H
H
556.
CD 3
H
CD 3
H
557.
H
CD 3
H
H
558.
H
H
CD 3
H
559.
CD 3
CD 3
H
H
560.
CD 3
H
CD 3
H
561.
H
CD 3
CD 3
H
562.
CD 3
CD 3
CD 3
H
563.
H
H
H
H
564.
CD 3
H
H
H
565.
H
CD 3
H
H
566.
H
H
CD 3
H
567.
CD 3
CD 3
H
H
568.
CD 3
H
CD 3
H
569.
H
CD 3
CD 3
H
570.
CD 3
CD 3
CD 3
H
571.
H
H
H
H
572.
CD 3
H
CD 3
H
573.
H
CD 3
H
H
574.
H
H
CD 3
H
575.
CD 3
CD 3
H
H
576.
CD 3
H
CD 3
H
577.
H
CD 3
CD 3
H
578.
CD 3
CD 3
CD 3
H
579.
H
H
H
H
580.
CD 3
H
CD 3
H
581.
H
CD 3
H
H
582.
H
H
CD 3
H
583.
CD 3
CD 3
H
H
584.
CD 3
H
CD 3
H
585.
H
CD 3
CD 3
H
586.
CD 3
CD 3
CD 3
H
587.
H
H
H
H
588.
CD 3
H
H
H
589.
H
CD 3
H
H
590.
H
H
CD 3
H
591.
CD 3
CD 3
H
H
592.
CD 3
H
CD 3
H
593.
H
CD 3
CD 3
H
594.
CD 3
CD 3
CD 3
H
595.
H
H
H
H
596.
CD 3
H
CD 3
H
597.
H
CD 3
H
H
598.
H
H
CD 3
H
599.
CD 3
CD 3
H
H
600.
CD 3
H
CD 3
H
601.
H
CD 3
CD 3
H
602.
CD 3
CD 3
CD 3
H
603.
H
H
H
H
604.
CD 3
H
CD 3
H
605.
H
CD 3
H
H
606.
H
H
CD 3
H
607.
CD 3
CD 3
H
H
608.
CD 3
H
CD 3
H
609.
H
CD 3
CD 3
H
610.
CD 3
CD 3
CD 3
H
611.
H
H
H
H
612.
CD 3
H
H
H
613.
H
CD 3
H
H
614.
H
H
CD 3
H
615.
CD 3
CD 3
H
H
616.
CD 3
H
CD 3
H
617.
H
CD 3
CD 3
H
618.
CD 3
CD 3
CD 3
H
619.
H
H
H
H
620.
CD 3
H
CD 3
H
621.
H
CD 3
H
H
622.
H
H
CD 3
H
623.
CH 3
CH 3
H
H
624.
CD 3
H
CD 3
H
625.
H
CD 3
CD 3
H
626.
CD 3
CD 3
CD 3
H
627.
H
H
H
H
628.
CD 3
H
CD 3
H
629.
H
CD 3
H
H
630.
H
H
CD 3
H
631.
CD 3
CD 3
H
H
632.
CD 3
H
CD 3
H
633.
H
CD 3
CD 3
H
634.
CD 3
CD 3
CD 3
H
635.
H
H
H
H
636.
CD 3
H
H
H
637.
H
CD 3
H
H
638.
H
H
CH 3
H
639.
CD 3
CD 3
H
H
640.
CD 3
H
CD 3
H
641.
H
CD 3
CD 3
H
642.
CD 3
CD 3
CD 3
H
643.
CD(CH 3 ) 2
H
CD 2 CH 3
H
H
644.
CD(CH 3 ) 2
H
CD(CH 3 ) 2
H
H
645.
CD(CH 3 ) 2
H
CD 2 CH(CH 3 ) 2
H
H
646.
CD(CH 3 ) 2
H
C(CH 3 ) 3
H
H
647.
CD(CH 3 ) 2
H
CD 2 C(CH 3 ) 3
H
H
648.
CD(CH 3 ) 2
H
H
H
649.
CD(CH 3 ) 2
H
H
H
650.
CD(CH 3 ) 2
H
H
H
651.
CD(CH 3 ) 2
H
H
H
652.
CD(CH 3 ) 2
H
H
H
653.
CD(CH 3 ) 2
H
H
H
654.
C(CH 3 ) 3
H
CD 2 CH 3
H
H
655.
C(CH 3 ) 3
H
CD(CH 3 ) 2
H
H
656.
C(CH 3 ) 3
H
CD 2 CH(CH 3 ) 2
H
H
657.
C(CH 3 ) 3
H
C(CH 3 ) 3
H
H
658.
C(CH 3 ) 3
H
CD 2 C(CH 3 ) 3
H
H
659.
C(CH 3 ) 3
H
H
H
660.
C(CH 3 ) 3
H
H
H
661.
C(CH 3 ) 3
H
H
H
662.
C(CH 3 ) 3
H
H
H
663.
C(CH 3 ) 3
H
H
H
664.
C(CH 3 ) 3
H
H
H
665.
CD 2 C(CH 3 ) 3
H
CD 2 CH 3
H
H
666.
CD 2 C(CH 3 ) 3
H
CD(CH 3 ) 2
H
H
667.
CD 2 C(CH 3 ) 3
H
CD 2 CH(CH 3 ) 2
H
H
668.
CD 2 C(CH 3 ) 3
H
C(CH 3 ) 3
H
H
669.
CD 2 C(CH 3 ) 3
H
CD 2 C(CH 3 ) 3
H
H
670.
CD 2 C(CH 3 ) 3
H
H
H
671.
CD 2 C(CH 3 ) 3
H
H
H
672.
CD 2 C(CH 3 ) 3
H
H
H
673.
CD 2 C(CH 3 ) 3
H
H
H
674.
CD 2 C(CH 3 ) 3
H
H
H
675.
CD 2 C(CH 3 ) 3
H
H
H
676.
H
CD 2 CH 3
H
H
677.
H
CD(CH 3 ) 2
H
H
678.
H
CD 2 CH(CH 3 ) 2
H
H
679.
H
C(CH 3 ) 3
H
H
680.
H
CD 2 C(CH 3 ) 3
H
H
681.
H
H
H
682.
H
H
H
683.
H
H
H
684.
H
H
H
685.
H
H
H
686.
H
H
H
687.
H
CD 2 CH 3
H
H
688.
H
CD(CH 3 ) 2
H
H
689.
H
CD 2 CH(CH 3 ) 2
H
H
690.
H
C(CH 3 ) 3
H
H
691.
H
CD 2 C(CH 3 ) 3
H
H
692.
H
H
H
693.
H
H
H
694.
H
H
H
695.
H
H
H
696.
H
H
H
697.
H
H
H
698.
H
CD 2 CH 3
H
H
699.
H
CD(CH 3 ) 2
H
H
700.
H
CD 2 CH(CH 3 ) 2
H
H
701.
H
C(CH 3 ) 3
H
H
702.
H
CD 2 C(CH 3 ) 3
H
H
703.
H
H
H
704.
H
H
H
705.
H
H
H
706.
H
H
H
707.
H
H
H
708.
H
H
H
709.
H
CD 2 CH 3
H
H
710.
H
CD(CH 3 ) 2
H
H
711.
H
CD 2 CH(CH 3 ) 2
H
H
712.
H
C(CH 3 ) 3
H
H
713.
H
CD 2 C(CH 3 ) 3
H
H
714.
H
H
H
715.
H
H
H
716.
H
H
H
717.
H
H
H
718.
H
H
H
719.
H
H
H
720.
H
CD 2 CH 3
H
H
721.
H
CD(CH 3 ) 2
H
H
722.
H
CD 2 CH(CH 3 ) 2
H
H
723.
H
C(CH 3 ) 3
H
H
724.
H
CD 2 C(CH 3 ) 3
H
H
725.
H
H
H
726.
H
H
H
727.
H
H
H
728.
H
H
H
729.
H
H
H
730.
H
H
H
731.
H
H
H
H
Ph
732.
CH 3
H
H
H
Ph
733.
H
CH 3
H
H
Ph
734.
H
H
CH 3
H
Ph
735.
CH 3
CH 3
H
CH 3
Ph
736.
CH 3
H
CH 3
H
Ph
737.
CH 3
H
H
CH 3
Ph
738.
H
CH 3
CH 3
H
Ph
739.
H
CH 3
H
CH 3
Ph
740.
H
H
CH 3
CH 3
Ph
741.
CH 3
CH 3
CH 3
H
Ph
742.
CH 3
CH 3
H
CH 3
Ph
743.
CH 3
H
CH 3
CH 3
Ph
744.
H
CH 3
CH 3
CH 3
Ph
745.
CH 3
CH 3
CH 3
CH 3
Ph
746.
CH 2 CH 3
H
H
H
Ph
747.
CH 2 CH 3
CH 3
H
CH 3
Ph
748.
CH 2 CH 3
H
CH 3
H
Ph
749.
CH 2 CH 3
H
H
CH 3
Ph
750.
CH 2 CH 3
CH 3
CH 3
H
Ph
751.
CH 2 CH 3
CH 3
H
CH 3
Ph
752.
CH 2 CH 3
H
CH 3
CH 3
Ph
753.
CH 2 CH 3
CH 3
CH 3
CH 3
Ph
754.
H
CH 2 CH 3
H
H
Ph
755.
CH 3
CH 2 CH 3
H
CH 3
Ph
756.
H
CH 2 CH 3
CH 3
H
Ph
757.
H
CH 2 CH 3
H
CH 3
Ph
758.
CH 3
CH 2 CH 3
CH 3
H
Ph
759.
CH 3
CH 2 CH 3
H
CH 3
Ph
760.
H
CH 2 CH 3
CH 3
CH 3
Ph
761.
CH 3
CH 2 CH 3
CH 3
CH 3
Ph
762.
H
H
CH 2 CH 3
H
Ph
763.
CH 3
H
CH 2 CH 3
H
Ph
764.
H
CH 3
CH 2 CH 3
H
Ph
765.
H
H
CH 2 CH 3
CH 3
Ph
766.
CH 3
CH 3
CH 2 CH 3
H
Ph
767.
CH 3
H
CH 2 CH 3
CH 3
Ph
768.
H
CH 3
CH 2 CH 3
CH 3
Ph
769.
CH 3
CH 3
CH 2 CH 3
CH 3
Ph
770.
CH(CH 3 ) 2
H
H
H
Ph
771.
CH(CH 3 ) 2
CH 3
H
CH 3
Ph
772.
CH(CH 3 ) 2
H
CH 3
H
Ph
773.
CH(CH 3 ) 2
H
H
CH 3
Ph
774.
CH(CH 3 ) 2
CH 3
CH 3
H
Ph
775.
CH(CH 3 ) 2
CH 3
H
CH 3
Ph
776.
CH(CH 3 ) 2
H
CH 3
CH 3
Ph
777.
CH(CH 3 ) 2
CH 3
CH 3
CH 3
Ph
778.
H
CH(CH 3 ) 2
H
H
Ph
779.
CH 3
CH(CH 3 ) 2
H
CH 3
Ph
780.
H
CH(CH 3 ) 2
CH 3
H
Ph
781.
H
CH(CH 3 ) 2
H
CH 3
Ph
782.
CH 3
CH(CH 3 ) 2
CH 3
H
Ph
783.
CH 3
CH(CH 3 ) 2
H
CH 3
Ph
784.
H
CH(CH 3 ) 2
CH 3
CH 3
Ph
785.
CH 3
CH(CH 3 ) 2
CH 3
CH 3
Ph
786.
H
H
CH(CH 3 ) 2
H
Ph
787.
CH 3
H
CH(CH 3 ) 2
H
Ph
788.
H
CH 3
CH(CH 3 ) 2
H
Ph
789.
H
H
CH(CH 3 ) 2
CH 3
Ph
790.
CH 3
CH 3
CH(CH 3 ) 2
H
Ph
791.
CH 3
H
CH(CH 3 ) 2
CH 3
Ph
792.
H
CH 3
CH(CH 3 ) 2
CH 3
Ph
793.
CH 3
CH 3
CH(CH 3 ) 2
CH 3
Ph
794.
CH 2 CH(CH 3 ) 2
H
H
H
Ph
795.
CH 2 CH(CH 3 ) 2
CH 3
H
CH 3
Ph
796.
CH 2 CH(CH 3 ) 2
H
CH 3
H
Ph
797.
CH 2 CH(CH 3 ) 2
H
H
CH 3
Ph
798.
CH 2 CH(CH 3 ) 2
CH 3
CH 3
H
Ph
799.
CH 2 CH(CH 3 ) 2
CH 3
H
CH 3
Ph
800.
CH 2 CH(CH 3 ) 2
H
CH 3
CH 3
Ph
801.
CH 2 CH(CH 3 ) 2
CH 3
CH 3
CH 3
Ph
802.
H
CH 2 CH(CH 3 ) 2
H
H
Ph
803.
CH 3
CH 2 CH(CH 3 ) 2
H
CH 3
Ph
804.
H
CH 2 CH(CH 3 ) 2
CH 3
H
Ph
805.
H
CH 2 CH(CH 3 ) 2
H
CH 3
Ph
806.
CH 3
CH 2 CH(CH 3 ) 2
CH 3
H
Ph
807.
CH 3
CH 2 CH(CH 3 ) 2
H
CH 3
Ph
808.
H
CH 2 CH(CH 3 ) 2
CH 3
CH 3
Ph
809.
CH 3
CH 2 CH(CH 3 ) 2
CH 3
CH 3
Ph
810.
H
H
CH 2 CH(CH 3 ) 2
H
Ph
811.
CH 3
H
CH 2 CH(CH 3 ) 2
H
Ph
812.
H
CH 3
CH 2 CH(CH 3 ) 2
H
Ph
813.
H
H
CH 2 CH(CH 3 ) 2
CH 3
Ph
814.
CH 3
CH 3
CH 2 CH(CH 3 ) 2
H
Ph
815.
CH 3
H
CH 2 CH(CH 3 ) 2
CH 3
Ph
816.
H
CH 3
CH 2 CH(CH 3 ) 2
CH 3
Ph
817.
CH 3
CH 3
CH 2 CH(CH 3 ) 2
CH 3
Ph
818.
C(CH 3 ) 3
H
H
H
Ph
819.
C(CH 3 ) 3
CH 3
H
CH 3
Ph
820.
C(CH 3 ) 3
H
CH 3
H
Ph
821.
C(CH 3 ) 3
H
H
CH 3
Ph
822.
C(CH 3 ) 3
CH 3
CH 3
H
Ph
823.
C(CH 3 ) 3
CH 3
H
CH 3
Ph
824.
C(CH 3 ) 3
H
CH 3
CH 3
Ph
825.
C(CH 3 ) 3
CH 3
CH 3
CH 3
Ph
826.
H
C(CH 3 ) 3
H
H
Ph
827.
CH 3
C(CH 3 ) 3
H
CH 3
Ph
828.
H
C(CH 3 ) 3
CH 3
H
Ph
829.
H
C(CH 3 ) 3
H
CH 3
Ph
830.
CH 3
C(CH 3 ) 3
CH 3
H
Ph
831.
CH 3
C(CH 3 ) 3
H
CH 3
Ph
832.
H
C(CH 3 ) 3
CH 3
CH 3
Ph
833.
CH 3
C(CH 3 ) 3
CH 3
CH 3
Ph
834.
H
H
C(CH 3 ) 3
H
Ph
835.
CH 3
H
C(CH 3 ) 3
H
Ph
836.
H
CH 3
C(CH 3 ) 3
H
Ph
837.
H
H
C(CH 3 ) 3
CH 3
Ph
838.
CH 3
CH 3
C(CH 3 ) 3
H
Ph
839.
CH 3
H
C(CH 3 ) 3
CH 3
Ph
840.
H
CH 3
C(CH 3 ) 3
CH 3
Ph
841.
CH 3
CH 3
C(CH3)3
CH 3
Ph
842.
CH 2 C(CH 3 ) 3
H
H
H
Ph
843.
CH 2 C(CH 3 ) 3
CH 3
H
CH 3
Ph
844.
CH 2 C(CH 3 ) 3
H
CH 3
H
Ph
845.
CH 2 C(CH 3 ) 3
H
H
CH 3
Ph
846.
CH 2 C(CH 3 ) 3
CH 3
CH 3
H
Ph
847.
CH 2 C(CH 3 ) 3
CH 3
H
CH 3
Ph
848.
CH 2 C(CH 3 ) 3
H
CH 3
CH 3
Ph
849.
CH 2 C(CH 3 ) 3
CH 3
CH 3
CH 3
Ph
850.
H
CH 2 C(CH 3 ) 3
H
H
Ph
851.
CH 3
CH 2 C(CH 3 ) 3
H
CH 3
Ph
852.
H
CH 2 C(CH 3 ) 3
CH 3
H
Ph
853.
H
CH 2 C(CH 3 ) 3
H
CH 3
Ph
854.
CH 3
CH 2 C(CH 3 ) 3
CH 3
H
Ph
855.
CH 3
CH 2 C(CH 3 ) 3
H
CH 3
Ph
856.
H
CH 2 C(CH 3 ) 3
CH 3
CH 3
Ph
857.
CH 3
CH 2 C(CH 3 ) 3
CH 3
CH 3
Ph
858.
H
H
CH 2 C(CH 3 ) 3
H
Ph
859.
CH 3
H
CH 2 C(CH 3 ) 3
H
Ph
860.
H
CH 3
CH 2 C(CH 3 ) 3
H
Ph
861.
H
H
CH 2 C(CH 3 ) 3
CH 3
Ph
862.
CH 3
CH 3
CH 2 C(CH 3 ) 3
H
Ph
863.
CH 3
H
CH 2 C(CH 3 ) 3
CH 3
Ph
864.
H
CH 3
CH 2 C(CH 3 ) 3
CH 3
Ph
865.
CH 3
CH 3
CH 2 C(CH 3 ) 3
CH 3
Ph
866.
H
H
H
Ph
867.
CH 3
H
CH 3
Ph
868.
H
CH 3
H
Ph
869.
H
H
CH 3
Ph
870.
CH 3
CH 3
H
Ph
871.
CH 3
H
CH 3
Ph
872.
H
CH 3
CH 3
Ph
873.
CH 3
CH 3
CH 3
Ph
874.
H
H
H
Ph
875.
CH 3
H
CH 3
Ph
876.
H
CH 3
H
Ph
877.
H
H
CH 3
Ph
878.
CH 3
CH 3
H
Ph
879.
CH 3
H
CH 3
Ph
880.
H
CH 3
CH 3
Ph
881.
CH 3
CH 3
CH 3
Ph
882.
H
H
H
Ph
883.
CH 3
H
H
Ph
884.
H
CH 3
H
Ph
885.
H
H
CH 3
Ph
886.
CH 3
CH 3
H
Ph
887.
CH 3
H
CH 3
Ph
888.
H
CH 3
CH 3
Ph
889.
CH 3
CH 3
CH 3
Ph
890.
H
H
H
Ph
891.
CH 3
H
CH 3
Ph
892.
H
CH 3
H
Ph
893.
H
H
CH 3
Ph
894.
CH 3
CH 3
H
Ph
895.
CH 3
H
CH 3
Ph
896.
H
CH 3
CH 3
Ph
897.
CH 3
CH 3
CH 3
Ph
898.
H
H
H
Ph
899.
CH 3
H
CH 3
Ph
900.
H
CH 3
H
Ph
901.
H
H
CH 3
Ph
902.
CH 3
CH 3
H
Ph
903.
CH 3
H
CH 3
Ph
904.
H
CH 3
CH 3
Ph
905.
CH 3
CH 3
CH 3
Ph
906.
H
H
H
Ph
907.
CH 3
H
H
Ph
908.
H
CH 3
H
Ph
909.
H
H
CH 3
Ph
910.
CH 3
CH 3
H
Ph
911.
CH 3
H
CH 3
Ph
912.
H
CH 3
CH 3
Ph
913.
CH 3
CH 3
CH 3
Ph
914.
H
H
H
Ph
915.
CH 3
H
CH 3
Ph
916.
H
CH 3
H
Ph
917.
H
H
CH 3
Ph
918.
CH 3
CH 3
H
Ph
919.
CH 3
H
CH 3
Ph
920.
H
CH 3
CH 3
Ph
921.
CH 3
CH 3
CH 3
Ph
922.
H
H
H
Ph
923.
CH 3
H
CH 3
Ph
924.
H
CH 3
H
Ph
925.
H
H
CH 3
Ph
926.
CH 3
CH 3
H
Ph
927.
CH 3
H
CH 3
Ph
928.
H
CH 3
CH 3
Ph
929.
CH 3
CH 3
CH 3
Ph
930.
H
H
H
Ph
931.
CH 3
H
H
Ph
932.
H
CH 3
H
Ph
933.
H
H
CH 3
Ph
934.
CH 3
CH 3
H
Ph
935.
CH 3
H
CH 3
Ph
936.
H
CH 3
CH 3
Ph
937.
CH 3
CH 3
CH 3
Ph
938.
H
H
H
Ph
939.
CH 3
H
CH 3
Ph
940.
H
CH 3
H
Ph
941.
H
H
CH 3
Ph
942.
CH 3
CH 3
H
Ph
943.
CH 3
H
CH 3
Ph
944.
H
CH 3
CH 3
Ph
945.
CH 3
CH 3
CH 3
Ph
946.
H
H
H
Ph
947.
CH 3
H
CH 3
Ph
948.
H
CH 3
H
Ph
949.
H
H
CH 3
Ph
950.
CH 3
CH 3
H
Ph
951.
CH 3
H
CH 3
Ph
952.
H
CH 3
CH 3
Ph
953.
CH 3
CH 3
CH 3
Ph
954.
H
H
H
Ph
955.
CH 3
H
H
Ph
956.
H
CH 3
H
Ph
957.
H
H
CH 3
Ph
958.
CH 3
CH 3
H
Ph
959.
CH 3
H
CH 3
Ph
960.
H
CH 3
CH 3
Ph
961.
CH 3
CH 3
CH 3
Ph
962.
H
H
H
Ph
963.
CH 3
H
CH 3
Ph
964.
H
CH 3
H
Ph
965.
H
H
CH 3
Ph
966.
CH 3
CH 3
H
Ph
967.
CH 3
H
CH 3
Ph
968.
H
CH 3
CH 3
Ph
969.
CH 3
CH 3
CH 3
Ph
970.
H
H
H
Ph
971.
CH 3
H
CH 3
Ph
972.
H
CH 3
H
Ph
973.
H
H
CH 3
Ph
974.
CH 3
CH 3
H
Ph
975.
CH 3
H
CH 3
Ph
976.
H
CH 3
CH 3
Ph
977.
CH 3
CH 3
CH 3
Ph
978.
H
H
H
Ph
979.
CH 3
H
H
Ph
980.
H
CH 3
H
Ph
981.
H
H
CH 3
Ph
982.
CH 3
CH 3
H
Ph
983.
CH 3
H
CH 3
Ph
984.
H
CH 3
CH 3
Ph
985.
CH 3
CH 3
CH 3
Ph
986.
H
H
H
Ph
987.
CH 3
H
CH 3
Ph
988.
H
CH 3
H
Ph
989.
H
H
CH 3
Ph
990.
CH 3
CH 3
H
Ph
991.
CH 3
H
CH 3
Ph
992.
H
CH 3
CH 3
Ph
993.
CH 3
CH 3
CH 3
Ph
994.
H
H
H
Ph
995.
CH 3
H
CH 3
Ph
996.
H
CH 3
H
Ph
997.
H
H
CH 3
Ph
998.
CH 3
CH 3
H
Ph
999.
CH 3
H
CH 3
Ph
1000.
H
CH 3
CH 3
Ph
1001.
CH 3
CH 3
CH 3
Ph
1002.
H
H
H
Ph
1003.
CH 3
H
H
Ph
1004.
H
CH 3
H
Ph
1005.
H
H
CH 3
Ph
1006.
CH 3
CH 3
H
Ph
1007.
CH 3
H
CH 3
Ph
1008.
H
CH 3
CH 3
Ph
1009.
CH 3
CH 3
CH 3
Ph
1010.
CH(CH 3 ) 2
H
CH 2 CH 3
H
Ph
1011.
CH(CH 3 ) 2
H
CH(CH 3 ) 2
H
Ph
1012.
CH(CH 3 ) 2
H
CH 2 CH(CH 3 ) 2
H
Ph
1013.
CH(CH 3 ) 2
H
C(CH 3 ) 3
H
Ph
1014.
CH(CH 3 ) 2
H
CH 2 C(CH 3 ) 3
H
Ph
1015.
CH(CH 3 ) 2
H
H
Ph
1016.
CH(CH 3 ) 2
H
H
Ph
1017.
CH(CH 3 ) 2
H
H
Ph
1018.
CH(CH 3 ) 2
H
H
Ph
1019.
CH(CH 3 ) 2
H
H
Ph
1020.
CH(CH 3 ) 2
H
H
Ph
1021.
C(CH 3 ) 3
H
CH 2 CH 3
H
Ph
1022.
C(CH 3 ) 3
H
CH(CH 3 ) 2
H
Ph
1023.
C(CH 3 ) 3
H
CH 2 CH(CH 3 ) 2
H
Ph
1024.
C(CH 3 ) 3
H
C(CH 3 ) 3
H
Ph
1025.
C(CH 3 ) 3
H
CH 2 C(CH 3 ) 3
H
Ph
1026.
C(CH 3 ) 3
H
H
Ph
1027.
C(CH 3 ) 3
H
H
Ph
1028.
C(CH 3 ) 3
H
H
Ph
1029.
C(CH 3 ) 3
H
H
Ph
1030.
C(CH 3 ) 3
H
H
Ph
1031.
C(CH 3 ) 3
H
H
Ph
1032.
CH 2 C(CH 3 ) 3
H
CH 2 CH 3
H
Ph
1033.
CH 2 C(CH 3 ) 3
H
CH(CH 3 ) 2
H
Ph
1034.
CH 2 C(CH 3 ) 3
H
CH 2 CH(CH 3 ) 2
H
Ph
1035.
CH 2 C(CH 3 ) 3
H
C(CH 3 ) 3
H
Ph
1036.
CH 2 C(CH 3 ) 3
H
CH 2 C(CH 3 ) 3
H
Ph
1037.
CH 2 C(CH 3 ) 3
H
H
Ph
1038.
CH 2 C(CH 3 ) 3
H
H
Ph
1039.
CH 2 C(CH 3 ) 3
H
H
Ph
1040.
CH 2 C(CH 3 ) 3
H
H
Ph
1041.
CH 2 C(CH 3 ) 3
H
H
Ph
1042.
CH 2 C(CH 3 ) 3
H
H
Ph
1043.
H
CH 2 CH 3
H
Ph
1044.
H
CH(CH 3 ) 2
H
Ph
1045.
H
CH 2 CH(CH 3 ) 2
H
Ph
1046.
H
C(CH 3 ) 3
H
Ph
1047.
H
CH 2 C(CH 3 ) 3
H
Ph
1048.
H
H
Ph
1049.
H
H
Ph
1050.
H
H
Ph
1051.
H
H
Ph
1052.
H
H
Ph
1053.
H
H
Ph
1054.
H
CH 2 CH 3
H
Ph
1055.
H
CH(CH3)2
H
Ph
1056.
H
CH 2 CH(CH 3 ) 2
H
Ph
1057.
H
C(CH 3 ) 3
H
Ph
1058.
H
CH 2 C(CH 3 ) 3
H
Ph
1059.
H
H
Ph
1060.
H
H
Ph
1061.
H
H
Ph
1062.
H
H
Ph
1063.
H
H
Ph
1064.
H
H
Ph
1065.
H
CH 2 CH(CH 3 ) 2
H
Ph
1066.
H
C(CH 3 ) 3
H
Ph
1067.
H
CH 2 C(CH 3 ) 3
H
Ph
1068.
H
H
Ph
1069.
H
H
Ph
1070.
H
H
Ph
1071.
H
H
Ph
1072.
H
H
Ph
1073.
H
H
Ph
1074.
H
CH 2 CH(CH 3 ) 2
H
Ph
1075.
H
C(CH 3 ) 3
H
Ph
1076.
H
CH 2 C(CH 3 ) 3
H
Ph
1077.
H
H
Ph
1078.
H
H
Ph
1079.
H
H
Ph
1080.
H
H
Ph
1081.
H
H
Ph
1082.
H
H
Ph
1083.
H
CH 2 CH(CH 3 ) 2
H
Ph
1084.
H
C(CH 3 ) 3
H
Ph
1085.
H
CH 2 C(CH 3 ) 3
H
Ph
1086.
H
H
Ph
1087.
H
H
Ph
1088.
H
H
Ph
1089.
H
H
Ph
1090.
H
H
Ph
1091.
H
H
Ph
1092.
H
H
H
H
Ph
1093.
CD 3
H
H
H
Ph
1094.
H
CD 3
H
H
Ph
1095.
H
H
CD 3
H
Ph
1096.
CD 3
CD 3
H
CD 3
Ph
1097.
CD 3
H
CD 3
H
Ph
1098.
CD 3
H
H
CD 3
Ph
1099.
H
CD 3
CD 3
H
Ph
1100.
H
CD 3
H
CD 3
Ph
1101.
H
H
CD 3
CD 3
Ph
1102.
CD 3
CD 3
CD 3
H
Ph
1103.
CD 3
CD 3
H
CD 3
Ph
1104.
CD 3
H
CD 3
CD 3
Ph
1105.
H
CD 3
CD 3
CD 3
Ph
1106.
CD 3
CD 3
CD 3
CD 3
Ph
1107.
CD 2 CH 3
H
H
H
Ph
1108.
CD 2 CH 3
CD 3
H
CD 3
Ph
1109.
CD 2 CH 3
H
CD 3
H
Ph
1110.
CD 2 CH 3
H
H
CD 3
Ph
1111.
CD 2 CH 3
CD 3
CD 3
H
Ph
1112.
CD 2 CH 3
CD 3
H
CD 3
Ph
1113.
CD 2 CH 3
H
CD 3
CD 3
Ph
1114.
CD 2 CH 3
CD 3
CD 3
CD 3
Ph
1115.
H
CD 2 CH 3
H
H
Ph
1116.
CH 3
CD 2 CH 3
H
CD 3
Ph
1117.
H
CD 2 CH 3
CD 3
H
Ph
1118.
H
CD 2 CH 3
H
CD 3
Ph
1119.
CD 3
CD 2 CH 3
CD 3
H
Ph
1120.
CD 3
CD 2 CH 3
H
CD 3
Ph
1121.
H
CD 2 CH 3
CD 3
CD 3
Ph
1122.
CD 3
CD 2 CH 3
CD 3
CD 3
Ph
1123.
H
H
CD 2 CH 3
H
Ph
1124.
CD 3
H
CD 2 CH 3
H
Ph
1125.
H
CD 3
CD 2 CH 3
H
Ph
1126.
H
H
CD 2 CH 3
CD 3
Ph
1127.
CD 3
CD 3
CD 2 CH 3
H
Ph
1128.
CD 3
H
CD 2 CH 3
CD 3
Ph
1129.
H
CD 3
CD 2 CH 3
CD 3
Ph
1130.
CD 3
CD 3
CD 2 CH 3
CD 3
Ph
1131.
CD(CH 3 ) 2
H
H
H
Ph
1132.
CD(CH 3 ) 2
CD 3
H
CD 3
Ph
1133.
CD(CH 3 ) 2
H
CD 3
H
Ph
1134.
CD(CH 3 ) 2
H
H
CD 3
Ph
1135.
CD(CH 3 ) 2
CD 3
CD 3
H
Ph
1136.
CD(CH 3 ) 2
CD 3
H
CD 3
Ph
1137.
CD(CH 3 ) 2
H
CD 3
CD 3
Ph
1138.
CD(CH 3 ) 2
CD 3
CD 3
CD 3
Ph
1139.
H
CD(CH 3 ) 2
H
H
Ph
1140.
CD 3
CD(CH 3 ) 2
H
CD 3
Ph
1141.
H
CD(CH 3 ) 2
CD 3
H
Ph
1142.
H
CD(CH 3 ) 2
H
CD 3
Ph
1143.
CD 3
CD(CH 3 ) 2
CD 3
H
Ph
1144.
CD 3
CD(CH 3 ) 2
H
CD 3
Ph
1145.
H
CD(CH 3 ) 2
CD 3
CD 3
Ph
1146.
CD 3
CD(CH 3 ) 2
CD 3
CD 3
Ph
1147.
H
H
CD(CH 3 ) 2
H
Ph
1148.
CD 3
H
CD(CH 3 ) 2
H
Ph
1149.
H
CD 3
CD(CH 3 ) 2
H
Ph
1150.
H
H
CD(CH 3 ) 2
CD 3
Ph
1151.
CD 3
CD 3
CD(CH 3 ) 2
H
Ph
1152.
CD 3
H
CD(CH 3 ) 2
CD 3
Ph
1153.
H
CD 3
CD(CH 3 ) 2
CD 3
Ph
1154.
CD 3
CD 3
CD(CH 3 ) 2
CD 3
Ph
1155.
CD(CD 3 ) 2
H
H
H
Ph
1156.
CD(CD 3 ) 2
CD 3
H
CD 3
Ph
1157.
CD(CD 3 ) 2
H
CD 3
H
Ph
1158.
CD(CD 3 ) 2
H
H
CD 3
Ph
1159.
CD(CD 3 ) 2
CD 3
CD 3
H
Ph
1160.
CD(CD 3 ) 2
CD 3
H
CD 3
Ph
1161.
CD(CD 3 ) 2
H
CD 3
CD 3
Ph
1162.
CD(CD 3 ) 2
CD 3
CD 3
CD 3
Ph
1163.
H
CD(CD 3 ) 2
H
H
Ph
1164.
CH 3
CD(CD 3 ) 2
H
CD 3
Ph
1165.
H
CD(CD 3 ) 2
CD 3
H
Ph
1166.
H
CD(CD 3 ) 2
H
CD 3
Ph
1167.
CD 3
CD(CD 3 ) 2
CD 3
H
Ph
1168.
CD 3
CD(CD 3 ) 2
H
CD 3
Ph
1169.
H
CD(CD 3 ) 2
CD 3
CD 3
Ph
1170.
CD 3
CD(CD 3 ) 2
CD 3
CD 3
Ph
1171.
H
H
CD(CD 3 ) 2
H
Ph
1172.
CD 3
H
CD(CD 3 ) 2
H
Ph
1173.
H
CD 3
CD(CD 3 ) 2
H
Ph
1174.
H
H
CD(CD 3 ) 2
CD 3
Ph
1175.
CD 3
CD 3
CD(CD 3 ) 2
H
Ph
1176.
CD 3
H
CD(CD 3 ) 2
CD 3
Ph
1177.
H
CD 3
CD(CD 3 ) 2
CD 3
Ph
1178.
CD 3
CD 3
CD(CD 3 ) 2
CD 3
Ph
1179.
CD 2 CH(CH 3 ) 2
H
H
H
Ph
1180.
CD 2 CH(CH 3 ) 2
CD 3
H
CD 3
Ph
1181.
CD 2 CH(CH 3 ) 2
H
CD 3
H
Ph
1182.
CD 2 CH(CH 3 ) 2
H
H
CD 3
Ph
1183.
CD 2 CH(CH 3 ) 2
CD 3
CD 3
H
Ph
1184.
CD 2 CH(CH 3 )2
CD 3
H
CD 3
Ph
1185.
CD 2 CH(CH 3 ) 2
H
CD 3
CD 3
Ph
1186.
CD 2 CH(CH 3 ) 2
CD 3
CD 3
CD 3
Ph
1187.
H
CD 2 CH(CH 3 ) 2
H
H
Ph
1188.
CD 3
CD 2 CH(CH 3 ) 2
H
CD 3
Ph
1189.
H
CD 2 CH(CH 3 ) 2
CD 3
H
Ph
1190.
H
CD 2 CH(CH 3 ) 2
H
CD 3
Ph
1191.
CD 3
CD 2 CH(CH 3 ) 2
CD 3
H
Ph
1192.
CD 3
CD 2 CH(CH 3 ) 2
H
CD 3
Ph
1193.
H
CD 2 CH(CH 3 ) 2
CD 3
CD 3
Ph
1194.
CD 3
CD 2 CH(CH 3 ) 2
CD 3
CD 3
Ph
1195.
H
H
CD 2 CH(CH 3 ) 2
H
Ph
1196.
CD 3
H
CD 2 CH(CH 3 ) 2
H
Ph
1197.
H
CD 3
CD 2 CH(CH 3 ) 2
H
Ph
1198.
H
H
CD 2 CH(CH 3 ) 2
CD 3
Ph
1199.
CD 3
CD 3
CD 2 CH(CH 3 ) 2
H
Ph
1200.
CD 3
H
CD 2 CH(CH 3 ) 2
CD 3
Ph
1201.
H
CD 3
CD 2 CH(CH 3 ) 2
CD 3
Ph
1202.
CD 3
CD 3
CD 2 CH(CH 3 ) 2
CD 3
Ph
1203.
CD 2 C(CH 3 ) 3
H
H
H
Ph
1204.
CD 2 C(CH 3 ) 3
CD 3
H
CD 3
Ph
1205.
CD 2 C(CH 3 ) 3
H
CD 3
H
Ph
1206.
CD 2 C(CH 3 ) 3
H
H
CD 3
Ph
1207.
CD 2 C(CH 3 ) 3
CD 3
CD 3
H
Ph
1208.
CD 2 C(CH 3 ) 3
CD 3
H
CD 3
Ph
1209.
CD 2 C(CH 3 ) 3
H
CD 3
CD 3
Ph
1210.
CD 2 C(CH 3 ) 3
CH 3
CD 3
CD 3
Ph
1211.
H
CD 2 C(CH 3 ) 3
H
H
Ph
1212.
CD 3
CD 2 C(CH3) 3
H
CD 3
Ph
1213.
H
CD 2 C(CH 3 ) 3
CD 3
H
Ph
1214.
H
CD 2 C(CH 3 ) 3
H
CD 3
Ph
1215.
CD 3
CD 2 C(CH 3 ) 3
CD 3
H
Ph
1216.
CD 3
CD 2 C(CH 3 ) 3
H
CD 3
Ph
1217.
H
CD 2 C(CH 3 ) 3
CD 3
CD 3
Ph
1218.
CD 3
CD 2 C(CH 3 ) 3
CD 3
CD 3
Ph
1219.
H
H
CD 2 C(CH 3 ) 3
H
Ph
1220.
CD 3
H
CD 2 C(CH 3 ) 3
H
Ph
1221.
H
CD 3
CD 2 C(CH 3 ) 3
H
Ph
1222.
H
H
CD 2 C(CH 3 ) 3
CD 3
Ph
1223.
CD 3
CD 3
CD 2 C(CH 3 ) 3
H
Ph
1224.
CD 3
H
CD 2 C(CH 3 ) 3
CD 3
Ph
1225.
H
CD 3
CD 2 C(CH 3 ) 3
CD 3
Ph
1226.
CD 3
CD 3
CD 2 C(CH 3 ) 3
CD 3
Ph
1227.
H
H
H
Ph
1228.
CD 3
H
CD 3
Ph
1229.
H
CD 3
H
Ph
1230.
H
H
CD 3
Ph
1231.
CD 3
CD 3
H
Ph
1232.
CD 3
H
CD 3
Ph
1233.
H
CD 3
CD 3
Ph
1234.
CD 3
CD 3
CD 3
Ph
1235.
H
H
H
Ph
1236.
CD 3
H
CD 3
Ph
1237.
H
CD 3
H
Ph
1238.
H
H
CD 3
Ph
1239.
CD 3
CD 3
H
Ph
1240.
CD 3
H
CD 3
Ph
1241.
H
CD 3
CD 3
Ph
1242.
CD 3
CD 3
CD 3
Ph
1243.
H
H
H
Ph
1244.
CD 3
H
H
Ph
1245.
H
CD 3
H
Ph
1246.
H
H
CD 3
Ph
1247.
CD 3
CD 3
H
Ph
1248.
CD 3
H
CD 3
Ph
1249.
H
CD 3
CD 3
Ph
1250.
CD 3
CD 3
CD 3
Ph
1251.
H
H
H
Ph
1252.
CD 3
H
CD 3
Ph
1253.
H
CD 3
H
Ph
1254.
H
H
CD 3
Ph
1255.
CD 3
CD 3
H
Ph
1256.
CD 3
H
CD 3
Ph
1257.
H
CD 3
CD 3
Ph
1258.
CD 3
CD 3
CD 3
Ph
1259.
H
H
H
Ph
1260.
CH 3
H
CD 3
Ph
1261.
H
CD 3
H
Ph
1262.
H
H
CD 3
Ph
1263.
CD 3
CD 3
H
Ph
1264.
CD 3
H
CD 3
Ph
1265.
H
CD 3
CD 3
Ph
1266.
CH 3
CD 3
CD 3
Ph
1267.
H
H
H
Ph
1268.
CD 3
H
H
Ph
1269.
H
CD 3
H
Ph
1270.
H
H
CD 3
Ph
1271.
CD 3
CD 3
H
Ph
1272.
CD 3
H
CD 3
Ph
1273.
H
CD 3
CD 3
Ph
1274.
CD 3
CD 3
CD 3
Ph
1275.
H
H
H
Ph
1276.
CD 3
H
CD 3
Ph
1277.
H
CD 3
H
Ph
1278.
H
H
CD 3
Ph
1279.
CD 3
CD 3
H
Ph
1280.
CD 3
H
CD 3
Ph
1281.
H
CD 3
CD 3
Ph
1282.
CD 3
CD 3
CD 3
Ph
1283.
H
H
H
Ph
1284.
CD 3
H
CD 3
Ph
1285.
H
CD 3
H
Ph
1286.
H
H
CD 3
Ph
1287.
CD 3
CD 3
H
Ph
1288.
CD 3
H
CD 3
Ph
1289.
H
CD 3
CD 3
Ph
1290.
CD 3
CD 3
CD 3
Ph
1291.
H
H
H
Ph
1292.
CD 3
H
H
Ph
1293.
H
CD 3
H
Ph
1294.
H
H
CD 3
Ph
1295.
CD 3
CD 3
H
Ph
1296.
CD 3
H
CD 3
Ph
1297.
H
CD 3
CD 3
Ph
1298.
CD 3
CD 3
CD 3
Ph
1299.
H
H
H
Ph
1300.
CD 3
H
CD 3
Ph
1301.
H
CD 3
H
Ph
1302.
H
H
CD 3
Ph
1303.
CD 3
CD 3
H
Ph
1304.
CD 3
H
CD 3
Ph
1305.
H
CD 3
CD 3
Ph
1306.
CD 3
CD 3
CD 3
Ph
1307.
H
H
H
Ph
1308.
CD 3
H
CD 3
Ph
1309.
H
CD 3
H
Ph
1310.
H
H
CD 3
Ph
1311.
CD 3
CD 3
H
Ph
1312.
CD 3
H
CD 3
Ph
1313.
H
CD 3
CD 3
Ph
1314.
CD 3
CD 3
CD 3
Ph
1315.
H
H
H
Ph
1316.
CD 3
H
H
Ph
1317.
H
CD 3
H
Ph
1318.
H
H
CD 3
Ph
1319.
CD 3
CD 3
H
Ph
1320.
CD 3
H
CD 3
Ph
1321.
H
CD 3
CD 3
Ph
1322.
CD 3
CD 3
CD 3
Ph
1323.
H
H
H
Ph
1324.
CD 3
H
CD 3
Ph
1325.
H
CD 3
H
Ph
1326.
H
H
CD 3
Ph
1327.
CD 3
CD 3
H
Ph
1328.
CD 3
H
CD 3
Ph
1329.
H
CD 3
CD 3
Ph
1330.
CD 3
CD 3
CD 3
Ph
1331.
H
H
H
Ph
1332.
CD 3
H
CD 3
Ph
1333.
H
CD 3
H
Ph
1334.
H
H
CD 3
Ph
1335.
CD 3
CD 3
H
Ph
1336.
CD 3
H
CD 3
Ph
1337.
H
CD 3
CD 3
Ph
1338.
CD 3
CD 3
CD 3
Ph
1339.
H
H
H
Ph
1340.
CD 3
H
H
Ph
1341.
H
CD 3
H
Ph
1342.
H
H
CD 3
Ph
1343.
CD 3
CD 3
H
Ph
1344.
CD 3
H
CD 3
Ph
1345.
H
CD 3
CD 3
Ph
1346.
CD 3
CD 3
CD 3
Ph
1347.
H
H
H
Ph
1348.
CD 3
H
CD 3
Ph
1349.
H
CD 3
H
Ph
1350.
H
H
CD 3
Ph
1351.
CH 3
CH 3
H
Ph
1352.
CD 3
H
CD 3
Ph
1353.
H
CD 3
CD 3
Ph
1354.
CD 3
CD 3
CD 3
Ph
1355.
H
H
H
Ph
1356.
CD 3
H
CD 3
Ph
1357.
H
CD 3
H
Ph
1358.
H
H
CD 3
Ph
1359.
CD 3
CD 3
H
Ph
1360.
CD 3
H
CD 3
Ph
1361.
H
CD 3
CD 3
Ph
1362.
CD 3
CD 3
CD 3
Ph
1363.
H
H
H
Ph
1364.
CD 3
H
H
Ph
1365.
H
CD 3
H
Ph
1366.
H
H
CD 3
Ph
1367.
CD 3
CD 3
H
Ph
1368.
CD 3
H
CD 3
Ph
1369.
H
CD 3
CD 3
Ph
1370.
CD 3
CD 3
CD 3
Ph
1371.
CD(CH 3 ) 2
H
CD 2 CH 3
H
Ph
1372.
CD(CH 3 ) 2
H
CD(CH 3 ) 2
H
Ph
1373.
CD(CH 3 ) 2
H
CD 2 CH(CH 3 ) 2
H
Ph
1374.
CD(CH 3 ) 2
H
C(CH 3 ) 3
H
Ph
1375.
CD(CH 3 ) 2
H
CD 2 C(CH 3 ) 3
H
Ph
1376.
CD(CH 3 ) 2
H
H
Ph
1377.
CD(CH 3 ) 2
H
H
Ph
1378.
CD(CH3)2
H
H
Ph
1379.
CD(CH 3 ) 2
H
H
Ph
1380.
CD(CH 3 ) 2
H
H
Ph
1381.
CD(CH 3 ) 2
H
H
Ph
1382.
C(CH 3 ) 3
H
CD 2 CH 3
H
Ph
1383.
C(CH 3 ) 3
H
CD(CH 3 ) 2
H
Ph
1384.
C(CH 3 ) 3
H
CD 2 CH(CH 3 ) 2
H
Ph
1385.
C(CH 3 ) 3
H
C(CH 3 ) 3
H
Ph
1386.
C(CH 3 ) 3
H
CD 2 C(CH 3 ) 3
H
Ph
1387.
C(CH 3 ) 3
H
H
Ph
1388.
C(CH 3 ) 3
H
H
Ph
1389.
C(CH 3 ) 3
H
H
Ph
1390.
C(CH 3 ) 3
H
H
Ph
1391.
C(CH 3 ) 3
H
H
Ph
1392.
C(CH 3 ) 3
H
H
Ph
1393.
CD 2 C(CH 3 ) 3
H
CD 2 CH 3
H
Ph
1394.
CD 2 C(CH 3 ) 3
H
CD(CH 3 ) 2
H
Ph
1395.
CD 2 C(CH 3 ) 3
H
CD 2 CH(CH 3 ) 2
H
Ph
1396.
CD 2 C(CH 3 ) 3
H
C(CH 3 ) 3
H
Ph
1397.
CD 2 C(CH 3 ) 3
H
CD 2 C(CH 3 ) 3
H
Ph
1398.
CD 2 C(CH 3 ) 3
H
H
Ph
1399.
CD 2 C(CH 3 ) 3
H
H
Ph
1400.
CD 2 C(CH 3 ) 3
H
H
Ph
1401.
CD 2 C(CH 3 ) 3
H
H
Ph
1402.
CD 2 C(CH 3 ) 3
H
H
Ph
1403.
CD 2 C(CH 3 ) 3
H
H
Ph
1404.
H
CD 2 CH 3
H
Ph
1405.
H
CD(CH 3 ) 2
H
Ph
1406.
H
CD 2 CH(CH 3 ) 2
H
Ph
1407.
H
C(CH 3 ) 3
H
Ph
1408.
H
CD 2 C(CH 3 ) 3
H
Ph
1409.
H
H
Ph
1410.
H
H
Ph
1411.
H
H
Ph
1412.
H
H
Ph
1413.
H
H
Ph
1414.
H
H
Ph
1415.
H
CD 2 CH 3
H
Ph
1416.
H
CD(CH 3 ) 2
H
Ph
1417.
H
CD 2 CH(CH 3 ) 2
H
Ph
1418.
H
C(CH 3 ) 3
H
Ph
1419.
H
CD 2 C(CH 3 ) 3
H
Ph
1420.
H
H
Ph
1421.
H
H
Ph
1422.
H
H
Ph
1423.
H
H
Ph
1424.
H
H
Ph
1425.
H
H
Ph
1426.
H
CD 2 CH 3
H
Ph
1427.
H
CD(CH 3 ) 2
H
Ph
1428.
H
CD 2 CH(CH 3 ) 2
H
Ph
1429.
H
C(CH 3 ) 3
H
Ph
1430.
H
CD 2 C(CH 3 ) 3
H
Ph
1431.
H
H
Ph
1432.
H
H
Ph
1433.
H
H
Ph
1434.
H
H
Ph
1435.
H
H
Ph
1436.
H
H
Ph
1437.
H
CD 2 CH 3
H
Ph
1438.
H
CD(CH 3 ) 2
H
Ph
1439.
H
CD 2 CH(CH 3 ) 2
H
Ph
1440.
H
C(CH 3 ) 3
H
Ph
1441.
H
CD 2 C(CH 3 ) 3
H
Ph
1442.
H
H
Ph
1443.
H
H
Ph
1444.
H
H
Ph
1445.
H
H
Ph
1446.
H
H
Ph
1447.
H
H
Ph
1448.
H
CD 2 CH 3
H
Ph
1449.
H
CD(CH 3 ) 2
H
Ph
1450.
H
CD 2 CH(CH 3 ) 2
H
Ph
1451.
H
C(CH 3 ) 3
H
Ph
1452.
H
CD 2 C(CH 3 ) 3
H
Ph
1453.
H
H
Ph
1454.
H
H
Ph
1455.
H
H
Ph
1456.
H
H
Ph
1457.
H
H
Ph
1458.
H
H
Ph
1459.
H
Ph
CD3
H
H
1460.
H
CD3
H
H
1461.
H
CD3
H
H
1462.
H
CD3
H
H
8. The compound of claim 7 , wherein the compound is selected from the group consisting of:
Compnd #
L A is
L B is
L C is
504
L b A8
L a A139
L 1
505
L b A10
L a A139
L 1
506
L b A12
L a A139
L 1
507
L b A16
L a A139
L 1
516
L b A88
L a A139
L 1
517
L b A94
L a A139
L 1
520
L b A177
L a A139
L 1
521
L b A178
L a A139
L 1
522
L b A179
L a A139
L 1
523
L b A180
L a A139
L 1
524
L b A181
L a A139
L 1
525
L b A182
L a A139
L 1
526
L b A183
L a A139
L 1
527
L b A184
L a A139
L 1
528
L b A185
L a A139
L 1
529
L b A186
L a A139
L 1
530
L b A187
L a A139
L 1
531
L b A188
L a A139
L 1
532
L b A189
L a A139
L 1
533
L b A190
L a A139
L 1
534
L b A191
L a A139
L 1
538
L b A8
L a A209
L 1
539
L b A10
L a A209
L 1
540
L b A12
L a A209
L 1
541
L b A16
L a A209
L 1
550
L b A88
L a A209
L 1
551
L b A94
L a A209
L 1
554
L b A177
L a A209
L 1
555
L b A178
L a A209
L 1
556
L b A179
L a A209
L 1
557
L b A180
L a A209
L 1
558
L b A181
L a A209
L 1
559
L b A182
L a A209
L 1
560
L b A183
L a A209
L 1
561
L b A184
L a A209
L 1
562
L b A185
L a A209
L 1
563
L b A186
L a A209
L 1
564
L b A187
L a A209
L 1
565
L b A188
L a A209
L 1
566
L b A189
L a A209
L 1
567
L b A190
L a A209
L 1
572
L b A8
L b A3
L 1
573
L b A10
L b A3
L 1
574
L b A12
L b A3
L 1
575
L b A16
L b A3
L 1
584
L b A88
L b A3
L 1
585
L b A94
L b A3
L 1
588
L b A177
L b A3
L 1
589
L b A178
L b A3
L 1
590
L b A179
L b A3
L 1
591
L b A180
L b A3
L 1
592
L b A181
L b A3
L 1
593
L b A182
L b A3
L 1
594
L b A183
L b A3
L 1
595
L b A184
L b A3
L 1
596
L b A185
L b A3
L 1
597
L b A186
L b A3
L 1
598
L b A187
L b A3
L 1
599
L b A188
L b A3
L 1
600
L b A189
L b A3
L 1
601
L b A190
L b A3
L 1
602
L b A191
L b A3
L 1
604
L c A8
L A A210
L 1
605
L c A10
L A A210
L 1
606
L c A12
L A A210
L 1
607
L c A16
L A A210
L 1
616
L c A88
L A A210
L 1
617
L c A94
L A A210
L 1
621
L c A177
L A A210
L 1
622
L c A178
L A A210
L 1
623
L c A179
L A A210
L 1
624
L c A180
L A A210
L 1
625
L c A181
L A A210
L 1
626
L c A182
L A A210
L 1
627
L c A183
L A A210
L 1
628
L c A184
L A A210
L 1
629
L c A185
L A A210
L 1
630
L c A186
L A A210
L 1
631
L c A187
L A A210
L 1
632
L c A188
L A A210
L 1
633
L c A189
L A A210
L 1
634
L c A190
L A A210
L 1
635
L c A191
L A A210
L 1
636
L c A192
L A A210
L 1
638
L c A8
L A A211
L 1
639
L c A10
L A A211
L 1
640
L c A12
L A A211
L 1
641
L c A16
L A A211
L 1
650
L c A88
L A A211
L 1
651
L c A94
L A A211
L 1
655
L c A177
L A A211
L 1
656
L c A178
L A A211
L 1
657
L c A179
L A A211
L 1
658
L c A180
L A A211
L 1
659
L c A181
L A A211
L 1
660
L c A182
L A A211
L 1
661
L c A183
L A A211
L 1
662
L c A184
L A A211
L 1
663
L c A185
L A A211
L 1
664
L c A186
L A A211
L 1
665
L c A187
L A A211
L 1
666
L c A188
L A A211
L 1
667
L c A189
L A A211
L 1
668
L c A190
L A A211
L 1
669
L c A191
L A A211
L 1
670
L c A192
L A A211
L 1 ,
and stereoisomers thereof.
9. The compound of claim 1 , wherein the compound is selected from the group consisting of:
R A and R A1 have the same definition as R 2 ;
R A2 has the same definition as R 3 ;
R B , R B1 , and R B2 have the same definition as R 1 ;
R C1 and R C2 have the same definition as R C ;
R D1 and R D2 have the same definition as R D .
10. The compound of claim 1 , wherein at least five of R 1 , R 2 , and R 2′ comprises a moiety selected from the group consisting of alkyl, cycloalkyl, aryl and heteroaryl.
11. The compound of claim 1 , wherein at least three of R 1 , R 2 , and R 2′ comprises alkyl, cycloalkyl, aryl, or heteroaryl, with at least one of R 1 , R 2 , and R 2′ comprising cycloalkyl, aryl, or heteroaryl.
12. The compound of claim 1 , wherein ligand L A is selected from the group consisting of:
13. An organic light emitting device (OLED) comprising:
an anode;
a cathode; and
an organic layer, disposed between the anode and the cathode, comprising a compound having a formula Ir(L A )(L B )(L C );
wherein the ligand L A and the ligand L B are each independently selected from the group consisting of:
wherein the ligand L C is
wherein rings C and D are each independently a 5 or 6-membered carbocyclic or heterocyclic ring;
wherein R 1 , R 1a , R 1b , R 2 , R 2′ , R 3 , R C , and R D each independently represents mono, to a maximum possible number of substitutions, or no substitution;
wherein X 1 to X 12 , Z 1 , and Z 2 are each independently C or N;
wherein Y 1 is selected from the group consisting of O, S, Se, and Ge;
wherein X is selected from the group consisting of BR′, NR′, PR′, O, S, Se, C═O, S═O, SO 2 , CR′R″, SiR′R″, and GeR′R″;
wherein L A , L B , and L C are different from each other, and can be connected to each other to form multidentate ligand;
wherein, when present, at least one substituent R 2′ comprises aryl or heteroaryl and can be further substituted by one or more moieties selected from the group consisting of deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof;
wherein R 1 , R 1a , R 1b , R 2 , R 2′ , R 3 , R A , R B , R C , R D , R′, and R″ are each independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof;
wherein any two or more substituents among possible ring forming substituents are optionally joined or fused into a ring;
wherein R 1a , R 1b , R 2 , R 2′ , R 3 , R A , R C , R D , R′, and R″ are possible ring forming substituents;
wherein (a) at least four of R 1 , R 2 , and R 2′ comprises a moiety selected from the group consisting of alkyl, cycloalkyl, aryl and heteroaryl,
(b) at least three of R 1 , R 2 , and R 2′ comprises alkyl, cycloalkyl, aryl, or heteroaryl, with at least one of R 1 , R 2 , and R 2′ comprising cycloalkyl, aryl, or heteroaryl,
(c)(i) L A and L B are both selected from the croup consisting of
(ii) at least three of R 1 , R 2 , and R 3 comprise alkyl, cycloalkyl, aryl, or heteroaryl, and (iii) exactly one of X 5 to X 10 is N, or at least one X is selected from the group consisting of BR′, NR′, PR′, Se, C═O, S═O, SO2, CR′R″, SiR′R″, or GeR′R″, or (d) any combination of (a), (b), or (c);
wherein:
if Z 1 is C or Ring B is a five-membered carbocyclic or heterocyclic ring, then R B is one of the possible ring forming substituents, and
if Z 1 is N, then (i) at least one R B comprises aryl or heteroaryl and the R B substituents are not joined or fused into a ring, or (ii) at least one R A or R B comprises cycloalkyl; and
wherein:
if Z 2 is C or Ring D is a five-membered carbocyclic or heterocyclic ring, then R D is one of the possible ring forming substituents, and
if Z 2 is N, then R D substituents are not joined or fused into a ring.
14. The OLED of claim 13 , wherein the organic layer is an emissive layer and the compound is an emissive dopant or a non-emissive dopant.
15. The OLED of claim 13 , wherein the organic layer further comprises a host, wherein the host comprises a triphenylene containing benzo-fused thiophene or benzo-fused furan;
wherein any substituent in the host is an unfused substituent independently selected from the group consisting of C n H 2n+1 , OC n H 2n+1 , OAr 1 , N(C n H 2n+1 ) 2 , N(Ar 1 )(Ar 2 ), CH═CH—C n H 2n+1 , C≡CC n H 2n+1 , Ar 1 , Ar 1 -Ar 2 , and C n H 2n -Ar 1 , or the host has no substitutions;
wherein n is from 1 to 10; and
wherein Ar 1 and Ar 2 are each independently selected from the group consisting of benzene, biphenyl, naphthalene, triphenylene, carbazole, and heteroaromatic analogs thereof.
16. The OLED of claim 13 , wherein the organic layer further comprises a host, wherein host comprises at least one chemical group selected from the group consisting of triphenylene, carbazole, dibenzothiophene, dibenzofuran, dibenzoselenophene, azatriphenylene, azacarbazole, aza-dibenzothiophene, aza-dibenzofuran, and aza-dibenzoselenophene.
17. The OLED of claim 13 , wherein the organic layer further comprises a host, wherein the host is selected from the group consisting of:
and combinations thereof.
18. The OLED of claim 13 , wherein the organic layer further comprises a host, wherein the host comprises a metal complex.
19. A consumer product comprising an organic light-emitting device (OLED) comprising:
an anode;
a cathode; and
an organic layer, disposed between the anode and the cathode, comprising a compound having a formula Ir(L A )(L B )(L C );
wherein the ligand L A and the ligand L B are each independently selected from the group consisting of:
wherein the ligand L C is
wherein rings C and D are each independently a 5 or 6-membered carbocyclic or heterocyclic ring;
wherein R 1 , R 1a , R 1b , R 2 , R 2′ , R 3 , R C , and R D each independently represents mono, to a maximum possible number of substitutions, or no substitution;
wherein X 1 to X 12 , Z 1 , and Z 2 are each independently C or N;
wherein Y 1 is selected from the group consisting of O, S, Se, and Ge;
wherein X is selected from the group consisting of BR′, NR′, PR′, O, S, Se, C═O, S═O, SO 2 , CR′R″, SiR′R″, and GeR′R″;
wherein L A , L B , and L C are different from each other, and can be connected to each other to form multidentate ligand;
wherein, when present, at least one substituent R 2′ comprises aryl or heteroaryl and can be further substituted by one or more moieties selected from the group consisting of deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof;
wherein R 1 , R 1a , R 1b , R 2 , R 2′ , R 3 , R A , R B , R C , R D , R′, and R″ are each independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof;
wherein any two or more substituents among possible ring forming substituents are optionally joined or fused into a ring;
wherein R 1a , R 1b , R 2 , R 2′ , R 3 , R A , R C , R D , R′, and R″ are possible ring forming substituents;
wherein (a) at least four of R 1 , R 2 , and R 2′ comprises a moiety selected from the group consisting of alkyl, cycloalkyl, aryl and heteroaryl,
(b) at least three of R 1 , R 2 , and R 2′ comprises alkyl, cycloalkyl, aryl, or heteroaryl, with at least one of R 1 , R 2 , and R 2′ comprising cycloalkyl, aryl, or heteroaryl,
(c)(i) L A and L B are both selected from the croup consisting of
(ii) at least three of R 1 , R 2 , and R 3 comprise alkyl, cycloalkyl, aryl, or heteroaryl, and (iii) exactly one of X 5 to X 10 is N, or at least one X is selected from the group consisting of BR′, NR′, PR′, Se, C═O, S═O, SO2, CR′R″, SiR′R″, or GeR′R″, or
(d) any combination of (a), (b), or (c);
wherein:
if Z 1 is C or Ring B is a five-membered carbocyclic or heterocyclic ring, then R B is one of the possible ring forming substituents, and
if Z 1 is N, then (i) at least one R B comprises aryl or heteroaryl and the R B substituents are not joined or fused into a ring, or (ii) at least one R A or R B comprises cycloalkyl; and
wherein:
if Z 2 is C or Ring D is a five-membered carbocyclic or heterocyclic ring, then R D is one of the possible ring forming substituents, and
if Z 2 is N, then R D substituents are not joined or fused into a ring.
20. The consumer product of claim 19 , wherein the consumer product is selected from the group consisting of a flat panel display, a computer monitor, a medical monitor, a television, a billboard, a light for interior or exterior illumination and/or signaling, a heads-up display, a fully or partially transparent display, a flexible display, a laser printer, a telephone, a cell phone, tablet, a phablet, a personal digital assistant (PDA), a wearable device, a laptop computer, a digital camera, a camcorder, a viewfinder, a micro-display that is less than 2 inches diagonal, a 3-D display, a virtual reality or augmented reality display, a vehicle, a video walls comprising multiple displays tiled together, a theater or stadium screen, and a sign.