Tunable detectors
Embodiments described herein relate to detectors and their method of use for sensing electromagnetic fields, electromagnetic signals, biochemical analytes, and/or other conditions in subjects. The device may include an inductively-coupled implantable coil-based transducer that converts electrical, photonic, biochemical signals, and/or other appropriate signals and/or conditions originating in tissues and/or transplanted tissue grafts into changes in a property of the transducer, such as a resonance frequency, that may be detected using an alternating magnetic field that may be provided by a magnetic resonance imaging (MRI) signal and/or other appropriate source. In some embodiments, the detector comprises a FET that changes state upon detection of a subject condition of interest. The change in the FET may change the resonance frequency of an associated LC or RLC circuit. The change in resonance frequency may change the brightness and/or intensity of the detector when detected by an MRI scanner or other appropriate scanner.
1. A detector comprising:
an antenna;
an RLC circuit including an inductor, a capacitor, and a resistor, wherein the RLC circuit is electrically coupled to the antenna;
a transistor configured to change a resonant frequency of the RLC circuit when a predetermined physical parameter is detected by the transistor; and
a substrate supporting the antenna, the RLC circuit, and the transistor, wherein the detector has a maximum dimension that is less than or equal to 1 centimeter (cm), and wherein the detector is configured to be injected and/or implanted within a subject.
2. The detector of claim 1 , wherein the transistor is connected in series with the capacitor.
3. The detector of claim 1 , wherein the transistor is connected in parallel with one of the inductor, capacitor, or resistor.
4. The detector of claim 1 , wherein the inductor, capacitor, and resistor are connected in series.
5. The detector of claim 1 , wherein the antenna is the inductor.
6. The detector of claim 1 , wherein the transistor is selected from the group consisting of a: Ion sensitive FET (ISFET), photo-sensitive FET (PHOTOFET), Chemically sensitive FET (CHEMFET), Biologically sensitive FET (BioFET), Enzyme Modified FET (EnFET), antibody sensitive and antigen functionalized FET (ImmunoFET), nanowire FET (NWFET), silicon nanowire FET (silicon NWFETs), Bipolar junction transistors (BJTs) in NPN or PNP configuration, and Magnetic Field Sensitive metal oxide silicon FET (MAGFET), or a combination of the forgoing.
7. The detector of claim 1 , wherein the predetermined physical parameter is a concentration of a biochemical analyte.
8. The detector of claim 1 , wherein the predetermined physical parameter is an electrical signal.
9. The detector of claim 1 , wherein the predetermined physical parameter is an optical signal.
10. The detector of claim 1 , wherein the antenna couples with the main coil of a magnetic resonance imaging system.
11. The detector of claim 10 , wherein detection of the predetermined physical parameter changes a gate-source voltage across the transistor and the resonant frequency of the RLC circuit.
12. The detector of claim 1 , wherein the detector is configured to be free-standing when injected and/or implanted within the subject.
13. A device, comprising:
a substrate; and
a circuit supported by the substrate and configured to electromagnetically couple to an imaging device based on resonant characteristics of the circuit, wherein the circuit is further configured to alter the resonant characteristics in response to detecting a physiological and/or biochemical parameter, wherein the device is configured to be injected and/or implanted within a subject, and wherein the device has a maximum dimension that is less than or equal to 1 centimeter (cm).
14. The device of claim 13 , wherein in response to detecting the physiological and/or biochemical parameter, the circuit is configured to alter at least one selected from the group of:
a resonant frequency of the circuit; and
an amount of resonance damping at the resonant frequency.
15. The device of claim 13 , wherein the resonant characteristics depend on a resistance, capacitance, and inductance of the circuit, and wherein the circuit includes a transistor configured to alter the resistance, capacitance, and/or inductance of the circuit in response to detecting the physiological and/or biochemical parameter.
16. The device of claim 15 , wherein the transistor is selected from the group consisting of a: Ion sensitive FET (ISFET), photo-sensitive FET (PHOTOFET), Chemically sensitive FET (CHEMFET), Biologically sensitive FET (BioFET), Enzyme Modified FET (EnFET), antibody sensitive and antigen functionalized FET (ImmunoFET), nanowire FET (NWFET), silicon nanowire FET (silicon NWFETs), Bipolar junction transistors (BJTs) in NPN or PNP configuration, and Magnetic Field Sensitive metal oxide silicon FET (MAGFET), or a combination of the forgoing.
17. The device of claim 13 , wherein the circuit is further configured to operate using power received through electromagnetically coupling to the imaging device.
18. The device of claim 13 , wherein the imaging device is a magnetic resonance imaging (MRI) system.
19. The device of claim 13 , wherein the circuit is configured to detect the physiological and/or biochemical parameter in the form of:
a voltage; and/or
an optical signal.
20. The device of claim 13 , wherein the device is configured to be injected and/or implanted within a subject for at least one day.