IP Library › Granted Patent US 11,491,202
Granted Patent B2
US 11,491,202 · App. 16/494,609 · Granted Nov 8, 2022

Herbal composition

Inventors: Patanjali Subramoni (Bangalore, IN); Sundaram Chandrasekharan (Bangalore, IN); Jayashree Madhavan (Bangalore, IN); Anilkumar K (Kerala, IN); Sarala Samuel (Kerala, IN); Bishwajit Nag (Union City, CA); Ramesh Vangal (Singapore, SG); Nitish Nag (Union City, CA); Jayarajan Kodikannath (Fremont, CA)
Assignees: KERALA AYURVEDA LIMITED (INDIA); KATRA PHYTOCHEM (INDIA) PRIVATE LIMITED
A61K36/9066A61K9/0095A61K36/185A61K36/28A61K36/48A61K36/59A61K36/61A61K36/74A61K2236/331A61K2236/333
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Quick Facts
Patent No.
US 11,491,202
App. No.
16/494,609
Granted
Nov 8, 2022
Kind
B2
Abstract

The present invention generally relates to an herbal composition effective in management of disorders related to metabolic syndrome. More particularly, the invention relates to an herbal composition effective in the management of disorders related to metabolic syndrome such as Type 2 diabetes mellitus, obesity and lipid profile management and a process for the preparation of such an herbal composition. The invention further relates to the use of the herbal composition in preparation of food supplements, pharmaceuticals and nutraceuticals for the management of disorders related to metabolic syndrome. The herbal composition effective in management of metabolic syndrome related disorders comprises of herbs selected from Curcuma longa, Emblica officinalis, Vernonia anthelmintica, Tinospora cordifolia, Trigonella foenum - graecum, Ixora coccinea and Syzygium cumini . Also provided is the use of herbal composition for the treatment of disorders related to metabolic syndrome. Also provided is a method of treating disorders related to metabolic syndrome comprising administering to a subject in need thereof a therapeutically effective amount of the herbal composition of the present invention.

Claims (30)

1. A method for treating metabolic syndrome, comprising administering an effective amount of an herbal composition to a subject in need thereof, wherein the herbal composition is obtained by:

(a) preparing a first herb blend by selecting at least four herbs selected from the group consisting of Curcuma longa, Emblica officinalis, Vernonia anthelmintica, Tinospora cordifoha, Trigonella foenum - graecum, Ixora coccinea, Syzygium cumini , wherein the first herbs selected in the first herb blend are present in equal amounts by weight;

(b) extracting the first herb blend by a hydro-alcohol extraction process to obtain a first herb blend extract solution;

(c) preparing a second herb blend comprising herbs Curcuma longa and Emblica officinalis in a ratio of 1:1 to 1:3;

(d) extracting the second herb blend by the hydro-alcohol extraction process to obtain a second herb blend extract solution; and

(e) mixing the first herb blend extract solution and the second herb blend extract solution in a ratio of 1:1 to obtain an extract mix;

distilling and concentrating the extract mix to obtain the herbal composition; and

formulating the herbal composition in a suitable dosage form including powder or paste, wherein the hydro-alcohol extraction process comprises:

pulverizing and sifting the herbs;

obtaining an extract using a solvent that includes a mixture of alcohol and water in a ratio within a range of 80:20 to 20:80, at reflux or under circulation at 75° C. for 2 hours; and

filtering the extract to obtain the herb blend extract solution.

2. The method of claim 1 , wherein:

the first herb blend comprises herbs Curcuma longa, Emblica officinalis, Vernonia anthelmintica, Tinospora cordifolia, Trigonella foenum - graecum, Ixora coccinea and Syzygium curnini wherein the said herbs are present in equal amounts.

3. The method of claim 1 , wherein:

the first herb blend optionally comprises herbs Curcuma longa, Emblica officinalis, Vernonia anthelmintica, Tinospora cordifolia, Trigonella foenum - graecum and Ixora coccinea wherein the said herbs are present in equal amounts.

4. The method of claim 1 , wherein:

the first herb blend optionally comprises herbs Curcuma longa, Emblica officinalis, Vernonia anthelmintica, Tinospora cordifolia and Trigonella foenum - graecum wherein the said herbs are present in equal amounts.

5. The method of claim 1 , wherein:

the first herb blend optionally, comprises herbs from Curcuma longa, Emblica officinalis, Vernonia anthelmintica and Tinospora cordifolia wherein the said herbs are present in equal amounts.

6. The method of claim 1 , wherein the herbal composition further comprises pharmaceutically acceptable excipients, wherein the excipients are selected from a group consisting of additives, gums, sweeteners, coatings, binders, disintegrants, lubricants, disintegration agents, suspending agents, granulating agents, solvents, colorants, glidants, anti-adherents, anti-static agents, surfactants, plasticizers, emulsifying agents, flavoring agents, viscosity enhancers and antioxidants to provide a pharmaceutical composition.

7. The method of claim 1 , wherein the herbal composition is formulated to prepare suitable dosage forms selected from a group consisting of granule, capsule, tablet, liquid, lozenges, beverages, emulsion, suspension, syrups, elixirs, oral drops, jellies, phytoceuticals, food supplements and nutraceuticals.

8. The method of claim 7 , wherein the herbal composition is used in wheat flour, soups, cookies, biscuits, dairy foods and other processed foods.

9. The method of claim 1 , wherein the herbal composition is effective in management of disorders related to metabolic syndrome such as Type 2 diabetes by controlling blood glucose, in obesity, in lipid profile management of an individual in arresting body weight gain and in preventing body weight gain on a continued therapy basis.

10. The method of claim 1 , wherein the first herb blend optionally, comprises herbs Tinospora cordifolia, Trigonella foenum - graecum, Ixora coccinea, Syzygium cumini wherein the said herbs are present in equal amounts; and the second herb blend comprises herbs Curcuma longa and Emblica officinalis in a ratio of 1:1 to 1:3.

11. The method of claim 10 , wherein an effective amount of the herbal composition is administered to a patient to reduce glucose in plasma, reduce triglyceride levels in plasma, and to reduce serum cholesterol levels.

12. The method of claim 1 , wherein the specific plant parts of raw herbs in the first herb blend and the second herb blend comprise dried rhizome of Curcuma longa , stem of Tinospora cordifolia , dried pericarp of Emblica officinalis , root of Ixora coccinea , bark of Syzygium cumini , seeds of Trigonella foenum - graecum and fruits of Vernonia anthelmintica.

13. The method of claim 1 , wherein the alcohol in the solvent is selected from methyl alcohol, ethyl alcohol and iso-propyl alcohol, preferably ethyl alcohol.

14. The method of claim 13 , wherein the ratio of alcohol and water in the solvent is 50:50 or 70:30.

15. The method of claim 1 , wherein an effective amount of the herbal composition is administered to a patient to reduce glucose in plasma, reduce triglyceride levels in plasma, and to reduce serum cholesterol levels.

16. The method of claim 1 , wherein the herbal composition is used in preparation of food products and beverages, including tea, infusions, drinks, and water.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 7, 2022
From: SUBRAMONI, PATANJALI; CHANDRASEKHARAN, SUNDARAM; MADHAVAN, JAYASHREE; K, ANILKUMAR; SAMUEL, SARALA; NAG, BISHWAJIT; VANGAL, RAMESH; NAG, NITISH; KODIKANNATH, JAYARAJAN
To: KERALA AYURVEDA LIMITED (INDIA); KATRA PHYTOCHEM (INDIA) PRIVATE LIMITED
Reel/Frame 061011/0624 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 19, 2022
From: SUBRAMONI, PATANJALI; CHANDRASEKHARAN, SUNDARAM; MADHAVAN, JAYASHREE; K, ANILKUMAR; SAMUEL, SARALA; NAG, BISHWAJIT; VANGAL, RAMESH; NAG, NITISH; KODIKANNATH, JAYARAJAN
To: KERALA AYURVEDA LIMITED (INDIA); KATRA PHYTOCHEM (INDIA) PRIVATE LIMITED
Reel/Frame 061281/0503 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 17, 2022
From: SUBRAMONI, PATANJALI; CHANDRASEKHARAN, SUNDARAM; MADHAVAN, JAYASHREE; K, ANILKUMAR; SAMUEL, SARALA; NAG, BISHWAJIT; VANGAL, RAMESH; NAG, NITISH; KODIKANNATH, JAYARAJAN
To: KERLA AYURVEDA LIMITED (INDIA); KATRA PHYTOCHEM (INDIA) PRIVATE LIMITED
Reel/Frame 060837/0469 →
Continuity (2)
Provisional Application 62473126 · Mar 17, 2017
Related Publication 20200085904A1 · Mar 19, 2020