Methods and apparatus for oxygenation and/or CO2 removal
Described is an apparatus for oxygenation and/or CO2 clearance of a patient, comprising: a flow source or a connection for a flow source for providing a gas flow, a gas flow modulator, a controller to control the gas flow, wherein the controller is operable to: receive input relating to heart activity and/or trachea gas flow of the patient, and control the gas flow modulator to provide a varying gas flow with one or more oscillating components with a frequency or frequencies based on the heart activity and/or trachea flow of the patient.
1. An apparatus for oxygenation or CO 2 clearance of a patient, or a combination thereof, during a medical procedure wherein during the medical procedure the patient is apnoeic for at least a portion of the medical procedure or the patient is under anesthesia causing diminished or risk of diminished respiratory function, comprising:
a flow source or a connection for a flow source configured to provide a gas flow;
a gas flow modulator; and
a controller configured to control a flow rate of the gas flow during a preoxygenation stage of the medical procedure or when the patient is under anesthesia, the controller configured to control the flow rate by controlling the gas flow modulator to oscillate the flow rate based on an oscillating flow rate component and a base flow rate component to provide a varying gas flow with one or more frequencies,
wherein the controller is configured to control the gas flow between a set flow rate before the patient is apneic, or has a diminished, or is at risk of diminished, respiratory function and a base flow rate of the base flow rate component when the patient is apneic, or has a diminished, or is at risk of diminished, respiratory function; and
wherein the apparatus is configured to provide the gas flow to a non-sealing patient interface.
2. The apparatus according to claim 1 wherein the oscillating flow rate component has an oscillating flow rate and the controller is configured to control the gas flow modulator to provide the oscillating flow rate within a range of about 0 litres/min to about 375 litres/min.
3. The apparatus according to claim 2 wherein the base flow rate of the base flow rate component is within a range of about 0 litres/min to about 375 litres/min.
4. The apparatus according to claim 2 wherein the base flow rate of the base flow rate component is in a range of about 0.2 litres/min per patient kilogram to about 2.5 litres/min per patient kilogram.
5. The apparatus according to claim 2 wherein the flow source or the connection for the flow source is configured to provide the gas flow for use on persons greater than about 30 kg.
6. The apparatus according to claim 2 wherein the oscillating flow rate comprises one or more frequencies in a range of about 0.1 Hz to about 3 Hz.
7. The apparatus according to claim 2 wherein the oscillating flow rate is in a range of 0.05 litres/min per patient kilogram to 2 litres/min per patient kilogram.
8. The apparatus according to claim 2 wherein the flow source or the connection for the flow source is configured to provide the gas flow for use on persons within a range of about 0.3 to 30 kg.
9. The apparatus according to claim 2 wherein a base flow rate of the base flow rate component is about 8 litres/min for a person under about 2 kilograms.
10. The apparatus according to claim 1 wherein the gas flow modulator comprises an underwater pressure release valve, an oscillatable diaphragm, an in-line linear actuator, a flow chopper, an aerodynamic flutter valve, a mechanical flutter valve, or a proportional valve.
11. The apparatus according to claim 1 wherein the gas flow modulator is in or after the flow source.
12. The apparatus according to claim 1 wherein the gas flow has an oxygen fraction of 100%, or in a range of 30-40% or in a range of 40-50% or in a range of 60-70% or in a range of 80-90% or in a range of 90-100%.
13. The apparatus according to claim 1 wherein the gas flow is air.
14. The apparatus according to claim 1 wherein the non-sealing patient interface comprises or is configured for use with a high flow nasal cannula.
15. The apparatus according claim 1 further comprising a humidifier to humidify the gas flow before or after it is oscillated.
16. The apparatus according to claim 1 wherein the controller is configured to determine when the apnoea in the patient has commenced or to detect an anaesthesia stage or change in anaesthesia stage in the patient.
17. The apparatus according to claim 10 wherein the gas flow modulator is or comprises the proportional valve, and the proportional valve has a variable size orifice that is variable based on an electrical signal.
18. The apparatus according to claim 3 wherein the base flow rate is within a range of about 30 litres/min to about 90 litres/min.
19. The apparatus according to claim 1 wherein the one or more frequencies comprises at least two frequencies.
20. The apparatus according to claim 19 wherein the at least two frequencies are in a range of about 0.1 Hz to about 3 Hz.
21. The apparatus according to claim 1 wherein the base flow rate is higher than the set flow rate.
22. A method for oxygenation or CO 2 clearance of a patient, or a combination thereof, comprising:
controlling, via a controller, a gas flow to the patient via a non-sealing nasal interface during a preoxygenation stage of a medical procedure or when the patient is under anesthesia;
determining or detecting a stage of the medical procedure; and
based on the stage determined or detected, varying the gas flow delivered to the patient by oscillating a flow rate of the gas flow based on an oscillating flow rate component and a base flow rate component when the patient is apneic or has a diminished risk or is at risk of diminished respiratory function;
wherein the varying gas flow comprises a set flow rate before the patient is apneic, or has a diminished, or is a risk of diminished, respiratory function and a base flow rate of the base flow rate component when the patient is apneic, or has a diminished, or is at risk of diminished, respiratory function.
23. The method according to claim 22 wherein a base flow rate of the base flow rate component is in a range of about 0.2 litres/min per patient kilogram to about 2.5 litres/min per patient kilogram.
24. The method according to claim 22 wherein the non-sealing nasal interface comprises or is configured for use with a high flow nasal cannula.
25. The method according to claim 22 wherein the determining or detecting the stage of the medical procedure further comprises determining when the apnoea in the patient has commenced or detecting an anaesthesia stage or change in anaesthesia stage in the patient.
26. The method according to claim 22 wherein the varying gas flow comprises at least two frequencies.
27. The method according to claim 26 wherein the at least two frequencies are in a range of about 0.1 Hz to about 3 Hz.
28. The method according to claim 22 wherein the base flow rate is higher than the set flow rate.