Neurosteroids and enantiomers thereof for the prevention and treatment of neurodegenerative conditions
The present disclosure is directed to a composition for prevention or treatment of neurodegenerative conditions. The composition comprises a neurosteroid, a synthetic enantiomer of a neurosteroid, or a combination thereof.
1. A method of preventing or treating a neurodegenerative condition comprising inducing autophagy by administering an effective amount of a composition comprising a synthetic enantiomer of a neurosteroid, wherein the neurodegenerative condition is glaucoma and the synthetic entantiomer of the neurosteroid is ent-allopregnanolone.
2. The method of claim 1 , wherein the composition further comprises a saline solution.
3. The method of claim 1 , wherein administering an effective amount of the composition comprises administering the composition by intravitreal injection.
4. The method of claim 1 , wherein administering an effective amount of the composition comprises administering the composition by intracameral injection.
5. The method of claim 1 , wherein the synthetic enantiomer of the neurosteroid has a concentration of from about 10 nM to about 100 μM.
6. A method of attenuating pressure- induced retinal injury, the method comprising administering an effective amount of a composition comprising a synthetic enantiomer of a neurosteroid, wherein the injury is glaucoma and the synthetic entantiomer of the neurosteroid is ent-allopregnanolone.
7. The method of claim 6 , wherein the composition further comprises a saline solution.
8. The method of claim 6 , wherein administering an effective amount of the composition comprises administering the composition by intravitreal injection.
9. The method of claim 6 , wherein administering an effective amount of the composition comprises administering the composition by intracameral injection.
10. The method of claim 6 , wherein the synthetic enantiomer of the neurosteroid has a concentration of from about 10 nM to about 100 μM.