Systems and methods for selecting, positioning, and controlling cardiac resynchronization therapy (CRT) electrodes

1. A cardiac resynchronization therapy (CRT) system comprising:

electrodes configured to be positioned on or in proximity to a subject's heart for receiving electrical signals carrying EGM data; and

a CRT device operatively connected to the electrodes, and the CRT device being configured to:

receive the electrical signals from the electrodes when the electrodes are positioned in a first arrangement with respect to the subject's heart, wherein the electrical signals are received during CRT pacing of the subject's heart by the CRT device and during native conduction of the electrodes;

calculate EGM area (EGMA) during CRT pacing and native conduction based on the received electrical signals;

calculate the change in EGMA (ΔEGMA) between CRT pacing and native conduction;

determine a second arrangement of the electrodes with respect to the subject's heart based on the EGMA and among a plurality of different arrangements such that the ΔEGMA is optimized to improve patient outcomes; and

present the second arrangement of the electrodes.

2. The CRT system of claim 1 , wherein the CRT device is one of an implantable CRT device, a pacemaker, and a defibrillator.

3. The CRT system of claim 1 , wherein the electrodes are configured to be positioned on one or more of a surface of a body of a subject, within a thorax of the body, on a heart of the body, on a surrounding venous structure of the body, and/or on a surrounding subcutaneous structure of the body.

4. The CRT system of claim 1 , wherein the electrical signals are received during CRT pacing of the subject's heart by the CRT device.

5. A cardiac resynchronization therapy (CRT) system comprising:

electrodes configured to be positioned on or in proximity to a subject's heart for receiving electrical signals carrying EGM data wherein the carried EGM data is associated with ventricular depolarization from the electrodes; and

a CRT device operatively connected to the electrodes, and the CRT device being configured to:

receive the electrical signals from the electrodes when the electrodes are positioned in a first arrangement with respect to the subject's heart;

calculate EGM area (EGMA) based on the received electrical signals;

determine a baseline electrical dyssynchrony based on the carried EGM data;

determine a risk of the subject having a cardiac episode based on the baseline electrical dyssynchrony;

determine a second arrangement of the electrodes with respect to the subject's heart based on the EGMA and based on an algorithm to reduce or eliminate the risk and to optimize EGMA; and

present the second arrangement of the electrodes.

6. A cardiac resynchronization therapy (CRT) system comprising:

electrodes configured to be positioned on or in proximity to a subject's heart for receiving electrical signals carrying EGM data; and

a CRT device operatively connected to the electrodes, and the CRT device being configured to:

receive the electrical signals from the electrodes when the electrodes are positioned in a first arrangement with respect to the subject's heart, wherein the electrical signals are received during CRT pacing of the subject's heart by the CRT device and during non His-bundle pacing of the electrodes, and wherein electrical signal are received during CRT pacing of the subject's heart by the CRT device and during His-bundle pacing,

calculate the EGM area (EGMA) during CRT pacing and native conduction based on the received electrical signals;

calculate EGMA during the His-bundle or conduction system pacing;

calculate the change in EGMA (ΔEGMA) between native conduction; and

determine, based on the ΔEGMA, a second arrangement of the electrodes with respect to the subject's heart based on the EGMA such that the ΔEGMA is optimized; and

present the second arrangement of the electrodes.

7. A method comprising:

positioning electrodes of a cardiac resynchronization therapy (CRT) device on or in proximity to a subject's heart for receiving electrical signals carrying EGM data;

receiving the electrical signals from the electrodes when the electrodes are positioned in a first arrangement with respect to the subject's heart;

receiving the electrical signals during CRT pacing of the subject's heart by the CRT device and during native conduction of the electrodes;

calculating, during CRT pacing and native conduction, EGM area (EGMA) based on the received electrical signals;

calculating the change in EGMA (ΔEGMA) between CRT pacing and native conduction;

determining a second arrangement of the electrodes with respect to the subject's heart based on the EGMA and among a plurality of different arrangements such that the ΔEGMA is optimized; and

presenting the second arrangement of the electrodes.

8. The method of claim 7 , further comprising positioning the electrodes on one or more of a surface of a body of a subject, within a thorax of the body, on a heart of the body, on a surrounding venous structure of the body, and on a surrounding subcutaneous structure of the body.

9. The method of claim 7 , further comprising receiving the electrical signals during CRT pacing of the subject's heart by the CRT device.

10. A method comprising:

positioning electrodes of a cardiac resynchronization therapy (CRT) device on or in subject's heart for receiving electrical signals carrying EGM data, wherein the carried EGM data is associated with ventricular depolarization from the electrodes;

receiving the electrical signals from the electrodes when the electrodes are positioned in a first arrangement with respect to the subject's heart;

calculating EGM area (EGMA) based on the received electrical signals;

determining a baseline electrical dyssynchrony based on the carried EGM data;

determining a risk of the subject having a cardiac episode based on the baseline electrical dyssynchrony; and

determining a second arrangement of the electrodes with respect to the subject's heart and based on the EGMA based on an algorithm to reduce or eliminate the risk and to optimize EGMA; and

presenting the second arrangement of the electrodes.

11. The method of claim 7 , wherein the CRT device is one of an implantable CRT device, a pacemaker, and a defibrillator.