Therapeutic drug for lipid-peroxidation-induced diseases and screening method for therapeutic drugs for lipid-peroxidation-induced diseases
The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-related macular degeneration) that are induced by lipid peroxidation reactions.
1. An assay kit for detecting lipid peroxidation inhibitory activity of a test compound, comprising:
a compound represented by formula (I):
a liposome, and
at least one compound selected from the group consisting of 2,2′-azobis(2-aminopropane) dihydrochloride and a divalent iron ion source material
in a buffer.
2. The assay kit according to claim 1 , wherein the divalent iron ion source material is iron(II) sulfate.
3. The assay kit according to claim 1 , comprising a package insert showing an activity value of a compound having lipid peroxidation inhibitory activity.
4. An assay kit comprising any two or more of the assay kits according to claim 1 .