Pharmaceutical compositions for preventing or treating pulmonary metastasis of cancer including CHI3L1 inhibitor as active ingredient
View Patent ↗The present invention relates to pharmaceutical compositions for preventing or treating pulmonary metastasis of cancer. More specifically, the present invention relates to compositions that enhance anti-cancer immunity of the lung rather than induce death of advanced cancer, thus being effective in inhibiting, preventing or treating pulmonary metastasis of cancer.
1. A pharmaceutical composition comprising, as an active ingredient, a complex of a cell-penetrating peptide having the sequence set forth in SEQ ID NO: 2 and a Chi3l1 siRNA having the sequence set forth in SEQ ID NO: 1.
2. The pharmaceutical composition according to claim 1 , wherein the pharmaceutical composition has the ability to penetrate the nasal mucosa, the bronchial mucosa or pulmonary epithelial cells.
3. A method for preventing or treating pulmonary metastasis of cancer in a subject in need thereof, comprising administering the pharmaceutical composition according to claim 1 to the subject via an intranasal route.
4. The method for preventing or treating pulmonary metastasis of cancer according to claim 3 , wherein the administering is an inhalation of a spray or powder.