IP Library Granted Patent US 11,527,392
Granted Patent B2
US 11,527,392 · App. 17/057,964 · Granted Dec 13, 2022

Mass spectrometry device and mass spectrometry method

Inventors: Minoru Fujimoto (Kyoto, JP); Hideki Yamamoto (Kyoto, JP)
Assignee: SHIMADZU CORPORATION
H01J49/0031G01N27/62H01J49/02H01J49/40
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Quick Facts
Patent No.
US 11,527,392
App. No.
17/057,964
Granted
Dec 13, 2022
Kind
B2
Abstract

A precursor ion selection processing unit ( 22 ) sequentially selects precursor ions having different mass-to-charge ratios, and causes an MS/MS spectrum data acquisition processing unit ( 23 ) to acquire MS/MS spectrum data corresponding to each precursor ion. The precursor ion selection processing unit ( 22 ) sequentially selects the precursor ion having a mass-to-charge ratio which is not included in a predetermined range with respect to a mass-to-charge ratio of the precursor ion for which the MS/MS spectrum data has already been acquired.

Claims (18)

1. A mass spectrometry device comprising:

an MS spectrum data acquisition processing unit that acquires MS spectrum data by ionizing a sample and performing mass spectrometry;

a precursor ion selection processing unit that selects a precursor ion on the basis of the MS spectrum data;

an MS/MS spectrum data acquisition processing unit that acquires MS/MS spectrum data by cleaving the selected precursor ion and performing mass spectrometry; and

a display processing unit that displays the MS/MS spectrum data acquired by the MS/MS spectrum data acquisition processing unit,

wherein the precursor ion selection processing unit sequentially selects precursor ions having different mass-to-charge ratios, causes the MS/MS spectrum data acquisition processing unit to acquire MS/MS spectrum data corresponding to each of the precursor ions, and sequentially selects the precursor ion having a mass-to-charge ratio which is not included in a predetermined range with respect to a mass-to-charge ratio of the precursor ion for which the MS/MS spectrum data has already been acquired on the basis of the same MS spectrum data,

wherein the predetermined range is a range including the mass-to-charge ratio or a range of the mass-to-charge ratio of the precursor ion for which the MS/MS spectrum data has already been acquired,

wherein the display processing unit displays, as the MS/MS spectrum data corresponding to an ion which is not selected as the precursor ion by the precursor ion selection processing unit, the MS/MS spectrum data corresponding to the precursor ion including the mass-to-charge ratio of the ion within the predetermined range, and

the display processing unit displays a retention time of the ion which is not selected as the precursor ion.

2. A mass spectrometry method comprising:

an MS spectrum data acquisition step of acquiring MS spectrum data by ionizing a sample and performing mass spectrometry;

a precursor ion selection step of selecting a precursor ion on the basis of the MS spectrum data; and

an MS/MS spectrum data acquisition step of acquiring MS/MS spectrum data by cleaving the selected precursor ion and performing mass spectrometry; and

a display step of displaying the MS/MS spectrum data acquired by the MS/MS spectrum data acquisition step,

wherein the precursor ion selection step sequentially selects precursor ions having different mass-to-charge ratios, causes the MS/MS spectrum data acquisition step to acquire MS/MS spectrum data corresponding to each of the precursor ions, and sequentially selects the precursor ion having a mass-to-charge ratio which is not included in a predetermined range with respect to a mass-to-charge ratio of the precursor ion for which the MS/MS spectrum data has already been acquired on the basis of the same MS spectrum data,

wherein the predetermined range is a range including the mass-to-charge ratio or a range of the mass-to-charge ratio of the precursor ion for which the MS/MS spectrum data has already been acquired,

wherein the display step displays, as the MS/MS spectrum data corresponding to an ion which is not selected as the precursor ion by the precursor ion selection step, the MS/MS spectrum data corresponding to the precursor ion including the mass-to-charge ratio of the ion within the predetermined range, and

in the display step, a retention time of the ion which is not selected as the precursor ion is displayed.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 23, 2020
From: FUJIMOTO, MINORU; YAMAMOTO, HIDEKI
To: SHIMADZU CORPORATION
Reel/Frame 055005/0825 →
Continuity (1)
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