Medical hydrogel
The present application relates to a medical hydrogel comprising nanofibrillar cellulose, wherein the hydrogel has a viscosity in the range of 2500-9000 Pa·s and a water retention value in the range of 30-100 g/g. The present application also relates to a method for preparing the medical hydrogel The present application relates to the medical hydrogel for use for treating wounds.
1. A medical hydrogel comprising nanofibrillar cellulose, wherein the hydrogel has a solids content in the range of 4-8% (w/w) and a viscosity in the range of 2500-9000 Pa·s measured at a solids content of 4-8% (w/w), at 37° C. and a shear rate of 0.1 s −1 , and a water retention value in the range of 30-100 g/g, wherein the nanofibrillar cellulose is anionically modified via 2,2,6,6-tetramethylpiperidinyl-1-oxy (TEMPO) oxidation.
2. The medical hydrogel of claim 1 , wherein the hydrogel has a solids content in the range of 4.5-8% (w/w).
3. The medical hydrogel of claim 1 , wherein the hydrogel has a compression work in the range of 15-60 J/m 2 .
4. The medical hydrogel of claim 1 containing one or more therapeutic agent(s).
5. A method for preparing a medical hydrogel, the method comprising
providing wood pulp,
anionically modifying the pulp, via 2,2,6,6-tetramethylpiperidinyl-1-oxy (TEMPO) oxidation,
disintegrating the pulp until nanofibrillar cellulose is obtained,
forming the nanofibrillar cellulose into a hydrogel, wherein the hydrogel has a solids content in the range of 4-8% (w/w) and a viscosity in the range of 2500-9000 Pas measured at a solids content of 4-8% (w/w), at 37° C. and a shear rate of 0.1 s −1 , and a water retention value in the range of 30-100 g/g.
6. The method of claim 5 , wherein the hydrogel has a solids content in the range of 4.5-8% (w/w).
7. The method of claim 5 , wherein the hydrogel has a compression work in the range of 15-60 J/m 2 .
8. The method of claim 5 , wherein the obtained nanofibrillar cellulose, when dispersed in water, provides a Brookfield viscosity of 500-10000 mPa·s, measured at a consistency of 0.8% (w/w) and at 10 rpm.
9. A kit containing the medical hydrogel of claim 1 packed in one or more sealed package(s), or in one or more application device(s) selected from a syringe, an applicator, a pump, and a tube.
10. A method for treating skin wounds or other damages or injuries, the method comprising applying the medical hydrogel of claim 1 onto the wound, damage, or injury.
11. The method of claim 10 , wherein the skin wound is an open wound selected from abrasions, avulsions, incisions, lacerations, puncture wounds or penetration wounds.
12. The method of claim 10 , wherein the skin wound is covered with a skin graft, and the method comprises applying the medical hydrogel onto the skin graft.
13. The medical hydrogel of claim 1 , wherein the hydrogel has a solids content in the range of 5-7% (w/w), a viscosity in the range of 3000-8000 Pa-s, measured at a solids content of 5-7% (w/w), at 37° C. and a shear rate of 0.1 s −1 , and a water retention value in the range of 40-50 g/g.
14. The medical hydrogel of claim 1 , wherein the hydrogel has a compression work in the range of 25-40 J/m 2 .
15. The method of claim 5 , wherein the hydrogel has a solids content in the range of 5-7% (w/w), a viscosity in the range of 3000-8000 Pa-s, measured at a solids content of 5-7% (w/w), at 37° C. and a shear rate of 0.1 s −1 , and a water retention value in the range of 40-50 g/g.
16. The method of claim 5 , wherein the hydrogel has a compression work in the range of 25-40 J/m 2 .