Compositions and methods for antigen targeting to CD180

1. A composition, comprising:

(a) an antibody or antibody fragment that binds CD180; and

(b) a heterologous antigen attached to the antibody or antibody fragment that binds CD180.

2. The composition of claim 1 , wherein the heterologous antigen is a polysaccharide, carbohydrate, or a glycolipid antigen.

3. The composition of claim 1 , wherein the heterologous antigen is an allergen.

4. The composition of claim 1 , wherein the heterologous antigen is a pathogen-specific antigen.

5. The composition of claim 1 , wherein the antibody or antibody fragment that binds CD180 is a CD180 monoclonal antibody or antibody fragment.

6. The composition of claim 5 , wherein the CD180 monoclonal antibody or antibody fragment comprises a human or animal CD180 binding domain linked to an immunoglobulin constant region (Fc) domain that has impaired binding to human or animal Fc receptor FcγRIIb and/or to human or animal complement proteins.

7. The composition of claim 1 , wherein the composition further comprises an adjuvant.

8. The composition of claim 7 , wherein the adjuvant is a toll-like receptor agonist.

9. A pharmaceutical composition, comprising:

(a) the composition of claim 1 ; and

(b) a pharmaceutically acceptable carrier.

10. The composition of claim 2 , wherein the antibody or antibody fragment that binds CD180 is a CD180 monoclonal antibody or antibody fragment.

11. The composition of claim 3 , wherein the antibody or antibody fragment that binds CD180 is a CD180 monoclonal antibody or antibody fragment.

12. The composition of claim 4 , wherein the antibody or antibody fragment that binds CD180 is a CD180 monoclonal antibody or antibody fragment.

13. The composition of claim 10 , wherein the composition further comprises an adjuvant.

14. The composition of claim 11 , wherein the composition further comprises an adjuvant.

15. The composition of claim 12 , wherein the composition further comprises an adjuvant.