18F-labeled PSMA-targeted PET imaging agents
View Patent ↗Compounds of Marlush formula (I) described in the claims are useful in diagnostic methods for detecting and/or identifying cells presenting PSMA. Disclosed are also methods for preparing the compounds. Representative compounds according to the application are:
1. A compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein
each R is independently hydrogen or a protecting group.
2. The compound of claim 1 , wherein the compound is of the formula:
or a pharmaceutically acceptable salt thereof.
3. A composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier, excipient, and/or diluent.
4. A compound which is:
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 , wherein R is benzyl or tert-butyl.
6. A salt of a compound of claim 4 , wherein the salt is:
7. A salt of a compound of claim 4 , wherein the salt is:
8. A pharmaceutical composition comprising a salt of a compound of claim 4 , together with a pharmaceutically acceptable carrier, excipient, and/or diluent, wherein the salt is:
9. A pharmaceutical composition comprising a salt of a compound of claim 4 , together with a pharmaceutically acceptable carrier, excipient, and/or diluent wherein the salt is:
10. A pharmaceutical composition according to claim 8 , wherein the pharmaceutically acceptable carrier, excipient, and/or diluent comprises sterile saline.
11. A pharmaceutical composition according to claim 9 , wherein the pharmaceutically acceptable carrier, excipient, and/or diluent comprises sterile saline.
12. A compound which is
or a pharmaceutically acceptable salt thereof.
13. A salt of a compound of claim 12 , wherein the salt is:
14. A salt of a compound of claim 12 wherein the salt is:
15. A pharmaceutical composition comprising a salt of a compound of claim 12 , together with a pharmaceutically acceptable carrier, excipient, and/or diluent, wherein the salt is:
16. A pharmaceutical composition comprising a salt of a compound of claim 12 , together with a pharmaceutically acceptable carrier, excipient, and/or diluent wherein the salt is:
17. A pharmaceutical composition according to claim 15 , wherein the pharmaceutically acceptable carrier, excipient, and/or diluent comprises sterile saline.
18. A pharmaceutical composition according to claim 16 , wherein the pharmaceutically acceptable carrier, excipient, and/or diluent comprises sterile saline.