Compositions and methods for the treatment of neurological diseases

1. A compound of Formula I

wherein

RH is caprylic acid, adipic acid, capric acid, caproic acid, cinnamic acid, cyclamic acid, dodecylsulfuric acid, galactaric acid, gentisic acid, glucuronic acid, glutaric acid, glycerophosphoric acid, malonic acid, nicotinic acid, oleic acid, oxalic acid, palmitic acid, sebacic acid, omega 3 fatty acids, omega 6 fatty acids, n-acetyl cysteine, caprilic acid, alpha lipoic acid, R-lipoic acid, myristic acid, myristoleic acid, palmitoleic acid, phospholipids, phosphatidylcholine, elaidic acid, linoleic acid, linolenic acid, menthol, retinoic acid, vitamin A, retinol, linolelaidic acid, arachidonic acid, retinal, isotretinoin, curcumin, tretinoin, α-carotene, β-carotene, d2 ergosterol, ergocalciferol, 7-dehydrocholesterol, cholecalciferol, 25-hydroxycholecalciferol, calcitriol (1,25-dihydroxycholecalciferol), calcitroic acid, d4 dihydroergocalciferol, alfacalcidol, dihydrotachysterol, calcipotriol, tacalcitol, paricalcitol, tocopherol, naphthoquinone, phylloquinone, menaquinones, menadione, menadiol, thiamine, acefurtiamine, allithiamine, benfotiamine, fursultiamine, octotiamine, prosultiamine, sulbutiamine, riboflavin, niacin, nicotinamide, dexpanthenol, pantethine, pyridoxine, pyridoxal phosphate, pyridoxamine, pyritinol, biotin, folic acid, dihydrofolic acid, folinic acid, levomefolic acid, adenosylcobalamin, cyanocobalamin, hydroxocobalamin, methylcobalamin, choline, dehydroascorbic acid, 1-docosanol or

wherein, each of R 1 , R 2 and R 3 is independently

or a pharmaceutically acceptable hydrate, solvate, enantiomer, and stereoisomer thereof.

2. A compound of Formula II

wherein

RH is caprylic acid, adipic acid, capric acid, caproic acid, cinnamic acid, cyclamic acid, dodecylsulfuric acid, galactaric acid, gentisic acid, glucuronic acid, glutaric acid, glycerophosphoric acid, malonic acid, nicotinic acid, oleic acid, oxalic acid, palmitic acid, sebacic acid, undecylenic acid, omega 3 fatty acids, omega 6 fatty acids, n-acetyl cysteine caprilic acid, alpha lipoic acid, R-lipoic acid, myristic acid, myristoleic acid, palmitoleic acid, phospholipids, phosphatidylcholine, elaidic acid, linoleic acid, linolenic acid, menthol, retinoic acid, vitamin A, retinol, linolelaidic acid, arachidonic acid, retinal, isotretinoin, curcumin, tretinoin, α-carotene, β-carotene, d2 ergosterol, ergocalciferol, 7-dehydrocholesterol, cholecalciferol, 25-hydroxycholecalciferol, calcitriol (1,25-dihydroxycholecalciferol), calcitroic acid, d4 dihydroergocalciferol, alfacalcidol, dihydrotachysterol, calcipotriol, tacalcitol, paricalcitol, tocopherol, naphthoquinone, phylloquinone, menaquinones, menadione, menadiol, thiamine, acefurtiamine, allithiamine, benfotiamine, fursultiamine, octotiamine, prosultiamine, sulbutiamine, riboflavin, niacin, nicotinamide, dexpanthenol, pantethine, pyridoxine, pyridoxal phosphate, pyridoxamine, pyritinol, biotin, folic acid, dihydrofolic acid, folinic acid, levomefolic acid, adenosylcobalamin, cyanocobalamin, hydroxocobalamin, methylcobalamin, choline, dehydroascorbic acid, 1-docosanol or

wherein, each of R 1 , R 2 and R 3 is independently

or a pharmaceutically acceptable hydrate, solvate, enantiomer, and stereoisomer thereof.

3. A compound of claim 1 , wherein the ketamine moiety in the compound of formula I is selected from an R enantiomer, an S enantiomer, or a racemic mixture comprising equal portions of R and S enantiomers of the ketamine.

4. A compound of claim 2 , wherein the ketamine moiety in the compound of formula II is an S-enantiomer of the ketamine.

5. A compound of claim 1 , wherein the compound is selected from a group consisting of

and pharmaceutically acceptable hydrates, solvates, enantiomers, and stereoisomers thereof.

6. A compound of claim 2 , wherein the compound is selected from a group consisting of

and pharmaceutically acceptable hydrates, solvate, enantiomer, and stereoisomer thereof.

7. A pharmaceutical composition comprising a compound of claim 1 as an active ingredient in a therapeutically effective amount; and a pharmaceutically acceptable excipient and/or pharmaceutically acceptable carrier.

8. The pharmaceutical composition of claim 7 , wherein the pharmaceutically acceptable excipient is selected from the group comprising of a stabilizer, an inert carrier, a vehicle, a diluent, a surfactant, a filler, a humectant, an adsorbent, an antiadherent, a binder, a lubricant, a glidant, a super disintegrant, a disintegrant, a preservative, an antioxidant, a solution retarding agent, an absorption accelerator, a wetting agent, an absorbent, a coloring agent, a flavoring agent, a sorbent, a coating agent, a sweetener, a buffering agent, a propellant, and mixtures thereof.

9. The pharmaceutical composition of claim 7 , wherein the pharmaceutical composition is formulated as an oral dosage form, systemic dosage form, topical dosage form, spray, parenteral dosage form, subdermal dosage form, or transdermal dosage form.

10. The pharmaceutical composition of claim 7 , wherein the pharmaceutical composition is formulated in a unit dosage form selected from the group consisting of tablet, sublingual tablet, mucoadhesive tablet, multilayer tablet, capsule, capsules containing tablet, controlled-release form, sustained-release form, suppository, tampons, pessaries, pill, lozenge, powder, beads, granule, nanoparticles, beads or granules in solid or liquid forms, oral spray, nasal spray, mucoadhesive spray, intra nasal spray, foam, nasal inhaler, liquid solution, syrups, elixirs, emulsions, microemulsions, subdermal autoinjector, intramuscular autoinjector, injection, stereotactic injection, liquid suspension, intravenous suspension, sterile parenteral solution, sterile parenteral suspension, sterile non-parenteral solution, sterile non-parenteral suspension, topical ointment, topical paste, topical cream, topical lotion, topical gel, and transdermal patch.

11. A method of the treatment or amelioration of neurological diseases or an associated complication, wherein the associated complication is selected from the group consisting of depression, treatment resistant depression, chronic pain and combinations thereof, and comprising administering to a patient suffering from neurological diseases or associated complications the compound of claim 1 as an active ingredient in a therapeutically effective amount, or the pharmaceutical composition of claim 7 .

12. A kit comprising a compound of claim 1 as an active ingredient in a therapeutically effective amount, and an instruction for use in the treatment of neurological diseases and associated complications wherein the associated complications are selected from the group consisting of depression, treatment resistant depression, chronic pain and combinations thereof.

13. A kit comprising a pharmaceutical composition of claim 7 , and an instruction for use in the treatment of neurological diseases and associated complications wherein the associated complications are selected from the group consisting of depression, treatment resistant depression, chronic pain and combinations thereof.

14. The pharmaceutical compositions of claim 10 , wherein said pharmaceutical compositions are formulated for the treatment of a neurological diseases or an associated complication wherein the associated complication is selected from the group consisting of depression, treatment resistant depression, chronic pain and combinations thereof.

15. A pharmaceutical composition comprising a compound of claim 2 as an active ingredient in a therapeutically effective amount; and a pharmaceutically acceptable excipient and/or pharmaceutically acceptable carrier.

16. The pharmaceutical composition of claim 15 , wherein the pharmaceutically acceptable excipient is selected from the group comprising of a stabilizer, an inert carrier, a vehicle, a diluent, a surfactant, a filler, a humectant, an adsorbent, an antiadherent, a binder, a lubricant, a glidant, a super disintegrant, a disintegrant, a preservative, an antioxidant, a solution retarding agent, an absorption accelerator, a wetting agent, an absorbent, a coloring agent, a flavoring agent, a sorbent, a coating agent, a sweetener, a buffering agent, a propellant, and mixtures thereof.

17. The pharmaceutical composition of claim 15 , wherein the pharmaceutical composition is formulated as an oral dosage form, systemic dosage form, topical dosage form, spray, parenteral dosage form, subdermal dosage form, or transdermal dosage form.

18. The pharmaceutical composition of claim 15 , wherein the pharmaceutical composition is formulated in a unit dosage form selected from the group consisting of tablet, sublingual tablet, mucoadhesive tablet, multilayer tablet, capsule, capsules containing tablet, controlled-release form, sustained-release form, suppository, tampons, pessaries, pill, lozenge, powder, beads, granule, nanoparticles, beads or granules in solid or liquid forms, oral spray, nasal spray, mucoadhesive spray, intra nasal spray, foam, nasal inhaler, liquid solution, syrups, elixirs, emulsions, microemulsions, subdermal autoinjector, intramuscular autoinjector, injection, stereotactic injection, liquid suspension, intravenous suspension, sterile parenteral solution, sterile parenteral suspension, sterile non-parenteral solution, sterile non-parenteral suspension, topical ointment, topical paste, topical cream, topical lotion, topical gel, and transdermal patch.

19. A method of the treatment or amelioration of neurological diseases or an associated complication, wherein the associated complication is selected from the group consisting of depression, treatment resistant depression, chronic pain and combinations thereof, and comprising administering to a patient suffering from neurological diseases or associated complications the compound of claim 2 as an active ingredient in a therapeutically effective amount, or the pharmaceutical composition of claim 15 .

20. A kit comprising a compound of claim 2 as an active ingredient in a therapeutically effective amount, and an instruction for use in the treatment of neurological diseases and associated complications wherein the associated complications are selected from the group consisting of depression, treatment resistant depression, chronic pain and combinations thereof.

21. The pharmaceutical compositions of claim 18 , wherein said pharmaceutical compositions are formulated for the treatment of neurological diseases or an associated complication wherein the associated complication is selected from the group consisting of depression, treatment resistant depression, chronic pain and combinations thereof.